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Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail

Dental Caries is a chronic disease affecting half of the global population, causing pain and discomfort due to progressive damage to the teeth. Whilst xylitol has been studied for its effect on dental caries prevention, current practices present few limitations for its successful oral delivery, incl...

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主要な著者: Yi Ern, Elizabeth Teng, Xixian, Hee, Ismail, Muhamad Fareez
フォーマット: 論文
言語:English
出版事項: Universiti Teknologi MARA 2022
主題:
Synthetic products
Chemical engineering
オンライン･アクセス:https://ir.uitm.edu.my/id/eprint/58253/1/58253.pdf
https://ir.uitm.edu.my/id/eprint/58253/
https://scilett-fsg.uitm.edu.my/
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spelling my.uitm.ir.582532022-04-13T02:43:48Z https://ir.uitm.edu.my/id/eprint/58253/ Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail Yi Ern, Elizabeth Teng Xixian, Hee Ismail, Muhamad Fareez Synthetic products Chemical engineering Dental Caries is a chronic disease affecting half of the global population, causing pain and discomfort due to progressive damage to the teeth. Whilst xylitol has been studied for its effect on dental caries prevention, current practices present few limitations for its successful oral delivery, including short residence time in the mouth and poor patient compliance. Recently, oral thin films (OTFs) emerged as an alternative to delivering xylitol in the oral cavity. This research aims to develop novel OTFs containing xylitol with extended-release properties (as determined by the disintegration time) and to investigate its effect on a cariogenic bacterial strain, Streptococcus mutans. The minimum inhibitory concentration (MIC) of xylitol was determined. Employing the microdilution broth method, the antibacterial activity of the oral thin films containing xylitol for oral S. mutans was performed with simulated salivary fluid, incubated at 1, 4, and 10 h. The MIC of xylitol was found at 10%. Meanwhile, there was no significant difference in the inhibition of S. mutans (p > 0.05) between the control, OTFs (10 h), and xylitol-OTF (1 h), with the latter, demonstrated only 16.58% inhibition. Interestingly, when compared to xylitol-OTF (1 h), xylitol-OTF showed significant inhibition (p < 0.05) to S. mutans after four h (+53.24 %) and almost a complete inhibition after ten h (-92.58 %). These results suggest that the OTFs demonstrated a gradual release of xylitol and inhibited oral biofilm formation by decreasing the growth of S. mutans in a time-dependent manner. Most importantly, the study indicated the successful development of a novel xylitol-OTF with potential as an oral health biotherapeutic agent. Universiti Teknologi MARA 2022-01 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/58253/1/58253.pdf (2022) Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail. Science Letters (ScL), 16 (1): 13. pp. 124-136. ISSN (eISSN): 2682-8626 https://scilett-fsg.uitm.edu.my/
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Synthetic products
Chemical engineering
spellingShingle Synthetic products
Chemical engineering
Yi Ern, Elizabeth Teng
Xixian, Hee
Ismail, Muhamad Fareez
Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail
description Dental Caries is a chronic disease affecting half of the global population, causing pain and discomfort due to progressive damage to the teeth. Whilst xylitol has been studied for its effect on dental caries prevention, current practices present few limitations for its successful oral delivery, including short residence time in the mouth and poor patient compliance. Recently, oral thin films (OTFs) emerged as an alternative to delivering xylitol in the oral cavity. This research aims to develop novel OTFs containing xylitol with extended-release properties (as determined by the disintegration time) and to investigate its effect on a cariogenic bacterial strain, Streptococcus mutans. The minimum inhibitory concentration (MIC) of xylitol was determined. Employing the microdilution broth method, the antibacterial activity of the oral thin films containing xylitol for oral S. mutans was performed with simulated salivary fluid, incubated at 1, 4, and 10 h. The MIC of xylitol was found at 10%. Meanwhile, there was no significant difference in the inhibition of S. mutans (p > 0.05) between the control, OTFs (10 h), and xylitol-OTF (1 h), with the latter, demonstrated only 16.58% inhibition. Interestingly, when compared to xylitol-OTF (1 h), xylitol-OTF showed significant inhibition (p < 0.05) to S. mutans after four h (+53.24 %) and almost a complete inhibition after ten h (-92.58 %). These results suggest that the OTFs demonstrated a gradual release of xylitol and inhibited oral biofilm formation by decreasing the growth of S. mutans in a time-dependent manner. Most importantly, the study indicated the successful development of a novel xylitol-OTF with potential as an oral health biotherapeutic agent.
format Article
author Yi Ern, Elizabeth Teng
Xixian, Hee
Ismail, Muhamad Fareez
author_facet Yi Ern, Elizabeth Teng
Xixian, Hee
Ismail, Muhamad Fareez
author_sort Yi Ern, Elizabeth Teng
title Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail
title_short Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail
title_full Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail
title_fullStr Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail
title_full_unstemmed Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail
title_sort inhibitory effect of oral thin films (otfs) containing xylitol against streptococcus mutans / elizabeth teng yi ern, hee xixian and muhamad fareez ismail
publisher Universiti Teknologi MARA
publishDate 2022
url https://ir.uitm.edu.my/id/eprint/58253/1/58253.pdf
https://ir.uitm.edu.my/id/eprint/58253/
https://scilett-fsg.uitm.edu.my/
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score 13.250246

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