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Morus alba L. : creating miles of smiles / Nurhayati Mohamad Zain … [et al.]

The aims of the study are to determine the antimicrobial and antibiofilm activities of M. alba leaves extract against Streptococcus mutans (S.mutans). Method: The antimicrobial activity was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The antib...

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Main Authors: Mohamad Zain, Nurhayati, Mohd Amin, Indah, Ahmad, Vivi Noryati, Mohd Hairi, Nur Haleesa, Mahadzir, Noor Izzyani
Format: Conference or Workshop Item
Language:English
Published: 2019
Subjects:
Oral and dental medicine. Pathology. Diseases
Online Access:http://ir.uitm.edu.my/id/eprint/30160/1/K_NURHAYATI%20MOHAMAD%20ZAIN%20DSSS%20B%2019.pdf
http://ir.uitm.edu.my/id/eprint/30160/
https://dentistry.uitm.edu.my/v2/images/images/DSS/proceeding/vol1/pdf/09.pdf?
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spelling my.uitm.ir.301602020-04-23T03:17:54Z http://ir.uitm.edu.my/id/eprint/30160/ Morus alba L. : creating miles of smiles / Nurhayati Mohamad Zain … [et al.] Mohamad Zain, Nurhayati Mohd Amin, Indah Ahmad, Vivi Noryati Mohd Hairi, Nur Haleesa Mahadzir, Noor Izzyani Oral and dental medicine. Pathology. Diseases The aims of the study are to determine the antimicrobial and antibiofilm activities of M. alba leaves extract against Streptococcus mutans (S.mutans). Method: The antimicrobial activity was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The antibiofilm potential of extract was evaluated using biofilm inhibition assay and biofilm eradication assay. Oradex mouthwash with 0.12% CHX was used as a positive control. All experiments were performed in triplicate and repeated four times independently. Data were analysed using SPSS software version 23. A Kruskal-Wallis test followed by post-hoc Mann-Whitney U test was applied and level of significance was set at P < 0.001. Results: Morus alba (M.alba) leaves extract showed antimicrobial activity against S.mutans with MIC and MBC, 25mg/ml and 50mg/ml respectively. The adherence of bacteria on extract treated surface (0.5x MIC) was significantly reduced with adherence inhibition percentage of 72.5% compared to positive control CHX 0.12% (63%). At 0.5x MIC concentration, the extract also disrupted preformed biofilms with eradication percentage of 52.87%. Conclusion: The results suggest that M. alba leaves extract represents an untapped source of local plant with antibiofilm activity against S.mutans that could be a resource in the development of therapeutic natural products in managing dental caries. 2019 Conference or Workshop Item PeerReviewed text en http://ir.uitm.edu.my/id/eprint/30160/1/K_NURHAYATI%20MOHAMAD%20ZAIN%20DSSS%20B%2019.pdf Mohamad Zain, Nurhayati and Mohd Amin, Indah and Ahmad, Vivi Noryati and Mohd Hairi, Nur Haleesa and Mahadzir, Noor Izzyani (2019) Morus alba L. : creating miles of smiles / Nurhayati Mohamad Zain … [et al.]. In: Proceedings of 9th Dental Student’s Scientific Symposium,Malaysia (Malaysia, 2019), 9th – 10th April 2019, Faculty Dentistry, Universiti Teknologi MARA. https://dentistry.uitm.edu.my/v2/images/images/DSS/proceeding/vol1/pdf/09.pdf?
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Oral and dental medicine. Pathology. Diseases
spellingShingle Oral and dental medicine. Pathology. Diseases
Mohamad Zain, Nurhayati
Mohd Amin, Indah
Ahmad, Vivi Noryati
Mohd Hairi, Nur Haleesa
Mahadzir, Noor Izzyani
Morus alba L. : creating miles of smiles / Nurhayati Mohamad Zain … [et al.]
description The aims of the study are to determine the antimicrobial and antibiofilm activities of M. alba leaves extract against Streptococcus mutans (S.mutans). Method: The antimicrobial activity was evaluated using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The antibiofilm potential of extract was evaluated using biofilm inhibition assay and biofilm eradication assay. Oradex mouthwash with 0.12% CHX was used as a positive control. All experiments were performed in triplicate and repeated four times independently. Data were analysed using SPSS software version 23. A Kruskal-Wallis test followed by post-hoc Mann-Whitney U test was applied and level of significance was set at P < 0.001. Results: Morus alba (M.alba) leaves extract showed antimicrobial activity against S.mutans with MIC and MBC, 25mg/ml and 50mg/ml respectively. The adherence of bacteria on extract treated surface (0.5x MIC) was significantly reduced with adherence inhibition percentage of 72.5% compared to positive control CHX 0.12% (63%). At 0.5x MIC concentration, the extract also disrupted preformed biofilms with eradication percentage of 52.87%. Conclusion: The results suggest that M. alba leaves extract represents an untapped source of local plant with antibiofilm activity against S.mutans that could be a resource in the development of therapeutic natural products in managing dental caries.
format Conference or Workshop Item
author Mohamad Zain, Nurhayati
Mohd Amin, Indah
Ahmad, Vivi Noryati
Mohd Hairi, Nur Haleesa
Mahadzir, Noor Izzyani
author_facet Mohamad Zain, Nurhayati
Mohd Amin, Indah
Ahmad, Vivi Noryati
Mohd Hairi, Nur Haleesa
Mahadzir, Noor Izzyani
author_sort Mohamad Zain, Nurhayati
title Morus alba L. : creating miles of smiles / Nurhayati Mohamad Zain … [et al.]
title_short Morus alba L. : creating miles of smiles / Nurhayati Mohamad Zain … [et al.]
title_full Morus alba L. : creating miles of smiles / Nurhayati Mohamad Zain … [et al.]
title_fullStr Morus alba L. : creating miles of smiles / Nurhayati Mohamad Zain … [et al.]
title_full_unstemmed Morus alba L. : creating miles of smiles / Nurhayati Mohamad Zain … [et al.]
title_sort morus alba l. : creating miles of smiles / nurhayati mohamad zain … [et al.]
publishDate 2019
url http://ir.uitm.edu.my/id/eprint/30160/1/K_NURHAYATI%20MOHAMAD%20ZAIN%20DSSS%20B%2019.pdf
http://ir.uitm.edu.my/id/eprint/30160/
https://dentistry.uitm.edu.my/v2/images/images/DSS/proceeding/vol1/pdf/09.pdf?
_version_ 1685650616833015808
score 13.211869

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