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Evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / Noorul Aniesa Mohd Azlie

Issues on emergence of drug resistance bacteria has become a serious problem which lead to the development of drugs in the pharmaceutical industry. The aim of this study is to screen for antimicrobial properties of newly synthetic drugs called β,β-diketoester between different types of pathogenic mi...

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Main Author: Mohd Azlie, Noorul Aniesa
Format: Student Project
Language:English
Published: 2019
Subjects:
Laboratories. General works
Bacteria
Online Access:http://ir.uitm.edu.my/id/eprint/43795/1/43795.pdf
http://ir.uitm.edu.my/id/eprint/43795/
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spelling my.uitm.ir.437952021-03-23T02:27:35Z http://ir.uitm.edu.my/id/eprint/43795/ Evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / Noorul Aniesa Mohd Azlie Mohd Azlie, Noorul Aniesa Laboratories. General works Bacteria Issues on emergence of drug resistance bacteria has become a serious problem which lead to the development of drugs in the pharmaceutical industry. The aim of this study is to screen for antimicrobial properties of newly synthetic drugs called β,β-diketoester between different types of pathogenic microbes including Bacillus cereus (B. cereus), Bacillus subtilis (B. subtilis), Eschericia coli (E. coli), Klebsiella pneumonia (K. preumoniae), Rhizopus and Candida albicans in different type of concentration (12.5mg/ml, 25mg/ml, 50mg/ml and 100mg/ml) while determining the quorum sensing activity of the different concentration of the compound by measuring the inhibition zone of Pseudomonas aeruginosa (P. aeruginosa) as well as evaluating the toxicity of the compound β,β-diketoester using brine shrimp lethality test. The result of this study demonstrated that β,β-diketoester is effective in inhibiting the growth of B. subtilis, B. cereus, K. pneumonia and Rhizopus at all concentration ranging from 12.5mg/ml to 100mg/ml. This study also showed that the compound failed to display any antimicrobial properties against E. coli and Candida albicans. Not only that, β,β-diketoester also inhibit quorum sensing activity in P. aeruginosa in concentration of 25mg/ml, 50mg/ml and 100mg/ml while having the LC50 at concentration of 50mg/ml. In conclusion, the compound β,β-diketoester possessed good antimicrobial activity and anti-quorum sensing activity while showing along non-toxic properties. 2019 Student Project NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/43795/1/43795.pdf Mohd Azlie, Noorul Aniesa (2019) Evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / Noorul Aniesa Mohd Azlie. [Student Project] (Unpublished)
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Laboratories. General works
Bacteria
spellingShingle Laboratories. General works
Bacteria
Mohd Azlie, Noorul Aniesa
Evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / Noorul Aniesa Mohd Azlie
description Issues on emergence of drug resistance bacteria has become a serious problem which lead to the development of drugs in the pharmaceutical industry. The aim of this study is to screen for antimicrobial properties of newly synthetic drugs called β,β-diketoester between different types of pathogenic microbes including Bacillus cereus (B. cereus), Bacillus subtilis (B. subtilis), Eschericia coli (E. coli), Klebsiella pneumonia (K. preumoniae), Rhizopus and Candida albicans in different type of concentration (12.5mg/ml, 25mg/ml, 50mg/ml and 100mg/ml) while determining the quorum sensing activity of the different concentration of the compound by measuring the inhibition zone of Pseudomonas aeruginosa (P. aeruginosa) as well as evaluating the toxicity of the compound β,β-diketoester using brine shrimp lethality test. The result of this study demonstrated that β,β-diketoester is effective in inhibiting the growth of B. subtilis, B. cereus, K. pneumonia and Rhizopus at all concentration ranging from 12.5mg/ml to 100mg/ml. This study also showed that the compound failed to display any antimicrobial properties against E. coli and Candida albicans. Not only that, β,β-diketoester also inhibit quorum sensing activity in P. aeruginosa in concentration of 25mg/ml, 50mg/ml and 100mg/ml while having the LC50 at concentration of 50mg/ml. In conclusion, the compound β,β-diketoester possessed good antimicrobial activity and anti-quorum sensing activity while showing along non-toxic properties.
format Student Project
author Mohd Azlie, Noorul Aniesa
author_facet Mohd Azlie, Noorul Aniesa
author_sort Mohd Azlie, Noorul Aniesa
title Evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / Noorul Aniesa Mohd Azlie
title_short Evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / Noorul Aniesa Mohd Azlie
title_full Evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / Noorul Aniesa Mohd Azlie
title_fullStr Evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / Noorul Aniesa Mohd Azlie
title_full_unstemmed Evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / Noorul Aniesa Mohd Azlie
title_sort evaluation of antimicrobial activity and anti-quorum sensing of derivatives β,β -diketoester and its toxicity activity / noorul aniesa mohd azlie
publishDate 2019
url http://ir.uitm.edu.my/id/eprint/43795/1/43795.pdf
http://ir.uitm.edu.my/id/eprint/43795/
_version_ 1695534711718281216
score 13.211869

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