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Study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / Mohd Kamal Nik Hasan

This study was designed in order to investigate the effect of Myrmecodia platytyrea (MyP) extract as an anti-hypercholesterolemic agent. The acute toxicological test was done by administration of single dose and followed by 14 days observation on the rat. The subchronic toxicological test was done b...

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Main Author: Nik Hasan, Mohd Kamal
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2018
Subjects:
Metabolic diseases
Organic materia medica (General)
Online Access:https://ir.uitm.edu.my/id/eprint/20554/1/ABS_MOHD%20KAMAL%20NIK%20HASAN%20TDRA%20VOL%2013%20IGS%2018.pdf
https://ir.uitm.edu.my/id/eprint/20554/
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spelling my.uitm.ir.205542024-03-06T15:43:41Z https://ir.uitm.edu.my/id/eprint/20554/ Study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / Mohd Kamal Nik Hasan Nik Hasan, Mohd Kamal Metabolic diseases Organic materia medica (General) This study was designed in order to investigate the effect of Myrmecodia platytyrea (MyP) extract as an anti-hypercholesterolemic agent. The acute toxicological test was done by administration of single dose and followed by 14 days observation on the rat. The subchronic toxicological test was done by administration of 28 days repeated dose. Both tests showed that MyP water extract was not toxic. The bioassay-guided isolation revealed that the MyP water extract containing 2-(2-methylbutyryl) phloroglucinol glucoside which reduced 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity (p<0.05) with inhibition concentration 50 (IC₅₀) of 75 μg/ml. Besides that, polysaccharide showed effective concentration 50 (EC₅₀) of 50.5 μg/ml for bile acid binding. Meanwhile, rutin actively decreased pancreatic lipase activity with IC₅₀ of 130 μg/ml. Moreover, in vivo study results showed that treatment of MyP water extract can significantly reduce (p<0.05) low-density lipoprotein (LDL) compared to negative control group. The extract significantly increased (p<0.05) high-density lipoproteins (HDL) concentration compared to negative control group. In addition, MyP water extract increased faecal cholesterol and faecal bile compared to normal control group. Lipid peroxidation was significantly decreased (p<0.05) in MyP water extract treatment group. The extract also decreased the formation of the fatty streak at the aorta and significantly decreased (p<0.05) the thickness of foam cell in high cholesterol diet (HCD) induced rat… Institute of Graduate Studies, UiTM 2018 Book Section PeerReviewed text en https://ir.uitm.edu.my/id/eprint/20554/1/ABS_MOHD%20KAMAL%20NIK%20HASAN%20TDRA%20VOL%2013%20IGS%2018.pdf Study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / Mohd Kamal Nik Hasan. (2018) In: The Doctoral Research Abstracts. IGS Biannual Publication, 18 (18). Institute of Graduate Studies, UiTM, Shah Alam.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Metabolic diseases
Organic materia medica (General)
spellingShingle Metabolic diseases
Organic materia medica (General)
Nik Hasan, Mohd Kamal
Study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / Mohd Kamal Nik Hasan
description This study was designed in order to investigate the effect of Myrmecodia platytyrea (MyP) extract as an anti-hypercholesterolemic agent. The acute toxicological test was done by administration of single dose and followed by 14 days observation on the rat. The subchronic toxicological test was done by administration of 28 days repeated dose. Both tests showed that MyP water extract was not toxic. The bioassay-guided isolation revealed that the MyP water extract containing 2-(2-methylbutyryl) phloroglucinol glucoside which reduced 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity (p<0.05) with inhibition concentration 50 (IC₅₀) of 75 μg/ml. Besides that, polysaccharide showed effective concentration 50 (EC₅₀) of 50.5 μg/ml for bile acid binding. Meanwhile, rutin actively decreased pancreatic lipase activity with IC₅₀ of 130 μg/ml. Moreover, in vivo study results showed that treatment of MyP water extract can significantly reduce (p<0.05) low-density lipoprotein (LDL) compared to negative control group. The extract significantly increased (p<0.05) high-density lipoproteins (HDL) concentration compared to negative control group. In addition, MyP water extract increased faecal cholesterol and faecal bile compared to normal control group. Lipid peroxidation was significantly decreased (p<0.05) in MyP water extract treatment group. The extract also decreased the formation of the fatty streak at the aorta and significantly decreased (p<0.05) the thickness of foam cell in high cholesterol diet (HCD) induced rat…
format Book Section
author Nik Hasan, Mohd Kamal
author_facet Nik Hasan, Mohd Kamal
author_sort Nik Hasan, Mohd Kamal
title Study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / Mohd Kamal Nik Hasan
title_short Study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / Mohd Kamal Nik Hasan
title_full Study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / Mohd Kamal Nik Hasan
title_fullStr Study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / Mohd Kamal Nik Hasan
title_full_unstemmed Study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / Mohd Kamal Nik Hasan
title_sort study on myrmecodia platytyrea antoinii tuber and its potential benefits in preventing hypercholesterolemia related diseases / mohd kamal nik hasan
publisher Institute of Graduate Studies, UiTM
publishDate 2018
url https://ir.uitm.edu.my/id/eprint/20554/1/ABS_MOHD%20KAMAL%20NIK%20HASAN%20TDRA%20VOL%2013%20IGS%2018.pdf
https://ir.uitm.edu.my/id/eprint/20554/
_version_ 1793161822761648128
score 13.211869

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