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Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli

Conventional alginate pellets underwent rapid drug dissolution and failed to exert colon targeting unless subjected to complex coating. This study designed coatless delayed-release oral colon-specific alginate pellets for ulcerative colitis treatment. Alginate pellets, formulated with water-insolubl...

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Main Author: Md. Ramli, Siti Hajar
Format: Thesis
Language:English
Published: 2016
Subjects:
Bacteria
Online Access:https://ir.uitm.edu.my/id/eprint/27555/1/TM_SITI%20HAJAR%20MD%20RAMLI%20PH%2016_5.pdf
https://ir.uitm.edu.my/id/eprint/27555/
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spelling my.uitm.ir.275552022-06-14T07:14:42Z https://ir.uitm.edu.my/id/eprint/27555/ Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli Md. Ramli, Siti Hajar Bacteria Conventional alginate pellets underwent rapid drug dissolution and failed to exert colon targeting unless subjected to complex coating. This study designed coatless delayed-release oral colon-specific alginate pellets for ulcerative colitis treatment. Alginate pellets, formulated with water-insoluble ethylcellulose and various calcium salts, were prepared using solvent-free melt pelletization technique which prevented reaction between processing materials during agglomeration and allowed such reaction to occur only in dissolution. Combination of acid-soluble calcium carbonate and highly water-soluble calcium acetate did not impart colon-specific characteristics to pellets due to pore formation in fragmented matrices. Combination of moderately water-soluble calcium phosphate and calcium acetate delayed drug release due to rapid alginate crosslinking by soluble calcium from acetate salt followed by sustaining alginate crosslinking by calcium phosphate. The use of 1:3 ethylcellulose-to-alginate enhanced the sustained drug release attribute. The ethylcellulose was able to maintain the pellet integrity without calcium acetate. Using hydrophobic prednisolone as therapeutic, hydrophilic alginate pellets formulated with hydrophobic ethylcellulose and moderately polar calcium phosphate exhibited colon-specific in vitro drug release and in vivo anti-inflammatory action. Coatless oral colon-specific alginate pellets can be designed through optimal formulation with melt pelletization as the processing technology. 2016 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/27555/1/TM_SITI%20HAJAR%20MD%20RAMLI%20PH%2016_5.pdf Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli. (2016) Masters thesis, thesis, Universiti Teknologi MARA.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Bacteria
spellingShingle Bacteria
Md. Ramli, Siti Hajar
Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
description Conventional alginate pellets underwent rapid drug dissolution and failed to exert colon targeting unless subjected to complex coating. This study designed coatless delayed-release oral colon-specific alginate pellets for ulcerative colitis treatment. Alginate pellets, formulated with water-insoluble ethylcellulose and various calcium salts, were prepared using solvent-free melt pelletization technique which prevented reaction between processing materials during agglomeration and allowed such reaction to occur only in dissolution. Combination of acid-soluble calcium carbonate and highly water-soluble calcium acetate did not impart colon-specific characteristics to pellets due to pore formation in fragmented matrices. Combination of moderately water-soluble calcium phosphate and calcium acetate delayed drug release due to rapid alginate crosslinking by soluble calcium from acetate salt followed by sustaining alginate crosslinking by calcium phosphate. The use of 1:3 ethylcellulose-to-alginate enhanced the sustained drug release attribute. The ethylcellulose was able to maintain the pellet integrity without calcium acetate. Using hydrophobic prednisolone as therapeutic, hydrophilic alginate pellets formulated with hydrophobic ethylcellulose and moderately polar calcium phosphate exhibited colon-specific in vitro drug release and in vivo anti-inflammatory action. Coatless oral colon-specific alginate pellets can be designed through optimal formulation with melt pelletization as the processing technology.
format Thesis
author Md. Ramli, Siti Hajar
author_facet Md. Ramli, Siti Hajar
author_sort Md. Ramli, Siti Hajar
title Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_short Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_full Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_fullStr Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_full_unstemmed Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_sort coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / siti hajar md. ramli
publishDate 2016
url https://ir.uitm.edu.my/id/eprint/27555/1/TM_SITI%20HAJAR%20MD%20RAMLI%20PH%2016_5.pdf
https://ir.uitm.edu.my/id/eprint/27555/
_version_ 1736837209334480896
score 13.211869

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