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Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah

The study investigated the aerosolization and inhalation profiles of rifampicin-oleic acid first generation liquid and solid nanoemulsions and their respective chitosan- and chitosan-folate conjugate-decorated second and third generation nanoemulsions. The liquid nanoemulsions were prepared by spont...

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Main Author: Shah, Kifayat Ullah
Format: Thesis
Language:English
Published: 2017
Subjects:
Antibiotic therapy. Antibiotics
TJ Mechanical engineering and machinery
Online Access:https://ir.uitm.edu.my/id/eprint/70900/1/70900.pdf
https://ir.uitm.edu.my/id/eprint/70900/
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spelling my.uitm.ir.709002024-02-27T02:41:39Z https://ir.uitm.edu.my/id/eprint/70900/ Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah Shah, Kifayat Ullah Antibiotic therapy. Antibiotics TJ Mechanical engineering and machinery The study investigated the aerosolization and inhalation profiles of rifampicin-oleic acid first generation liquid and solid nanoemulsions and their respective chitosan- and chitosan-folate conjugate-decorated second and third generation nanoemulsions. The liquid nanoemulsions were prepared by spontaneous emulsification method and had their size, zeta potential, polydispersity index, morphology, pH, viscosity, surface tension, density, refractive index, drug content, drug release, aerosolization and inhalation profiles characterized. The first, second and third generation nanoemulsions had average droplet sizes of 43.89 ± 0.36 nm, 52.12 ± 0.36 nm and 59.69 ± 0.26 nm, with narrow polydispersity indices at 0.16 ± 0.03, 0.25 ± 0.03 and 0.23 ± 0.01 respectively. They exhibited desirable pH, surface tension, viscosity, refractive index, density, and viscosity attributes for pulmonary rifampicin administration. The second generation nanoemulsion was characterized by relatively low levels of burst drug release due to intimate chitosan packing at the oil globules’ surfaces and viscosifying effect on continuous phase, which was unattainable by the branched folate conjugate of chitosan. All nanoemulsions demonstrated more than 95 % aerosol output and inhalation efficiency greater than 75 % when delivered by nebulization. The aerosol output, aerosolized and inhaled fine particle fractions were primarily governed by the size and surface tension of nanoemulsions in an inverse relationship. The first, second and third generation nanoemulsions were converted to their corresponding solid counterparts by spray drying method. 2017 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/70900/1/70900.pdf Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah. (2017) PhD thesis, thesis, Universiti Teknologi MARA (UiTM).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Antibiotic therapy. Antibiotics
TJ Mechanical engineering and machinery
spellingShingle Antibiotic therapy. Antibiotics
TJ Mechanical engineering and machinery
Shah, Kifayat Ullah
Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
description The study investigated the aerosolization and inhalation profiles of rifampicin-oleic acid first generation liquid and solid nanoemulsions and their respective chitosan- and chitosan-folate conjugate-decorated second and third generation nanoemulsions. The liquid nanoemulsions were prepared by spontaneous emulsification method and had their size, zeta potential, polydispersity index, morphology, pH, viscosity, surface tension, density, refractive index, drug content, drug release, aerosolization and inhalation profiles characterized. The first, second and third generation nanoemulsions had average droplet sizes of 43.89 ± 0.36 nm, 52.12 ± 0.36 nm and 59.69 ± 0.26 nm, with narrow polydispersity indices at 0.16 ± 0.03, 0.25 ± 0.03 and 0.23 ± 0.01 respectively. They exhibited desirable pH, surface tension, viscosity, refractive index, density, and viscosity attributes for pulmonary rifampicin administration. The second generation nanoemulsion was characterized by relatively low levels of burst drug release due to intimate chitosan packing at the oil globules’ surfaces and viscosifying effect on continuous phase, which was unattainable by the branched folate conjugate of chitosan. All nanoemulsions demonstrated more than 95 % aerosol output and inhalation efficiency greater than 75 % when delivered by nebulization. The aerosol output, aerosolized and inhaled fine particle fractions were primarily governed by the size and surface tension of nanoemulsions in an inverse relationship. The first, second and third generation nanoemulsions were converted to their corresponding solid counterparts by spray drying method.
format Thesis
author Shah, Kifayat Ullah
author_facet Shah, Kifayat Ullah
author_sort Shah, Kifayat Ullah
title Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_short Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_full Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_fullStr Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_full_unstemmed Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_sort liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / kifayat ullah shah
publishDate 2017
url https://ir.uitm.edu.my/id/eprint/70900/1/70900.pdf
https://ir.uitm.edu.my/id/eprint/70900/
_version_ 1792159342008467456
score 13.211869

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