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The efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / Dr. Sabrina Ab Wahab

Background and Aims. Cellulitis causes local residual inflammation which delays the resolution of signs and symptoms and may require prolonged hospitalization. Studies have shown that super-oxidised hydrogel and solution improves healing and acts as antimicrobial in skin and soft tissue infection. P...

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Main Author: Ab Wahab, Sabrina
Format: Thesis
Language:English
Published: 2017
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Salts
Online Access:https://ir.uitm.edu.my/id/eprint/26959/1/TM_SABRINA%20AB%20WAHAB%20MD%2017_5.pdf
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spelling my.uitm.ir.269592022-06-21T08:05:03Z https://ir.uitm.edu.my/id/eprint/26959/ The efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / Dr. Sabrina Ab Wahab Ab Wahab, Sabrina Salts Background and Aims. Cellulitis causes local residual inflammation which delays the resolution of signs and symptoms and may require prolonged hospitalization. Studies have shown that super-oxidised hydrogel and solution improves healing and acts as antimicrobial in skin and soft tissue infection. Potassium permanganate dressing has been widely used as a reliable antiseptic. Thus, this study is aimed to evaluate the reduction of erythema and oedema; measured as percentage of reduction of total surface area erythema ; and oedema reduction by reduction in limb circumference, at end-of-treatment (day 3 and/or day 7). Secondary endpoints include reduction of cellulitis severity score which measures erythema, warmth, tenderness, oedema, ulceration, drainage and fluctuance; at end-of-treatment (day 3 and/or day 7). Methodology. This is a multicentre, prospective, open-label, comparative clinical study involving adults >18 years old, efficacy comparison between two methods of dressing; super-oxidised hydrogel and solution dressing compared to potassium permanganate dressing, in the same patient in Eron Class 1 and 2 limb cellulitis in assessing the reduction of local inflammation. Thirty patients with 2 different sites of cellulitis area in the same patient were enrolled after fulfilling inclusion criteria. All patients received the super-oxidised hydrogel (Dermacyn® WoundCare Hydrogel) combined with solution dressing (Dermacyn® WoundCare Solution) and potassium permanganate (KMnC>4) dilution 1:10000 wet wrap at different areas of the same or different leg for 15 minutes. Results. Study showed that super-oxidised hydrogel and solution dressing was more effective in reducing erythema compared to potassium permanganate dressing alone, with statistically significant difference in percentage of erythema reduction at Day 3 (50.05% vs 30.98%; p=0.001) and at Day 7 (71.10% vs 59.05 %; p=0.M5). Superoxidised hydrogel and solution was also more effective in reducing oedema compared to potassium permanganate dressing alone which was statistically significant, with median reduction in limb circumference at Day 3 (1.90 cm vs 0.80 cm; ^=0.001) and Day 7 (3.00 cm vs 1.80 cm; />=0.021), respectively. There was no difference in both dressing in the reduction of cellulitis severity score (maximum total score of 21), with median reduction of score at Day 3 (6.0 vs 5.5; p=0A23) and Day 7(12.0 vs 11.0; ^=0.567) albeit erythema scores alone showed significant difference (p=0.029). Diabetes mellitus, bullous type cellulitis, and disease recurrence were significant associated factors. Duration of fever, pain and swelling had positive correlation with the percentage of reduction of erythema at Day 3. Conclusion. Super-oxidised hydrogel and solution is more effective in improving local erythema and oedema, as compared to potassium permanganate dressing, in patients with cellulitis albeit no difference in the reduction of total cellulitis severity score. There was improvement of the overall local inflammation with intervention by both methods of dressing in this study. 2017 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/26959/1/TM_SABRINA%20AB%20WAHAB%20MD%2017_5.pdf The efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / Dr. Sabrina Ab Wahab. (2017) Masters thesis, thesis, Universiti Teknologi MARA.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Salts
spellingShingle Salts
Ab Wahab, Sabrina
The efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / Dr. Sabrina Ab Wahab
description Background and Aims. Cellulitis causes local residual inflammation which delays the resolution of signs and symptoms and may require prolonged hospitalization. Studies have shown that super-oxidised hydrogel and solution improves healing and acts as antimicrobial in skin and soft tissue infection. Potassium permanganate dressing has been widely used as a reliable antiseptic. Thus, this study is aimed to evaluate the reduction of erythema and oedema; measured as percentage of reduction of total surface area erythema ; and oedema reduction by reduction in limb circumference, at end-of-treatment (day 3 and/or day 7). Secondary endpoints include reduction of cellulitis severity score which measures erythema, warmth, tenderness, oedema, ulceration, drainage and fluctuance; at end-of-treatment (day 3 and/or day 7). Methodology. This is a multicentre, prospective, open-label, comparative clinical study involving adults >18 years old, efficacy comparison between two methods of dressing; super-oxidised hydrogel and solution dressing compared to potassium permanganate dressing, in the same patient in Eron Class 1 and 2 limb cellulitis in assessing the reduction of local inflammation. Thirty patients with 2 different sites of cellulitis area in the same patient were enrolled after fulfilling inclusion criteria. All patients received the super-oxidised hydrogel (Dermacyn® WoundCare Hydrogel) combined with solution dressing (Dermacyn® WoundCare Solution) and potassium permanganate (KMnC>4) dilution 1:10000 wet wrap at different areas of the same or different leg for 15 minutes. Results. Study showed that super-oxidised hydrogel and solution dressing was more effective in reducing erythema compared to potassium permanganate dressing alone, with statistically significant difference in percentage of erythema reduction at Day 3 (50.05% vs 30.98%; p=0.001) and at Day 7 (71.10% vs 59.05 %; p=0.M5). Superoxidised hydrogel and solution was also more effective in reducing oedema compared to potassium permanganate dressing alone which was statistically significant, with median reduction in limb circumference at Day 3 (1.90 cm vs 0.80 cm; ^=0.001) and Day 7 (3.00 cm vs 1.80 cm; />=0.021), respectively. There was no difference in both dressing in the reduction of cellulitis severity score (maximum total score of 21), with median reduction of score at Day 3 (6.0 vs 5.5; p=0A23) and Day 7(12.0 vs 11.0; ^=0.567) albeit erythema scores alone showed significant difference (p=0.029). Diabetes mellitus, bullous type cellulitis, and disease recurrence were significant associated factors. Duration of fever, pain and swelling had positive correlation with the percentage of reduction of erythema at Day 3. Conclusion. Super-oxidised hydrogel and solution is more effective in improving local erythema and oedema, as compared to potassium permanganate dressing, in patients with cellulitis albeit no difference in the reduction of total cellulitis severity score. There was improvement of the overall local inflammation with intervention by both methods of dressing in this study.
format Thesis
author Ab Wahab, Sabrina
author_facet Ab Wahab, Sabrina
author_sort Ab Wahab, Sabrina
title The efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / Dr. Sabrina Ab Wahab
title_short The efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / Dr. Sabrina Ab Wahab
title_full The efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / Dr. Sabrina Ab Wahab
title_fullStr The efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / Dr. Sabrina Ab Wahab
title_full_unstemmed The efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / Dr. Sabrina Ab Wahab
title_sort efficacy of super-oxidised hydrogel and solution compared to potassium permanganate dressing for the management of cellulitis / dr. sabrina ab wahab
publishDate 2017
url https://ir.uitm.edu.my/id/eprint/26959/1/TM_SABRINA%20AB%20WAHAB%20MD%2017_5.pdf
https://ir.uitm.edu.my/id/eprint/26959/
_version_ 1736837202234572800
score 13.211869

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