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Formulation & evaluation of Myrrh toothpaste / Abd Majid N.H ... [et al.]

Objectives: To formulate and measure the cytotoxicity level of organic myrrh toothpaste. Materials and Methods: Myrrh extract was prepared by the freeze drying process. Toothpaste was formulated by mixing specified amounts of myrrh extract, hydroxypropyl methylcellulose (HPMC) polymer, sodium lauryl...

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Main Authors: Abd Majid, N.H., Abdul Rahim, R.S, Younis, L.T, Abu Hassan, M.I
Format: Article
Language:English
Published: Faculty of Dentistry, Universiti Teknologi MARA 2022
Subjects:
Preventive dentistry
Dental health education
Online Access:https://ir.uitm.edu.my/id/eprint/69887/1/69887.pdf
https://ir.uitm.edu.my/id/eprint/69887/
https://doi.org/10.24191/cos.v9i2.19227
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spelling my.uitm.ir.698872022-11-16T01:48:43Z https://ir.uitm.edu.my/id/eprint/69887/ Formulation & evaluation of Myrrh toothpaste / Abd Majid N.H ... [et al.] Abd Majid, N.H. Abdul Rahim, R.S Younis, L.T Abu Hassan, M.I Preventive dentistry Dental health education Objectives: To formulate and measure the cytotoxicity level of organic myrrh toothpaste. Materials and Methods: Myrrh extract was prepared by the freeze drying process. Toothpaste was formulated by mixing specified amounts of myrrh extract, hydroxypropyl methylcellulose (HPMC) polymer, sodium lauryl sulphate (SLS), mint, and sucralose with deionized distilled water. MTT test was performed using concentrations of 100, 200, 300 and 400 mg/ml to assess the effect of myrrh paste on the gingival fibroblasts viability at intervals of 24 and 48hrs. The results were analysed by using SPSS version 27. Results: The formulated myrrh toothpaste has a homogeneous consistency as the extracted myrrh successfully dissolved completely with the other components. Cell viability test showed that myrrh paste concentrations of 100 - 300mg/ml were effective in maintaining the rate of fibroblasts growth after 24 and 48 hours as compared to the control samples. Cell growth rate was suppressed in the test samples treated with paste concentration of 400mg/ml. The results of the study imply that 300mg/ml is the safe and optimal concentration for fibroblasts growth, whereas concentrations ≥ 400mg/ml are intolerable and might be suppressing the proliferation of fibroblasts. Conclusion: Myrrh toothpaste concentration at 300mg/ml is the safe and optimal concentration for fibroblasts growth as depicted in the results, suggesting that at the optimal formulation, myrrh extract may not be toxic to the soft tissues and myrrh toothpaste may be useful for oral health care. Further clinical investigations are recommended to obtain the clinical efficacy data of the organic myrrh toothpaste. Faculty of Dentistry, Universiti Teknologi MARA 2022 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/69887/1/69887.pdf Formulation & evaluation of Myrrh toothpaste / Abd Majid N.H ... [et al.]. (2022) Compendium of Oral Science (CORALS), 9 (2). pp. 13-22. ISSN 2489-1102; 2637-0611 (Submitted) https://doi.org/10.24191/cos.v9i2.19227
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Preventive dentistry
Dental health education
spellingShingle Preventive dentistry
Dental health education
Abd Majid, N.H.
Abdul Rahim, R.S
Younis, L.T
Abu Hassan, M.I
Formulation & evaluation of Myrrh toothpaste / Abd Majid N.H ... [et al.]
description Objectives: To formulate and measure the cytotoxicity level of organic myrrh toothpaste. Materials and Methods: Myrrh extract was prepared by the freeze drying process. Toothpaste was formulated by mixing specified amounts of myrrh extract, hydroxypropyl methylcellulose (HPMC) polymer, sodium lauryl sulphate (SLS), mint, and sucralose with deionized distilled water. MTT test was performed using concentrations of 100, 200, 300 and 400 mg/ml to assess the effect of myrrh paste on the gingival fibroblasts viability at intervals of 24 and 48hrs. The results were analysed by using SPSS version 27. Results: The formulated myrrh toothpaste has a homogeneous consistency as the extracted myrrh successfully dissolved completely with the other components. Cell viability test showed that myrrh paste concentrations of 100 - 300mg/ml were effective in maintaining the rate of fibroblasts growth after 24 and 48 hours as compared to the control samples. Cell growth rate was suppressed in the test samples treated with paste concentration of 400mg/ml. The results of the study imply that 300mg/ml is the safe and optimal concentration for fibroblasts growth, whereas concentrations ≥ 400mg/ml are intolerable and might be suppressing the proliferation of fibroblasts. Conclusion: Myrrh toothpaste concentration at 300mg/ml is the safe and optimal concentration for fibroblasts growth as depicted in the results, suggesting that at the optimal formulation, myrrh extract may not be toxic to the soft tissues and myrrh toothpaste may be useful for oral health care. Further clinical investigations are recommended to obtain the clinical efficacy data of the organic myrrh toothpaste.
format Article
author Abd Majid, N.H.
Abdul Rahim, R.S
Younis, L.T
Abu Hassan, M.I
author_facet Abd Majid, N.H.
Abdul Rahim, R.S
Younis, L.T
Abu Hassan, M.I
author_sort Abd Majid, N.H.
title Formulation & evaluation of Myrrh toothpaste / Abd Majid N.H ... [et al.]
title_short Formulation & evaluation of Myrrh toothpaste / Abd Majid N.H ... [et al.]
title_full Formulation & evaluation of Myrrh toothpaste / Abd Majid N.H ... [et al.]
title_fullStr Formulation & evaluation of Myrrh toothpaste / Abd Majid N.H ... [et al.]
title_full_unstemmed Formulation & evaluation of Myrrh toothpaste / Abd Majid N.H ... [et al.]
title_sort formulation & evaluation of myrrh toothpaste / abd majid n.h ... [et al.]
publisher Faculty of Dentistry, Universiti Teknologi MARA
publishDate 2022
url https://ir.uitm.edu.my/id/eprint/69887/1/69887.pdf
https://ir.uitm.edu.my/id/eprint/69887/
https://doi.org/10.24191/cos.v9i2.19227
_version_ 1751539976357543936
score 13.211869

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