Staff View: Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]

Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]

Academic achievement may be influenced by catechol-O-methyltransferase (COMT) polymorphism. A common functional polymorphism of COMT, the rs4680 is consistently being involved in the modulation of dopaminergic pathway and prefrontal cortex function which may predominantly affect cognitive functions....

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Main Authors:	Rosli, Norsuhaila Rosmimi, Anuar, Tengku Shahrul, Adenan, Mohd Ilham, Mohd Janor, Roziah, Ahmad, Rohana, Teh, Lay Kek, Salleh, Mohd Zaki, Abu Bakar, Sahol Hamid, James, Richard Johari
Format:	Article
Language:	English
Published:	Universiti Teknologi MARA 2021
Subjects:	Performance. Competence. Academic achievement Individuality School life. Student manners and customs. Students
Online Access:	http://ir.uitm.edu.my/id/eprint/49119/1/49119.pdf http://ir.uitm.edu.my/id/eprint/49119/ https://scilett-fsg.uitm.edu.my
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id	my.uitm.ir.49119
record_format	eprints
spelling	my.uitm.ir.491192021-07-30T03:38:33Z http://ir.uitm.edu.my/id/eprint/49119/ Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.] Rosli, Norsuhaila Rosmimi Anuar, Tengku Shahrul Adenan, Mohd Ilham Mohd Janor, Roziah Ahmad, Rohana Teh, Lay Kek Salleh, Mohd Zaki Abu Bakar, Sahol Hamid James, Richard Johari Performance. Competence. Academic achievement Individuality School life. Student manners and customs. Students Academic achievement may be influenced by catechol-O-methyltransferase (COMT) polymorphism. A common functional polymorphism of COMT, the rs4680 is consistently being involved in the modulation of dopaminergic pathway and prefrontal cortex function which may predominantly affect cognitive functions. A total of 197 female participants were recruited in this study. The score of student’s grade point average (GPA) from the latest previous semester was used as the measurement of academic achievement. The COMT polymorphism was genotyped using tetra primer allele specific polymerase chain reaction. The findings indicated that there were 8 (4.1 %), 72 (36.5 %), and 117 (59.4 %) participants harbouring Met/Met, Met/Val, and Val/Val genotype for COMT polymorphism respectively. All the genotype distributions of COMT polymorphism were consistent with Hardy-Weinberg equilibrium (χ2 = 0.495, p > 0.05). The one-way analysis of variance (ANOVA) result demonstrated that participants bearing Met/Met genotype had a better achievement in GPA as compared to the other COMT genotypes (p = 0.001). These findings support evidence that the affective role of COMT polymorphism might overwhelm cognitive abilities in measures of academic achievement like GPA. Universiti Teknologi MARA 2021-06 Article PeerReviewed text en http://ir.uitm.edu.my/id/eprint/49119/1/49119.pdf ID49119 Rosli, Norsuhaila Rosmimi and Anuar, Tengku Shahrul and Adenan, Mohd Ilham and Mohd Janor, Roziah and Ahmad, Rohana and Teh, Lay Kek and Salleh, Mohd Zaki and Abu Bakar, Sahol Hamid and James, Richard Johari (2021) Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]. Science Letters (ScL), 15 (2). pp. 90-101. ISSN 2682-8626 https://scilett-fsg.uitm.edu.my
institution	Universiti Teknologi Mara
building	Tun Abdul Razak Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Mara
content_source	UiTM Institutional Repository
url_provider	http://ir.uitm.edu.my/
language	English
topic	Performance. Competence. Academic achievement Individuality School life. Student manners and customs. Students
spellingShingle	Performance. Competence. Academic achievement Individuality School life. Student manners and customs. Students Rosli, Norsuhaila Rosmimi Anuar, Tengku Shahrul Adenan, Mohd Ilham Mohd Janor, Roziah Ahmad, Rohana Teh, Lay Kek Salleh, Mohd Zaki Abu Bakar, Sahol Hamid James, Richard Johari Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]
description	Academic achievement may be influenced by catechol-O-methyltransferase (COMT) polymorphism. A common functional polymorphism of COMT, the rs4680 is consistently being involved in the modulation of dopaminergic pathway and prefrontal cortex function which may predominantly affect cognitive functions. A total of 197 female participants were recruited in this study. The score of student’s grade point average (GPA) from the latest previous semester was used as the measurement of academic achievement. The COMT polymorphism was genotyped using tetra primer allele specific polymerase chain reaction. The findings indicated that there were 8 (4.1 %), 72 (36.5 %), and 117 (59.4 %) participants harbouring Met/Met, Met/Val, and Val/Val genotype for COMT polymorphism respectively. All the genotype distributions of COMT polymorphism were consistent with Hardy-Weinberg equilibrium (χ2 = 0.495, p > 0.05). The one-way analysis of variance (ANOVA) result demonstrated that participants bearing Met/Met genotype had a better achievement in GPA as compared to the other COMT genotypes (p = 0.001). These findings support evidence that the affective role of COMT polymorphism might overwhelm cognitive abilities in measures of academic achievement like GPA.
format	Article
author	Rosli, Norsuhaila Rosmimi Anuar, Tengku Shahrul Adenan, Mohd Ilham Mohd Janor, Roziah Ahmad, Rohana Teh, Lay Kek Salleh, Mohd Zaki Abu Bakar, Sahol Hamid James, Richard Johari
author_facet	Rosli, Norsuhaila Rosmimi Anuar, Tengku Shahrul Adenan, Mohd Ilham Mohd Janor, Roziah Ahmad, Rohana Teh, Lay Kek Salleh, Mohd Zaki Abu Bakar, Sahol Hamid James, Richard Johari
author_sort	Rosli, Norsuhaila Rosmimi
title	Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]
title_short	Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]
title_full	Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]
title_fullStr	Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]
title_full_unstemmed	Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]
title_sort	association of comt polymorphism and academic achievement among female undergraduate students / norsuhaila rosmimi rosli ...[et al.]
publisher	Universiti Teknologi MARA
publishDate	2021
url	http://ir.uitm.edu.my/id/eprint/49119/1/49119.pdf http://ir.uitm.edu.my/id/eprint/49119/ https://scilett-fsg.uitm.edu.my
_version_	1706960471338254336
score	13.211869

Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]

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