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Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi

Crystallization is a major technological process for particle formations. It is important and widely used in the production of pharmaceutical drugs since most drugs particles are produced in crystalline form. L-isoleucine is one of the drugs that exist in crystalline form and it can be produced thro...

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Main Author: Md Azmi, Nik Salwani
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2017
Subjects:
Malaysia
Online Access:http://ir.uitm.edu.my/id/eprint/19900/2/ABS_NIK%20SALWANI%20MD%20AZMI%20TDRA%20VOL%2012%20IGS%2017.pdf
http://ir.uitm.edu.my/id/eprint/19900/
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spelling my.uitm.ir.199002018-06-08T03:50:31Z http://ir.uitm.edu.my/id/eprint/19900/ Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi Md Azmi, Nik Salwani Malaysia Crystallization is a major technological process for particle formations. It is important and widely used in the production of pharmaceutical drugs since most drugs particles are produced in crystalline form. L-isoleucine is one of the drugs that exist in crystalline form and it can be produced through crystallization process. However, even slight changes in the crystallization condition can drastically alter crystals properties. Control of the process in order to control the physicochemical properties (solubility, morphology, polymorphism) is crucial to produce the right type of crystal. To overcome this problem, electric potential was applied with the intention to control the process. Hence it has become the main objective of this study to determine the effect of electric potential on solubility and mestastable zone width (MSZW) of L-isoleucine crystallization. Solubility of L-isoleucine experiment was conducted using three different methods; (1) Solubility Method A: Gravimetric method, (2) Solubility Method B: Isothermal dissolution and (3) Solubility Method C: Dissolution with controlled heating rate, while polythermal and isothermal method was adopted for the crystallization process. The results showed that all three methods gave significant difference in solubility data. Institute of Graduate Studies, UiTM 2017 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19900/2/ABS_NIK%20SALWANI%20MD%20AZMI%20TDRA%20VOL%2012%20IGS%2017.pdf Md Azmi, Nik Salwani (2017) Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi. In: The Doctoral Research Abstracts. IGS Biannual Publication, 12 (12). Institute of Graduate Studies, UiTM, Shah Alam.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Malaysia
spellingShingle Malaysia
Md Azmi, Nik Salwani
Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi
description Crystallization is a major technological process for particle formations. It is important and widely used in the production of pharmaceutical drugs since most drugs particles are produced in crystalline form. L-isoleucine is one of the drugs that exist in crystalline form and it can be produced through crystallization process. However, even slight changes in the crystallization condition can drastically alter crystals properties. Control of the process in order to control the physicochemical properties (solubility, morphology, polymorphism) is crucial to produce the right type of crystal. To overcome this problem, electric potential was applied with the intention to control the process. Hence it has become the main objective of this study to determine the effect of electric potential on solubility and mestastable zone width (MSZW) of L-isoleucine crystallization. Solubility of L-isoleucine experiment was conducted using three different methods; (1) Solubility Method A: Gravimetric method, (2) Solubility Method B: Isothermal dissolution and (3) Solubility Method C: Dissolution with controlled heating rate, while polythermal and isothermal method was adopted for the crystallization process. The results showed that all three methods gave significant difference in solubility data.
format Book Section
author Md Azmi, Nik Salwani
author_facet Md Azmi, Nik Salwani
author_sort Md Azmi, Nik Salwani
title Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi
title_short Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi
title_full Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi
title_fullStr Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi
title_full_unstemmed Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi
title_sort electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / nik salwani md azmi
publisher Institute of Graduate Studies, UiTM
publishDate 2017
url http://ir.uitm.edu.my/id/eprint/19900/2/ABS_NIK%20SALWANI%20MD%20AZMI%20TDRA%20VOL%2012%20IGS%2017.pdf
http://ir.uitm.edu.my/id/eprint/19900/
_version_ 1685649274006667264
score 13.211869

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