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Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari

Several Betulinic acid peptides here synthesized by incorporating BA with neutral amino acids using standard coupling protocols in the presence of HoBt, HBtu and DiPEA. In addition enantiopure betulinic-acid- cyclohexene silyl ether peptides was successly synthesized in a good yield. Futher olefinic...

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Main Author: Zahari, Habsah
Format: Thesis
Language:English
Published: 2017
Subjects:
Indexes (General)
Biochemistry
Peptides. Amino acid sequence
Online Access:https://ir.uitm.edu.my/id/eprint/37162/1/37162.pdf
https://ir.uitm.edu.my/id/eprint/37162/
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spelling my.uitm.ir.371622022-09-26T03:17:38Z https://ir.uitm.edu.my/id/eprint/37162/ Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari Zahari, Habsah Indexes (General) Biochemistry Peptides. Amino acid sequence Several Betulinic acid peptides here synthesized by incorporating BA with neutral amino acids using standard coupling protocols in the presence of HoBt, HBtu and DiPEA. In addition enantiopure betulinic-acid- cyclohexene silyl ether peptides was successly synthesized in a good yield. Futher olefinic cleavage reaction, afforded betulinic acid -y- butylrolactone peptides, which undergoes benzylation reaction to furnish desired end product benzylated BA-y-butylrolactone product. Five new synthesized betulinic acid derivatives were tested for their in vitro cytotoxicity against human corrected carainoma cell lines ( HT116). The result of preliminary biological activities showed that three compounds betulinic acid-cyclohexene silyl ether peptides, benzylated betulinic acid-alanine peptide, and benzylated betulinic acid-y-butylrolactone peptides with more hydrosolubility compare to betulinic acid, possessed impressive cytotoxicity with the IC50 values of 50.00, 36.67, 25.33 (ug/ml) respectively 2017 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/37162/1/37162.pdf Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari. (2017) Masters thesis, thesis, Universiti Teknologi MARA (UiTM).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Indexes (General)
Biochemistry
Peptides. Amino acid sequence
spellingShingle Indexes (General)
Biochemistry
Peptides. Amino acid sequence
Zahari, Habsah
Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
description Several Betulinic acid peptides here synthesized by incorporating BA with neutral amino acids using standard coupling protocols in the presence of HoBt, HBtu and DiPEA. In addition enantiopure betulinic-acid- cyclohexene silyl ether peptides was successly synthesized in a good yield. Futher olefinic cleavage reaction, afforded betulinic acid -y- butylrolactone peptides, which undergoes benzylation reaction to furnish desired end product benzylated BA-y-butylrolactone product. Five new synthesized betulinic acid derivatives were tested for their in vitro cytotoxicity against human corrected carainoma cell lines ( HT116). The result of preliminary biological activities showed that three compounds betulinic acid-cyclohexene silyl ether peptides, benzylated betulinic acid-alanine peptide, and benzylated betulinic acid-y-butylrolactone peptides with more hydrosolubility compare to betulinic acid, possessed impressive cytotoxicity with the IC50 values of 50.00, 36.67, 25.33 (ug/ml) respectively
format Thesis
author Zahari, Habsah
author_facet Zahari, Habsah
author_sort Zahari, Habsah
title Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_short Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_full Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_fullStr Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_full_unstemmed Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_sort synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / habsah zahari
publishDate 2017
url https://ir.uitm.edu.my/id/eprint/37162/1/37162.pdf
https://ir.uitm.edu.my/id/eprint/37162/
_version_ 1745565268325695488
score 13.211869

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