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Development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on PCNE system V9.1 / Nurulfalahin Daud @ Ibrahim

Background: Radiopharmaceuticals are radioactive drugs utilized for both diagnostic and therapeutic purposes. The significant benefits of radiopharmaceuticals to patient management have been recognized and the usage is expected to increase in the future. In order to optimize the desired outcome bene...

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Main Author: Daud @ Ibrahim, Nurulfalahin
Format: Thesis
Language:English
Published: 2022
Subjects:
Pharmaceutical technology
Online Access:https://ir.uitm.edu.my/id/eprint/72665/2/72665.pdf
https://ir.uitm.edu.my/id/eprint/72665/
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spelling my.uitm.ir.726652023-02-01T09:03:55Z https://ir.uitm.edu.my/id/eprint/72665/ Development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on PCNE system V9.1 / Nurulfalahin Daud @ Ibrahim Daud @ Ibrahim, Nurulfalahin Pharmaceutical technology Background: Radiopharmaceuticals are radioactive drugs utilized for both diagnostic and therapeutic purposes. The significant benefits of radiopharmaceuticals to patient management have been recognized and the usage is expected to increase in the future. In order to optimize the desired outcome benefit in patients receiving radiopharmaceuticals, drug related problems (DRP) associated with them should be identified and managed accordingly. However, the data on DRP in this group of patients are still limited. A classification system for drug related problem is necessary to allow the identification and documentation of drug related problem in a systematic way. The lack of requirements for unique properties of radiopharmaceuticals in currently available classification systems could make the identification of DRP to be difficult. Objective: This study is aimed to identify the types of drug related problem associated with radiopharmaceuticals and develop a preliminary classification system for drug related problem in patients receiving radiopharmaceuticals. Methods: The DRPr are identified through a systematic literature search according to PRISMA guidelines. Electronic databases (Medline and Web of Science) and Google search are conducted to identify the DRPr. By analysing the identified DRPr, a preliminary classification system is developed from adaptation of Pharmaceutical Care Network Europe (PCNE) System for DRP V9.1. Results: The results of this study show 62 types of DRP in patients receiving radiopharmaceuticals identified in the literature which includes imaging problems, altered biodistribution, adverse drug reactions, drug-radiopharmaceutical and food radiopharmaceutical interaction, drug selection problems, dosimetry problems, and administration problems. A preliminary classification system is developed with addition of several categories and subcategories that are missing in the PCNE System V9.1 to fit with the classification of DRPr. The items for category of the preliminary classification system includes treatment effectiveness, treatment safety, imaging problems, altered biodistribution, drug selection, dose selection, preparation and formulation, drug use process, patient related, dosimetry and other. Conclusions: The identified DRPr in the literature would potentially serve as a new insight for healthcare professionals regarding the occurrence of DRPr. Healthcare professionals should report and properly document any DRPr that occurs in nuclear medicine department. The developed preliminary classification system can be utilized to identify DRPr in nuclear medicine and facilitate its development for further refinement in future research. 2022 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/72665/2/72665.pdf Development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on PCNE system V9.1 / Nurulfalahin Daud @ Ibrahim. (2022) Masters thesis, thesis, Universiti Teknologi MARA (UiTM).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical technology
spellingShingle Pharmaceutical technology
Daud @ Ibrahim, Nurulfalahin
Development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on PCNE system V9.1 / Nurulfalahin Daud @ Ibrahim
description Background: Radiopharmaceuticals are radioactive drugs utilized for both diagnostic and therapeutic purposes. The significant benefits of radiopharmaceuticals to patient management have been recognized and the usage is expected to increase in the future. In order to optimize the desired outcome benefit in patients receiving radiopharmaceuticals, drug related problems (DRP) associated with them should be identified and managed accordingly. However, the data on DRP in this group of patients are still limited. A classification system for drug related problem is necessary to allow the identification and documentation of drug related problem in a systematic way. The lack of requirements for unique properties of radiopharmaceuticals in currently available classification systems could make the identification of DRP to be difficult. Objective: This study is aimed to identify the types of drug related problem associated with radiopharmaceuticals and develop a preliminary classification system for drug related problem in patients receiving radiopharmaceuticals. Methods: The DRPr are identified through a systematic literature search according to PRISMA guidelines. Electronic databases (Medline and Web of Science) and Google search are conducted to identify the DRPr. By analysing the identified DRPr, a preliminary classification system is developed from adaptation of Pharmaceutical Care Network Europe (PCNE) System for DRP V9.1. Results: The results of this study show 62 types of DRP in patients receiving radiopharmaceuticals identified in the literature which includes imaging problems, altered biodistribution, adverse drug reactions, drug-radiopharmaceutical and food radiopharmaceutical interaction, drug selection problems, dosimetry problems, and administration problems. A preliminary classification system is developed with addition of several categories and subcategories that are missing in the PCNE System V9.1 to fit with the classification of DRPr. The items for category of the preliminary classification system includes treatment effectiveness, treatment safety, imaging problems, altered biodistribution, drug selection, dose selection, preparation and formulation, drug use process, patient related, dosimetry and other. Conclusions: The identified DRPr in the literature would potentially serve as a new insight for healthcare professionals regarding the occurrence of DRPr. Healthcare professionals should report and properly document any DRPr that occurs in nuclear medicine department. The developed preliminary classification system can be utilized to identify DRPr in nuclear medicine and facilitate its development for further refinement in future research.
format Thesis
author Daud @ Ibrahim, Nurulfalahin
author_facet Daud @ Ibrahim, Nurulfalahin
author_sort Daud @ Ibrahim, Nurulfalahin
title Development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on PCNE system V9.1 / Nurulfalahin Daud @ Ibrahim
title_short Development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on PCNE system V9.1 / Nurulfalahin Daud @ Ibrahim
title_full Development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on PCNE system V9.1 / Nurulfalahin Daud @ Ibrahim
title_fullStr Development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on PCNE system V9.1 / Nurulfalahin Daud @ Ibrahim
title_full_unstemmed Development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on PCNE system V9.1 / Nurulfalahin Daud @ Ibrahim
title_sort development of preliminary classification system for drug related problem in patients receiving radio pharmaceuticals based on pcne system v9.1 / nurulfalahin daud @ ibrahim
publishDate 2022
url https://ir.uitm.edu.my/id/eprint/72665/2/72665.pdf
https://ir.uitm.edu.my/id/eprint/72665/
_version_ 1758581695614812160
score 13.222552

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