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Cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / Syed Waqar Hussain Shah, Iram Bibi and Sabat Yousaf

Novel derivatives of cationic surfactant cetyltrimethylammonium bromide (CTAB) possessing anions of ibuprofen and naproxen as hydrophobic counterions were synthesized and characterized using Fourier transform infrared and differential electronic absorption spectroscopy. The self-assembly of each sur...

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Main Authors: Hussain Shah, Syed Waqar, Bibi, Iram, Yousaf, Sabat
Format: Article
Language:English
Published: Universiti Teknologi MARA 2022
Subjects:
Chemical engineering
Biotechnology
Online Access:https://ir.uitm.edu.my/id/eprint/58236/1/58236.pdf
https://ir.uitm.edu.my/id/eprint/58236/
https://scilett-fsg.uitm.edu.my/
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spelling my.uitm.ir.582362022-04-13T03:09:36Z https://ir.uitm.edu.my/id/eprint/58236/ Cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / Syed Waqar Hussain Shah, Iram Bibi and Sabat Yousaf Hussain Shah, Syed Waqar Bibi, Iram Yousaf, Sabat Chemical engineering Biotechnology Novel derivatives of cationic surfactant cetyltrimethylammonium bromide (CTAB) possessing anions of ibuprofen and naproxen as hydrophobic counterions were synthesized and characterized using Fourier transform infrared and differential electronic absorption spectroscopy. The self-assembly of each surfactant was investigated using surface tensiometry. The self-immolative nature of these compounds was analyzed by studying their behaviour in response to a trigger such as medium pH. ADMET-SAR (adsorption, distribution, metabolism, excretion, and toxicity – structure-activity relationship) profiles of synthesized surfactants were generated using admetSAR (v. 1.0). The cetrimonium drugs exhibited better profiles than the corresponding pure drugs, saving the aqueous solubility, which was reduced due to the hydrophobicity of counterions. Universiti Teknologi MARA 2022-01 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/58236/1/58236.pdf (2022) Cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / Syed Waqar Hussain Shah, Iram Bibi and Sabat Yousaf. Science Letters (ScL), 16 (1): 15. pp. 31-45. ISSN (eISSN): 2682-8626 https://scilett-fsg.uitm.edu.my/
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Chemical engineering
Biotechnology
spellingShingle Chemical engineering
Biotechnology
Hussain Shah, Syed Waqar
Bibi, Iram
Yousaf, Sabat
Cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / Syed Waqar Hussain Shah, Iram Bibi and Sabat Yousaf
description Novel derivatives of cationic surfactant cetyltrimethylammonium bromide (CTAB) possessing anions of ibuprofen and naproxen as hydrophobic counterions were synthesized and characterized using Fourier transform infrared and differential electronic absorption spectroscopy. The self-assembly of each surfactant was investigated using surface tensiometry. The self-immolative nature of these compounds was analyzed by studying their behaviour in response to a trigger such as medium pH. ADMET-SAR (adsorption, distribution, metabolism, excretion, and toxicity – structure-activity relationship) profiles of synthesized surfactants were generated using admetSAR (v. 1.0). The cetrimonium drugs exhibited better profiles than the corresponding pure drugs, saving the aqueous solubility, which was reduced due to the hydrophobicity of counterions.
format Article
author Hussain Shah, Syed Waqar
Bibi, Iram
Yousaf, Sabat
author_facet Hussain Shah, Syed Waqar
Bibi, Iram
Yousaf, Sabat
author_sort Hussain Shah, Syed Waqar
title Cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / Syed Waqar Hussain Shah, Iram Bibi and Sabat Yousaf
title_short Cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / Syed Waqar Hussain Shah, Iram Bibi and Sabat Yousaf
title_full Cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / Syed Waqar Hussain Shah, Iram Bibi and Sabat Yousaf
title_fullStr Cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / Syed Waqar Hussain Shah, Iram Bibi and Sabat Yousaf
title_full_unstemmed Cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / Syed Waqar Hussain Shah, Iram Bibi and Sabat Yousaf
title_sort cetrimonium surfactants with biologically active counter ions as self-immolative drug delivery systems / syed waqar hussain shah, iram bibi and sabat yousaf
publisher Universiti Teknologi MARA
publishDate 2022
url https://ir.uitm.edu.my/id/eprint/58236/1/58236.pdf
https://ir.uitm.edu.my/id/eprint/58236/
https://scilett-fsg.uitm.edu.my/
_version_ 1731229115791441920
score 13.211869

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