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The effect of Pre-operative Neutrophil-Lymphocyte Ratio on outcome post Coronary Artery Bypass Graft (CABG) Surgery / Roihan Awg Isa

BACKGROUND: Neutrophils-Lymphocyte ratio (NLR) is an emerging biomarker of inflammation to predict major cardiovascular adverse outcomes, particularly in cardiovascular surgeries. OBJECTIVES: This study aimed to determine the association between pre-operative Neutrophil-Lymphocyte Ratio (NLR) to o...

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Main Author: Awg Isa, Roihan
Format: Thesis
Language:English
Published: 2019
Subjects:
Vascular System
Immunology
Diseases of the circulatory (Cardiovascular) system
Online Access:https://ir.uitm.edu.my/id/eprint/29730/1/29730.pdf
https://ir.uitm.edu.my/id/eprint/29730/
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spelling my.uitm.ir.297302022-07-16T15:46:01Z https://ir.uitm.edu.my/id/eprint/29730/ The effect of Pre-operative Neutrophil-Lymphocyte Ratio on outcome post Coronary Artery Bypass Graft (CABG) Surgery / Roihan Awg Isa Awg Isa, Roihan Vascular System Immunology Diseases of the circulatory (Cardiovascular) system BACKGROUND: Neutrophils-Lymphocyte ratio (NLR) is an emerging biomarker of inflammation to predict major cardiovascular adverse outcomes, particularly in cardiovascular surgeries. OBJECTIVES: This study aimed to determine the association between pre-operative Neutrophil-Lymphocyte Ratio (NLR) to outcomes post-coronary artery bypass graft (CABG) surgery. METHODS: A retrospective cohort study of 137 patients who undergone coronary artery bypass graft (CABG) surgery in the Cardiothoracic department, Specialist Centre, UiTM from Jun 2013 to December 2017 was conducted. Data were extracted from medical records and laboratory databases. The statistical analysis was performed with simple logistic regression coefficient test, by using the Statistical Package for Social Sciences software (IBM SPSS 22.0 for Windows RESULTS: Patients with higher level of pre-operative NLR >2.5 had significantly longer ICU stay of more than 3 days (Odd Ratio (OR) (95%CI):0.13(0.04,0.39), p<0.001, and longer hospitalization more than 7 days (OR (95%CI: 0.29(0.14,0.62), p=0.001).However, there was no association between pre-operative NLR and mortality rate. CONCLUSIONS: Elevated pre-operative NLR predicted statistically significant higher patient morbidity and mortality rates. The NLR is also a reliable and inexpensive biomarker, easily available on routine full blood count test. It can be incorporated as part of a management algorithm for patients undergoing cardiac surgery. 2019-05 Thesis PeerReviewed text en https://ir.uitm.edu.my/id/eprint/29730/1/29730.pdf The effect of Pre-operative Neutrophil-Lymphocyte Ratio on outcome post Coronary Artery Bypass Graft (CABG) Surgery / Roihan Awg Isa. (2019) Masters thesis, thesis, Universiti Teknologi MARA (Kampus Sg. Buloh).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Vascular System
Immunology
Diseases of the circulatory (Cardiovascular) system
spellingShingle Vascular System
Immunology
Diseases of the circulatory (Cardiovascular) system
Awg Isa, Roihan
The effect of Pre-operative Neutrophil-Lymphocyte Ratio on outcome post Coronary Artery Bypass Graft (CABG) Surgery / Roihan Awg Isa
description BACKGROUND: Neutrophils-Lymphocyte ratio (NLR) is an emerging biomarker of inflammation to predict major cardiovascular adverse outcomes, particularly in cardiovascular surgeries. OBJECTIVES: This study aimed to determine the association between pre-operative Neutrophil-Lymphocyte Ratio (NLR) to outcomes post-coronary artery bypass graft (CABG) surgery. METHODS: A retrospective cohort study of 137 patients who undergone coronary artery bypass graft (CABG) surgery in the Cardiothoracic department, Specialist Centre, UiTM from Jun 2013 to December 2017 was conducted. Data were extracted from medical records and laboratory databases. The statistical analysis was performed with simple logistic regression coefficient test, by using the Statistical Package for Social Sciences software (IBM SPSS 22.0 for Windows RESULTS: Patients with higher level of pre-operative NLR >2.5 had significantly longer ICU stay of more than 3 days (Odd Ratio (OR) (95%CI):0.13(0.04,0.39), p<0.001, and longer hospitalization more than 7 days (OR (95%CI: 0.29(0.14,0.62), p=0.001).However, there was no association between pre-operative NLR and mortality rate. CONCLUSIONS: Elevated pre-operative NLR predicted statistically significant higher patient morbidity and mortality rates. The NLR is also a reliable and inexpensive biomarker, easily available on routine full blood count test. It can be incorporated as part of a management algorithm for patients undergoing cardiac surgery.
format Thesis
author Awg Isa, Roihan
author_facet Awg Isa, Roihan
author_sort Awg Isa, Roihan
title The effect of Pre-operative Neutrophil-Lymphocyte Ratio on outcome post Coronary Artery Bypass Graft (CABG) Surgery / Roihan Awg Isa
title_short The effect of Pre-operative Neutrophil-Lymphocyte Ratio on outcome post Coronary Artery Bypass Graft (CABG) Surgery / Roihan Awg Isa
title_full The effect of Pre-operative Neutrophil-Lymphocyte Ratio on outcome post Coronary Artery Bypass Graft (CABG) Surgery / Roihan Awg Isa
title_fullStr The effect of Pre-operative Neutrophil-Lymphocyte Ratio on outcome post Coronary Artery Bypass Graft (CABG) Surgery / Roihan Awg Isa
title_full_unstemmed The effect of Pre-operative Neutrophil-Lymphocyte Ratio on outcome post Coronary Artery Bypass Graft (CABG) Surgery / Roihan Awg Isa
title_sort effect of pre-operative neutrophil-lymphocyte ratio on outcome post coronary artery bypass graft (cabg) surgery / roihan awg isa
publishDate 2019
url https://ir.uitm.edu.my/id/eprint/29730/1/29730.pdf
https://ir.uitm.edu.my/id/eprint/29730/
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score 13.211869

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