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Diagnosis of granulomatosis with polyangiitis - is it that difficult? / Nabia Idaam Mustapa Albakari

GPA is a rare disease with reported annual incidence and prevalence is estimated 23.7-156.5 per million and 3.0-14.4 per million, respectively (1). GPA is more common in European populations and slightly more in male with male to female ratio 1.5: 1 (2). It may occur at any age but typically at age...

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Main Author: Mustapa Albakari, Nabia Idaam
Format: Thesis
Language:English
Published: Faculty of Medicine 2018
Subjects:
Vascular System
Heart
Cardiovascular system
Online Access:https://ir.uitm.edu.my/id/eprint/67012/1/67012.pdf
https://ir.uitm.edu.my/id/eprint/67012/
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spelling my.uitm.ir.670122024-08-21T08:37:35Z https://ir.uitm.edu.my/id/eprint/67012/ Diagnosis of granulomatosis with polyangiitis - is it that difficult? / Nabia Idaam Mustapa Albakari Mustapa Albakari, Nabia Idaam Vascular System Heart Cardiovascular system GPA is a rare disease with reported annual incidence and prevalence is estimated 23.7-156.5 per million and 3.0-14.4 per million, respectively (1). GPA is more common in European populations and slightly more in male with male to female ratio 1.5: 1 (2). It may occur at any age but typically at age 35-55 years old. It classically involved upper and lower respiratory tract and glomerulonephritis. According to American College of Rheumatology (ACR) classification the diagnosis is made when 2 out of 4 criteria are present, which includes nasal or oral inflammation, abnormal chest radiograph, urinary sediment and granulomatous inflammation on biopsy. This test has a sensitivity of 88.2 percent and specificity of92 percent. Otological manifestation are found in 19 to 61 percent of cases with GP A (3 ). The commonest presentation is otitis media ( 4). It is due to eustachian tube dysfunction caused by nasopharyngeal involvement but commonly misdiagnosed as infection (5). Up to 50 percent of GPA cases presented with hearing loss ( 6). Bakthavachalam et al reported that both sensorineural and conductive hearing loss are common in GP A (7). However, audiogram was not done for our patient to determine the type of hearing loss. Faculty of Medicine 2018-10 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/67012/1/67012.pdf Diagnosis of granulomatosis with polyangiitis - is it that difficult? / Nabia Idaam Mustapa Albakari. (2018) Masters thesis, thesis, Universiti Teknologi MARA.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Vascular System
Heart
Cardiovascular system
spellingShingle Vascular System
Heart
Cardiovascular system
Mustapa Albakari, Nabia Idaam
Diagnosis of granulomatosis with polyangiitis - is it that difficult? / Nabia Idaam Mustapa Albakari
description GPA is a rare disease with reported annual incidence and prevalence is estimated 23.7-156.5 per million and 3.0-14.4 per million, respectively (1). GPA is more common in European populations and slightly more in male with male to female ratio 1.5: 1 (2). It may occur at any age but typically at age 35-55 years old. It classically involved upper and lower respiratory tract and glomerulonephritis. According to American College of Rheumatology (ACR) classification the diagnosis is made when 2 out of 4 criteria are present, which includes nasal or oral inflammation, abnormal chest radiograph, urinary sediment and granulomatous inflammation on biopsy. This test has a sensitivity of 88.2 percent and specificity of92 percent. Otological manifestation are found in 19 to 61 percent of cases with GP A (3 ). The commonest presentation is otitis media ( 4). It is due to eustachian tube dysfunction caused by nasopharyngeal involvement but commonly misdiagnosed as infection (5). Up to 50 percent of GPA cases presented with hearing loss ( 6). Bakthavachalam et al reported that both sensorineural and conductive hearing loss are common in GP A (7). However, audiogram was not done for our patient to determine the type of hearing loss.
format Thesis
author Mustapa Albakari, Nabia Idaam
author_facet Mustapa Albakari, Nabia Idaam
author_sort Mustapa Albakari, Nabia Idaam
title Diagnosis of granulomatosis with polyangiitis - is it that difficult? / Nabia Idaam Mustapa Albakari
title_short Diagnosis of granulomatosis with polyangiitis - is it that difficult? / Nabia Idaam Mustapa Albakari
title_full Diagnosis of granulomatosis with polyangiitis - is it that difficult? / Nabia Idaam Mustapa Albakari
title_fullStr Diagnosis of granulomatosis with polyangiitis - is it that difficult? / Nabia Idaam Mustapa Albakari
title_full_unstemmed Diagnosis of granulomatosis with polyangiitis - is it that difficult? / Nabia Idaam Mustapa Albakari
title_sort diagnosis of granulomatosis with polyangiitis - is it that difficult? / nabia idaam mustapa albakari
publisher Faculty of Medicine
publishDate 2018
url https://ir.uitm.edu.my/id/eprint/67012/1/67012.pdf
https://ir.uitm.edu.my/id/eprint/67012/
_version_ 1808975916586500096
score 13.211869

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