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Relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / Goh Siew Wen ... [et al.]

Introduction: The atopic march consists of atopic dermatitis (AD), allergic rhinitis or sinusitis (AR), allergic conjunctivitis (AC) and bronchial asthma (BA). The influence of concomitant atopic diseases on AD is under-explored. We determined the relationship between personal and family history of...

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Main Authors: Goh, Siew Wen, Jamil, Adawiyah, Lee, Choon Sian, Arumugam, Mohan
Format: Article
Language:English
Published: Faculty of Medicine 2021
Subjects:
Diseases associated with hypersensitivity. Allergic diseases of the skin
Eczema
Online Access:https://ir.uitm.edu.my/id/eprint/70460/1/70460.pdf
https://ir.uitm.edu.my/id/eprint/70460/
https://doi.org/10.24191/jchs.v6i2.9507
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spelling my.uitm.ir.704602022-11-21T04:30:57Z https://ir.uitm.edu.my/id/eprint/70460/ Relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / Goh Siew Wen ... [et al.] Goh, Siew Wen Jamil, Adawiyah Lee, Choon Sian Arumugam, Mohan Diseases associated with hypersensitivity. Allergic diseases of the skin Eczema Introduction: The atopic march consists of atopic dermatitis (AD), allergic rhinitis or sinusitis (AR), allergic conjunctivitis (AC) and bronchial asthma (BA). The influence of concomitant atopic diseases on AD is under-explored. We determined the relationship between personal and family history of atopic diseases with AD severity and persistence. Methods: A cross sectional study involving AD patients was performed at dermatology clinics of two tertiary hospitals. Inclusion criterion was all patients diagnosed with AD. Demographic data, personal and family history of atopy (BA, AR and AC) were obtained by face-to-face interview. AD severity was evaluated using Investigator’s Global Assessment (IGA). AD was considered persistent if continued beyond age 12 years. Results: Sixty patients aged 21.6±17.2 participated. There were 25(41.7%) with concomitant AR, 16(26.7%) BA and 12(20%) AC. Forty seven (78.3%) patients had family history of atopy, 25(41.7%) had eczema, 24(40%) AR, 19(31.7%) BA and 2(3.3%) AC. Patients with BA [OR=3.8, 95%CI 1.04 to 14.4)], BA and AR [OR=9.74, 95%CI 1.13 to 83.67) and family history of BA [OR= 4.00, 95%CI 1.20 to 13.27) were more likely to exhibit moderate-severe AD. Personal AR, AC and family history of AD and BA were significantly more prevalent in patients with persistent AD. Conclusions: AR was the most common atopic disease associated with AD. Family history of eczema and AR were common. Personal BA, BA with AR and family history of BA were predictors of severe AD. Personal AR, AC and family history of AD and BA were associated with AD persistence. Faculty of Medicine 2021-09 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/70460/1/70460.pdf Relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / Goh Siew Wen ... [et al.]. (2021) Journal of Clinical and Health Sciences (JCHS), 6 (2). pp. 43-47. ISSN 0127-984X https://doi.org/10.24191/jchs.v6i2.9507
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Diseases associated with hypersensitivity. Allergic diseases of the skin
Eczema
spellingShingle Diseases associated with hypersensitivity. Allergic diseases of the skin
Eczema
Goh, Siew Wen
Jamil, Adawiyah
Lee, Choon Sian
Arumugam, Mohan
Relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / Goh Siew Wen ... [et al.]
description Introduction: The atopic march consists of atopic dermatitis (AD), allergic rhinitis or sinusitis (AR), allergic conjunctivitis (AC) and bronchial asthma (BA). The influence of concomitant atopic diseases on AD is under-explored. We determined the relationship between personal and family history of atopic diseases with AD severity and persistence. Methods: A cross sectional study involving AD patients was performed at dermatology clinics of two tertiary hospitals. Inclusion criterion was all patients diagnosed with AD. Demographic data, personal and family history of atopy (BA, AR and AC) were obtained by face-to-face interview. AD severity was evaluated using Investigator’s Global Assessment (IGA). AD was considered persistent if continued beyond age 12 years. Results: Sixty patients aged 21.6±17.2 participated. There were 25(41.7%) with concomitant AR, 16(26.7%) BA and 12(20%) AC. Forty seven (78.3%) patients had family history of atopy, 25(41.7%) had eczema, 24(40%) AR, 19(31.7%) BA and 2(3.3%) AC. Patients with BA [OR=3.8, 95%CI 1.04 to 14.4)], BA and AR [OR=9.74, 95%CI 1.13 to 83.67) and family history of BA [OR= 4.00, 95%CI 1.20 to 13.27) were more likely to exhibit moderate-severe AD. Personal AR, AC and family history of AD and BA were significantly more prevalent in patients with persistent AD. Conclusions: AR was the most common atopic disease associated with AD. Family history of eczema and AR were common. Personal BA, BA with AR and family history of BA were predictors of severe AD. Personal AR, AC and family history of AD and BA were associated with AD persistence.
format Article
author Goh, Siew Wen
Jamil, Adawiyah
Lee, Choon Sian
Arumugam, Mohan
author_facet Goh, Siew Wen
Jamil, Adawiyah
Lee, Choon Sian
Arumugam, Mohan
author_sort Goh, Siew Wen
title Relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / Goh Siew Wen ... [et al.]
title_short Relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / Goh Siew Wen ... [et al.]
title_full Relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / Goh Siew Wen ... [et al.]
title_fullStr Relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / Goh Siew Wen ... [et al.]
title_full_unstemmed Relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / Goh Siew Wen ... [et al.]
title_sort relationship between concomitant atopic diseases with atopic dermatitis severity and persistence / goh siew wen ... [et al.]
publisher Faculty of Medicine
publishDate 2021
url https://ir.uitm.edu.my/id/eprint/70460/1/70460.pdf
https://ir.uitm.edu.my/id/eprint/70460/
https://doi.org/10.24191/jchs.v6i2.9507
_version_ 1751540020092600320
score 13.211869

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