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Evaluation of the VKORC1 haplotypes in individualising warfarin therapy / Mohd Zaki Salleh, Teh Lay Kek and Fazleen Haslinda Mohd Hatta

Coumarin derivatives such as warfarin are the therapy of choice for the long-term treatment and prevention of thromboembolic events. Warfarin is administered orally as a racemic mixture of two enantiomers. It has very narrow therapeutic windows and large individual variability. The amount of dose ne...

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Main Authors: Salleh, Mohd Zaki, Teh, Lay Kek, Mohd Hatta, Fazleen Haslinda
Format: Research Reports
Language:English
Published: 2010
Online Access:https://ir.uitm.edu.my/id/eprint/72623/1/72623.pdf
https://ir.uitm.edu.my/id/eprint/72623/
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spelling my.uitm.ir.726232024-06-19T04:48:40Z https://ir.uitm.edu.my/id/eprint/72623/ Evaluation of the VKORC1 haplotypes in individualising warfarin therapy / Mohd Zaki Salleh, Teh Lay Kek and Fazleen Haslinda Mohd Hatta Salleh, Mohd Zaki Teh, Lay Kek Mohd Hatta, Fazleen Haslinda Coumarin derivatives such as warfarin are the therapy of choice for the long-term treatment and prevention of thromboembolic events. Warfarin is administered orally as a racemic mixture of two enantiomers. It has very narrow therapeutic windows and large individual variability. The amount of dose needed to achieve therapeutic efficacy varies across the population due to differences in the genetic makeup of individual patients. Polymorphism of the VKORCl gene is one of the genetic factors that caused altered sensitivity to warfarin or warfarin resistance. Ten common SNPs have been identified, at positions 381, 861, 2653, 3673, 5808, 6009, 6484, 6853, 7566, and 9041 of the VKORCl reference sequence (Gen Bank accession number AY587020). Five major haplotypes were derived and haplotypes HI and H2 were assigned to group A which requires low warfarin dose while haplotypes H7, H8 and H9 were assigned to group B and require high-warfarin dose. Objective: To develop genotyping method for detection often variants of VKORCl gene and establish the distribution of VKORCl haplotypes among patients prescribed with warfarin and study the relationship of haplotypes and warfarin dose, INR and bleeding. 2010 Research Reports NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/72623/1/72623.pdf Evaluation of the VKORC1 haplotypes in individualising warfarin therapy / Mohd Zaki Salleh, Teh Lay Kek and Fazleen Haslinda Mohd Hatta. (2010) [Research Reports] (Unpublished)
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
description Coumarin derivatives such as warfarin are the therapy of choice for the long-term treatment and prevention of thromboembolic events. Warfarin is administered orally as a racemic mixture of two enantiomers. It has very narrow therapeutic windows and large individual variability. The amount of dose needed to achieve therapeutic efficacy varies across the population due to differences in the genetic makeup of individual patients. Polymorphism of the VKORCl gene is one of the genetic factors that caused altered sensitivity to warfarin or warfarin resistance. Ten common SNPs have been identified, at positions 381, 861, 2653, 3673, 5808, 6009, 6484, 6853, 7566, and 9041 of the VKORCl reference sequence (Gen Bank accession number AY587020). Five major haplotypes were derived and haplotypes HI and H2 were assigned to group A which requires low warfarin dose while haplotypes H7, H8 and H9 were assigned to group B and require high-warfarin dose. Objective: To develop genotyping method for detection often variants of VKORCl gene and establish the distribution of VKORCl haplotypes among patients prescribed with warfarin and study the relationship of haplotypes and warfarin dose, INR and bleeding.
format Research Reports
author Salleh, Mohd Zaki
Teh, Lay Kek
Mohd Hatta, Fazleen Haslinda
spellingShingle Salleh, Mohd Zaki
Teh, Lay Kek
Mohd Hatta, Fazleen Haslinda
Evaluation of the VKORC1 haplotypes in individualising warfarin therapy / Mohd Zaki Salleh, Teh Lay Kek and Fazleen Haslinda Mohd Hatta
author_facet Salleh, Mohd Zaki
Teh, Lay Kek
Mohd Hatta, Fazleen Haslinda
author_sort Salleh, Mohd Zaki
title Evaluation of the VKORC1 haplotypes in individualising warfarin therapy / Mohd Zaki Salleh, Teh Lay Kek and Fazleen Haslinda Mohd Hatta
title_short Evaluation of the VKORC1 haplotypes in individualising warfarin therapy / Mohd Zaki Salleh, Teh Lay Kek and Fazleen Haslinda Mohd Hatta
title_full Evaluation of the VKORC1 haplotypes in individualising warfarin therapy / Mohd Zaki Salleh, Teh Lay Kek and Fazleen Haslinda Mohd Hatta
title_fullStr Evaluation of the VKORC1 haplotypes in individualising warfarin therapy / Mohd Zaki Salleh, Teh Lay Kek and Fazleen Haslinda Mohd Hatta
title_full_unstemmed Evaluation of the VKORC1 haplotypes in individualising warfarin therapy / Mohd Zaki Salleh, Teh Lay Kek and Fazleen Haslinda Mohd Hatta
title_sort evaluation of the vkorc1 haplotypes in individualising warfarin therapy / mohd zaki salleh, teh lay kek and fazleen haslinda mohd hatta
publishDate 2010
url https://ir.uitm.edu.my/id/eprint/72623/1/72623.pdf
https://ir.uitm.edu.my/id/eprint/72623/
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score 13.211869

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