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Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah

More than 50% of currently market drug target are from membrane protein. As consequence, both academia and industry targeting membrane protein to be as subject of intense for drug discovery. In order to discover target from membrane protein effectively, researcher need to predict the membrane protei...

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Main Author: Pindah, Winddy
Format: Thesis
Language:English
Published: 2012
Subjects:
Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Pharmaceutical technology
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/63802/1/63802.pdf
https://ir.uitm.edu.my/id/eprint/63802/
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spelling my.uitm.ir.638022022-07-28T10:44:09Z https://ir.uitm.edu.my/id/eprint/63802/ Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah Pindah, Winddy Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Pharmaceutical technology Pharmaceutical chemistry More than 50% of currently market drug target are from membrane protein. As consequence, both academia and industry targeting membrane protein to be as subject of intense for drug discovery. In order to discover target from membrane protein effectively, researcher need to predict the membrane protein-protein interactions (PPIs). Knowledge of PPIs promising new approach to discover drug by targeting the undruggable fragment based. However, to facilitate this task is not easy as their estimation due to the biophysical properties of membrane protein. There are several study have been done to improve PPIs identification in membrane protein, among the solution is incorporating various biologically meaningful data such as network topological features, protein primary sequences and structures. Thus, the objectives of this study are to design an integrated heterogeneous database of membrane protein from Protein Data Bank (PDB), Protein Topology Graph Library (PTGL) and Universal Protein Resource (Uniprot) and to use data from an integrated heterogeneous database of membrane protein resources for membrane proteinprotein interactions (PPIs) identification. Most of information gathered on this study obtained from interview and review to previous related study. This study aims to contribute to development and improvement of technology or tools to study membrane proteins as the important resource for drug target, in order to improve or develop novel pharmacological drug targets. 2012-07 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/63802/1/63802.pdf Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah. (2012) Masters thesis, thesis, Universiti Teknologi MARA.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Pharmaceutical technology
Pharmaceutical chemistry
spellingShingle Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Pharmaceutical technology
Pharmaceutical chemistry
Pindah, Winddy
Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
description More than 50% of currently market drug target are from membrane protein. As consequence, both academia and industry targeting membrane protein to be as subject of intense for drug discovery. In order to discover target from membrane protein effectively, researcher need to predict the membrane protein-protein interactions (PPIs). Knowledge of PPIs promising new approach to discover drug by targeting the undruggable fragment based. However, to facilitate this task is not easy as their estimation due to the biophysical properties of membrane protein. There are several study have been done to improve PPIs identification in membrane protein, among the solution is incorporating various biologically meaningful data such as network topological features, protein primary sequences and structures. Thus, the objectives of this study are to design an integrated heterogeneous database of membrane protein from Protein Data Bank (PDB), Protein Topology Graph Library (PTGL) and Universal Protein Resource (Uniprot) and to use data from an integrated heterogeneous database of membrane protein resources for membrane proteinprotein interactions (PPIs) identification. Most of information gathered on this study obtained from interview and review to previous related study. This study aims to contribute to development and improvement of technology or tools to study membrane proteins as the important resource for drug target, in order to improve or develop novel pharmacological drug targets.
format Thesis
author Pindah, Winddy
author_facet Pindah, Winddy
author_sort Pindah, Winddy
title Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_short Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_full Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_fullStr Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_full_unstemmed Integrated heterogeneous database of membrane protein for protein-protein interactions (PPIs) identification / Winddy Pindah
title_sort integrated heterogeneous database of membrane protein for protein-protein interactions (ppis) identification / winddy pindah
publishDate 2012
url https://ir.uitm.edu.my/id/eprint/63802/1/63802.pdf
https://ir.uitm.edu.my/id/eprint/63802/
_version_ 1739834112836894720
score 13.211869

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