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Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali

Glaucoma is the major cause of an irreversible blindness worldwide and it is commonly associated with an elevation of intraocular pressure. ACE inhibitors have been shown to have ocular hypotensive effect in animals and human subjects. The aim of the study was to evaluate the ocular hypotensive effe...

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Main Author: Zaukafali, Tajul Atiqah
Format: Thesis
Language:English
Published: 2013
Subjects:
QP Physiology
Particular diseases of the eye
Online Access:https://ir.uitm.edu.my/id/eprint/72215/1/72215.pdf
https://ir.uitm.edu.my/id/eprint/72215/
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spelling my.uitm.ir.722152024-01-05T03:49:19Z https://ir.uitm.edu.my/id/eprint/72215/ Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali Zaukafali, Tajul Atiqah QP Physiology Particular diseases of the eye Glaucoma is the major cause of an irreversible blindness worldwide and it is commonly associated with an elevation of intraocular pressure. ACE inhibitors have been shown to have ocular hypotensive effect in animals and human subjects. The aim of the study was to evaluate the ocular hypotensive effect and the effect on attenuation of trabecular meshwork remodelling by topical application of ACE inhibitor, enalaprilat dehydrate in chronic steroid-induced ocular hypertensive rat model. Ocular hypertension was developed in normotensive Sprague Dawley rats (100-120g) of either sex by topical instillation of dexamethasone 0.1%, 2 times daily for 36 days. The rats that developed more than 25% rise in IOP were considered ocular hypertensive. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/72215/1/72215.pdf Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali. (2013) Degree thesis, thesis, Universiti Teknologi MARA (UiTM).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic QP Physiology
Particular diseases of the eye
spellingShingle QP Physiology
Particular diseases of the eye
Zaukafali, Tajul Atiqah
Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali
description Glaucoma is the major cause of an irreversible blindness worldwide and it is commonly associated with an elevation of intraocular pressure. ACE inhibitors have been shown to have ocular hypotensive effect in animals and human subjects. The aim of the study was to evaluate the ocular hypotensive effect and the effect on attenuation of trabecular meshwork remodelling by topical application of ACE inhibitor, enalaprilat dehydrate in chronic steroid-induced ocular hypertensive rat model. Ocular hypertension was developed in normotensive Sprague Dawley rats (100-120g) of either sex by topical instillation of dexamethasone 0.1%, 2 times daily for 36 days. The rats that developed more than 25% rise in IOP were considered ocular hypertensive.
format Thesis
author Zaukafali, Tajul Atiqah
author_facet Zaukafali, Tajul Atiqah
author_sort Zaukafali, Tajul Atiqah
title Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali
title_short Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali
title_full Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali
title_fullStr Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali
title_full_unstemmed Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali
title_sort role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / tajul atiqah zaulkafali
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/72215/1/72215.pdf
https://ir.uitm.edu.my/id/eprint/72215/
_version_ 1787525199483109376
score 13.211869

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