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Cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / Norhafiza Razali

Glaucoma, a common cause of optic neuropathy, is associated with elevated intraocular pressure (IOP) and is the leading cause of irreversible visual disability. Steroid-induced glaucoma, a common type of secondary glaucoma, is also associated with elevated IOP (steroid-induced ocular hypertension (S...

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Main Author: Razali, Norhafiza
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2017
Subjects:
Malaysia
Online Access:http://ir.uitm.edu.my/id/eprint/19794/1/ABS_NORHAFIZA%20RAZALI%20TDRA%20VOL%2011%20IGS%2017.pdf
http://ir.uitm.edu.my/id/eprint/19794/
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spelling my.uitm.ir.197942018-06-08T00:53:52Z http://ir.uitm.edu.my/id/eprint/19794/ Cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / Norhafiza Razali Razali, Norhafiza Malaysia Glaucoma, a common cause of optic neuropathy, is associated with elevated intraocular pressure (IOP) and is the leading cause of irreversible visual disability. Steroid-induced glaucoma, a common type of secondary glaucoma, is also associated with elevated IOP (steroid-induced ocular hypertension (SIOH)). SIOH and glaucoma are currently treated with antiglaucoma agents, which often have suboptimal efficacy and are associated with adverse effects. The objective of this study was to determine if topical application of transresveratrol reduces IOP in rats with SIOH and to investigate its mechanisms of action. This study was divided into in vivo and in vitro studies. In the in vivo study, we evaluated the oculohypotensive effects of topical transresveratrol in normal and SIOH rats and investigated the role of adenosine receptors (ARs) and transforming growth factor-β (TGF-β) signalling in the IOP lowering effect of trans-resveratrol. Involvement of AR was studied by observing the IOP changes in response to trans-resveratrol after pretreating SIOH animals with AR subtype-specific antagonists. The study also investigated phospholipase C (PLC) activation, extracellular regulated kinase 1/2 (ERK1/2) phosphorylation and increased matrix metalloproteinases (MMPs) secretion in the aqueous humour (AH) as mechanism of resveratrolinduced oculohypotension in SIOH rats. In vitro studies evaluated the effect of trans-resveratrol on cellular signalling pathways of ARs and TGF-β in primary human trabecular meshwork cells (HTMCs)… Institute of Graduate Studies, UiTM 2017 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19794/1/ABS_NORHAFIZA%20RAZALI%20TDRA%20VOL%2011%20IGS%2017.pdf Razali, Norhafiza (2017) Cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / Norhafiza Razali. In: The Doctoral Research Abstracts. Professorial Lecture, 11 (11). Institute of Graduate Studies, UiTM, Shah Alam.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Malaysia
spellingShingle Malaysia
Razali, Norhafiza
Cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / Norhafiza Razali
description Glaucoma, a common cause of optic neuropathy, is associated with elevated intraocular pressure (IOP) and is the leading cause of irreversible visual disability. Steroid-induced glaucoma, a common type of secondary glaucoma, is also associated with elevated IOP (steroid-induced ocular hypertension (SIOH)). SIOH and glaucoma are currently treated with antiglaucoma agents, which often have suboptimal efficacy and are associated with adverse effects. The objective of this study was to determine if topical application of transresveratrol reduces IOP in rats with SIOH and to investigate its mechanisms of action. This study was divided into in vivo and in vitro studies. In the in vivo study, we evaluated the oculohypotensive effects of topical transresveratrol in normal and SIOH rats and investigated the role of adenosine receptors (ARs) and transforming growth factor-β (TGF-β) signalling in the IOP lowering effect of trans-resveratrol. Involvement of AR was studied by observing the IOP changes in response to trans-resveratrol after pretreating SIOH animals with AR subtype-specific antagonists. The study also investigated phospholipase C (PLC) activation, extracellular regulated kinase 1/2 (ERK1/2) phosphorylation and increased matrix metalloproteinases (MMPs) secretion in the aqueous humour (AH) as mechanism of resveratrolinduced oculohypotension in SIOH rats. In vitro studies evaluated the effect of trans-resveratrol on cellular signalling pathways of ARs and TGF-β in primary human trabecular meshwork cells (HTMCs)…
format Book Section
author Razali, Norhafiza
author_facet Razali, Norhafiza
author_sort Razali, Norhafiza
title Cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / Norhafiza Razali
title_short Cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / Norhafiza Razali
title_full Cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / Norhafiza Razali
title_fullStr Cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / Norhafiza Razali
title_full_unstemmed Cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / Norhafiza Razali
title_sort cellular mechanisms of action of resveratrol in regulation of aqueous humour dynamics / norhafiza razali
publisher Institute of Graduate Studies, UiTM
publishDate 2017
url http://ir.uitm.edu.my/id/eprint/19794/1/ABS_NORHAFIZA%20RAZALI%20TDRA%20VOL%2011%20IGS%2017.pdf
http://ir.uitm.edu.my/id/eprint/19794/
_version_ 1685649259749179392
score 13.211869

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