Cover Image

New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti

Oral administration is the most viable route to deliver drugs and it is also the method which shows the highest patient compliance. Unfortunately some drugs show a low oral bioavalability or they have a short half-life which require taking several doses in one day. The most common oral dosage form i...

Full description

Saved in:
Bibliographic Details
Main Author: Benetti, Camillo
Format: Thesis
Language:English
Published: 2016
Subjects:
Pharmaceutical technology
Online Access:https://ir.uitm.edu.my/id/eprint/67544/1/67544.pdf
https://ir.uitm.edu.my/id/eprint/67544/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.uitm.ir.67544
record_format eprints
spelling my.uitm.ir.675442023-03-06T09:07:07Z https://ir.uitm.edu.my/id/eprint/67544/ New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti Benetti, Camillo Pharmaceutical technology Oral administration is the most viable route to deliver drugs and it is also the method which shows the highest patient compliance. Unfortunately some drugs show a low oral bioavalability or they have a short half-life which require taking several doses in one day. The most common oral dosage form is the polymeric matrix, especially swellable matrices. The swellable matrix is a monolithic system of drug dispersed or dissolved a polymeric bed. It can be manufactured using soluble and swellable polymer which can control the release of the drug due to polymer geiification upon in contact with an aqueous medium. The geiification of the polymer takes place gradually on time together with the disentanglement of the polymeric chains which elicit matrix erosion. A drug cannot diffuse through the dry (glassy) polymer, but only via the gelled (rubbery) polymer[4]. Figure 1 shows erosion, swelling and diffusion fronts that are encountered in a matrix. 2016 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/67544/1/67544.pdf New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti. (2016) PhD thesis, thesis, Universiti Teknologi MARA (UiTM).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical technology
spellingShingle Pharmaceutical technology
Benetti, Camillo
New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti
description Oral administration is the most viable route to deliver drugs and it is also the method which shows the highest patient compliance. Unfortunately some drugs show a low oral bioavalability or they have a short half-life which require taking several doses in one day. The most common oral dosage form is the polymeric matrix, especially swellable matrices. The swellable matrix is a monolithic system of drug dispersed or dissolved a polymeric bed. It can be manufactured using soluble and swellable polymer which can control the release of the drug due to polymer geiification upon in contact with an aqueous medium. The geiification of the polymer takes place gradually on time together with the disentanglement of the polymeric chains which elicit matrix erosion. A drug cannot diffuse through the dry (glassy) polymer, but only via the gelled (rubbery) polymer[4]. Figure 1 shows erosion, swelling and diffusion fronts that are encountered in a matrix.
format Thesis
author Benetti, Camillo
author_facet Benetti, Camillo
author_sort Benetti, Camillo
title New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti
title_short New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti
title_full New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti
title_fullStr New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti
title_full_unstemmed New modules and assembled systems for the controlled release of drugs in combination / Camillo Benetti
title_sort new modules and assembled systems for the controlled release of drugs in combination / camillo benetti
publishDate 2016
url https://ir.uitm.edu.my/id/eprint/67544/1/67544.pdf
https://ir.uitm.edu.my/id/eprint/67544/
_version_ 1759692723439271936
score 13.211869

Similar Items