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Microbial transformation of steroid / Balqis Haya Ismail

Microbial transformation by endophytes was studied since centuries ago. This phenomenon allows a compound to be modified into another compound by using green synthesis instead of chemical synthesis. In this study, Mesterolone as the substrate undergoes fermentation with identified Aspergillus SSW...

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Main Author: Ismail, Balqis Haya
Format: Thesis
Language:English
Published: Faculty of Pharmacy 2010
Subjects:
RM Therapeutics. Pharmacology
Online Access:http://ir.uitm.edu.my/id/eprint/2207/1/TD_BALQIS%20HAYA%20ISMAIL%2010_5%201.pdf
http://ir.uitm.edu.my/id/eprint/2207/
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spelling my.uitm.ir.22072016-10-11T08:15:58Z http://ir.uitm.edu.my/id/eprint/2207/ Microbial transformation of steroid / Balqis Haya Ismail Ismail, Balqis Haya RM Therapeutics. Pharmacology Microbial transformation by endophytes was studied since centuries ago. This phenomenon allows a compound to be modified into another compound by using green synthesis instead of chemical synthesis. In this study, Mesterolone as the substrate undergoes fermentation with identified Aspergillus SSW and 11L2. Outline of method involved are media preparation, inoculation of fungi, feeding of substrate, incubation for 6 or 12 days and extraction using ethyl acetate. The extracts were analyzed using TLC and HPLC to indicate the biotransformed products. Besides that, each product extracted was also tested for antimicrobial activity by disk diffusion assay, which include activity against bacteria of E. Coli and B. Subtilis as well as fungi represented by A. Niger. Products only by SSW show potential antimicrobial activity. Further study should be done to purify and identify resulting compound Faculty of Pharmacy 2010 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/2207/1/TD_BALQIS%20HAYA%20ISMAIL%2010_5%201.pdf Ismail, Balqis Haya (2010) Microbial transformation of steroid / Balqis Haya Ismail. Degree thesis, Universiti Teknologi MARA.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic RM Therapeutics. Pharmacology
spellingShingle RM Therapeutics. Pharmacology
Ismail, Balqis Haya
Microbial transformation of steroid / Balqis Haya Ismail
description Microbial transformation by endophytes was studied since centuries ago. This phenomenon allows a compound to be modified into another compound by using green synthesis instead of chemical synthesis. In this study, Mesterolone as the substrate undergoes fermentation with identified Aspergillus SSW and 11L2. Outline of method involved are media preparation, inoculation of fungi, feeding of substrate, incubation for 6 or 12 days and extraction using ethyl acetate. The extracts were analyzed using TLC and HPLC to indicate the biotransformed products. Besides that, each product extracted was also tested for antimicrobial activity by disk diffusion assay, which include activity against bacteria of E. Coli and B. Subtilis as well as fungi represented by A. Niger. Products only by SSW show potential antimicrobial activity. Further study should be done to purify and identify resulting compound
format Thesis
author Ismail, Balqis Haya
author_facet Ismail, Balqis Haya
author_sort Ismail, Balqis Haya
title Microbial transformation of steroid / Balqis Haya Ismail
title_short Microbial transformation of steroid / Balqis Haya Ismail
title_full Microbial transformation of steroid / Balqis Haya Ismail
title_fullStr Microbial transformation of steroid / Balqis Haya Ismail
title_full_unstemmed Microbial transformation of steroid / Balqis Haya Ismail
title_sort microbial transformation of steroid / balqis haya ismail
publisher Faculty of Pharmacy
publishDate 2010
url http://ir.uitm.edu.my/id/eprint/2207/1/TD_BALQIS%20HAYA%20ISMAIL%2010_5%201.pdf
http://ir.uitm.edu.my/id/eprint/2207/
_version_ 1685648182618357760
score 13.211869

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