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Design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / Sharipah Razali

Multi-particulate Dome matrix with sustained-release melatonin and delayed-release caffeine was designed to restore jet lag sleep-wake cycle. The polymeric pellets were produced using extrusion-spheronization technique and fluid-bed coated when applicable. The compact and Dome module were produced b...

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Main Author: Razali, Sharipah
Format: Thesis
Language:English
Published: 2022
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Online Access:https://ir.uitm.edu.my/id/eprint/76547/1/76547.pdf
https://ir.uitm.edu.my/id/eprint/76547/
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spelling my.uitm.ir.765472023-05-29T03:25:35Z https://ir.uitm.edu.my/id/eprint/76547/ Design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / Sharipah Razali Razali, Sharipah Indexes (General) Multi-particulate Dome matrix with sustained-release melatonin and delayed-release caffeine was designed to restore jet lag sleep-wake cycle. The polymeric pellets were produced using extrusion-spheronization technique and fluid-bed coated when applicable. The compact and Dome module were produced by compressing pellets with cushioning agent unless otherwise stated. Dome matrix was assembly of modules with pre-determined compact formulation and drug release characteristics. Melatonin loaded alginate/chitosan-less matrix exhibited almost 100% melatonin release within 8 h gastrointestinal transit with low viscosity hydroxypropyl methylcellulose as cushioning agent. Delayed-release alginate-chitosan caffeine matrix was not attainable through polymer coating due to the premature coat detachment. Admixing of cushioning agent high viscosity hydroxypropyl methylcellulose and high viscosity ethyl cellulose (9:1 weight ratio) with coat-free caffeine loaded particulates introduced delayed-release response via hydroxypropyl methylcellulose swelled in early dissolution phase and ethyl cellulose sustained matrix hydrophobicity at prolonged phase. The caffeine was release substantially in colonic fluid in response to matrix polymers being degraded by rat colonic content. Dome matrix with gastric- specific sustained-release melatonin and intestinal-specific delayed-release caffeine was introduced as an alternative design to introduce melatonin-induced sleep phase then caffeine-stimulated wake phase in restoration of jet lag sleep-wake cycle. To enable efficient gastric and intestinal targeting, intermediate dispersible modules were introduced to detach the melatonin module from the caffeine module along the gastrointestinal transit. The Dome matrix was an assembly of caffeine module with melatonin modules capped at both ends via intermediate dispersible modules (75:25 weight ratio of crospovidone and low viscosity hydroxypropyl methylcellulose). Dome matrix was designed with melatonin module in void configuration and caffeine module in pile configuration to enable the melatonin module to float in the gastric cavity and caffeine module to transit downwards into the intestinal tract. Through using intermediate dispersible module, the melatonin module was detachable from the Dome matrix without incurring surface damages to the caffeine module. The detachment of melatonin module with minimal caffeine module damage further prolonged the caffeine release, with majority of caffeine being delivered in the colonic region (> 85 %). Dome matrix with dual drug release kinetics and targeting sites was produced to introduce melatonin-induced sleep phase then caffeine- stimulated wake phase 2022 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/76547/1/76547.pdf Design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / Sharipah Razali. (2022) PhD thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/76547.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Indexes (General)
spellingShingle Indexes (General)
Razali, Sharipah
Design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / Sharipah Razali
description Multi-particulate Dome matrix with sustained-release melatonin and delayed-release caffeine was designed to restore jet lag sleep-wake cycle. The polymeric pellets were produced using extrusion-spheronization technique and fluid-bed coated when applicable. The compact and Dome module were produced by compressing pellets with cushioning agent unless otherwise stated. Dome matrix was assembly of modules with pre-determined compact formulation and drug release characteristics. Melatonin loaded alginate/chitosan-less matrix exhibited almost 100% melatonin release within 8 h gastrointestinal transit with low viscosity hydroxypropyl methylcellulose as cushioning agent. Delayed-release alginate-chitosan caffeine matrix was not attainable through polymer coating due to the premature coat detachment. Admixing of cushioning agent high viscosity hydroxypropyl methylcellulose and high viscosity ethyl cellulose (9:1 weight ratio) with coat-free caffeine loaded particulates introduced delayed-release response via hydroxypropyl methylcellulose swelled in early dissolution phase and ethyl cellulose sustained matrix hydrophobicity at prolonged phase. The caffeine was release substantially in colonic fluid in response to matrix polymers being degraded by rat colonic content. Dome matrix with gastric- specific sustained-release melatonin and intestinal-specific delayed-release caffeine was introduced as an alternative design to introduce melatonin-induced sleep phase then caffeine-stimulated wake phase in restoration of jet lag sleep-wake cycle. To enable efficient gastric and intestinal targeting, intermediate dispersible modules were introduced to detach the melatonin module from the caffeine module along the gastrointestinal transit. The Dome matrix was an assembly of caffeine module with melatonin modules capped at both ends via intermediate dispersible modules (75:25 weight ratio of crospovidone and low viscosity hydroxypropyl methylcellulose). Dome matrix was designed with melatonin module in void configuration and caffeine module in pile configuration to enable the melatonin module to float in the gastric cavity and caffeine module to transit downwards into the intestinal tract. Through using intermediate dispersible module, the melatonin module was detachable from the Dome matrix without incurring surface damages to the caffeine module. The detachment of melatonin module with minimal caffeine module damage further prolonged the caffeine release, with majority of caffeine being delivered in the colonic region (> 85 %). Dome matrix with dual drug release kinetics and targeting sites was produced to introduce melatonin-induced sleep phase then caffeine- stimulated wake phase
format Thesis
author Razali, Sharipah
author_facet Razali, Sharipah
author_sort Razali, Sharipah
title Design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / Sharipah Razali
title_short Design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / Sharipah Razali
title_full Design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / Sharipah Razali
title_fullStr Design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / Sharipah Razali
title_full_unstemmed Design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / Sharipah Razali
title_sort design of multi-particulate compact and “dome matrix” with sustained-release melatonin and delayed- release caffeine for jet lag treatment / sharipah razali
publishDate 2022
url https://ir.uitm.edu.my/id/eprint/76547/1/76547.pdf
https://ir.uitm.edu.my/id/eprint/76547/
_version_ 1768011585380417536
score 13.211869

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