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Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah

The study investigated the aerosolization and inhalation profiles of rifampicin-oleic acid first generation liquid and solid nanoemulsions and their respective chitosan- and chitosan-folate conjugate-decorated second and third generation nanoemulsions. The liquid nanoemulsions were prepared by spont...

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Main Author: Shah, Kifayat Ullah
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2017
Subjects:
Malaysia
Online Access:http://ir.uitm.edu.my/id/eprint/19764/1/ABS_KIFAYAT%20ULLAH%20SHAH%20TDRA%20VOL%2011%20IGS%2017.pdf
http://ir.uitm.edu.my/id/eprint/19764/
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spelling my.uitm.ir.197642018-06-07T07:19:15Z http://ir.uitm.edu.my/id/eprint/19764/ Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah Shah, Kifayat Ullah Malaysia The study investigated the aerosolization and inhalation profiles of rifampicin-oleic acid first generation liquid and solid nanoemulsions and their respective chitosan- and chitosan-folate conjugate-decorated second and third generation nanoemulsions. The liquid nanoemulsions were prepared by spontaneous emulsification method and had their size, zeta potential, polydispersity index, morphology, pH, viscosity, surface tension, density, refractive index, drug content, drug release, aerosolization and inhalation profiles characterized. The first, second and third generation nanoemulsions had average droplet sizes of 43.89 ± 0.36 nm, 52.12 ± 0.36 nm and 59.69 ± 0.26 nm, with narrow polydispersity indices at 0.16 ± 0.03, 0.25 ± 0.03 and 0.23 ± 0.01 respectively. They exhibited desirable pH, surface tension, viscosity, refractive index, density, and viscosity attributes for pulmonary rifampicin administration. The second generation nanoemulsion was characterized by relatively low levels of burst drug release due to intimate chitosan packing at the oil globules’ surfaces and viscosifying effect on continuous phase, which was unattainable by the branched folate conjugate of chitosan. All nanoemulsions demonstrated more than 95 % aerosol output and inhalation efficiency greater than 75 % when delivered by nebulization. The aerosol output, aerosolized and inhaled fine particle fractions were primarily governed by the size and surface tension of nanoemulsions in an inverse relationship. The first, second and third generation nanoemulsions were converted to their corresponding solid counterparts by spray drying method… Institute of Graduate Studies, UiTM 2017 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19764/1/ABS_KIFAYAT%20ULLAH%20SHAH%20TDRA%20VOL%2011%20IGS%2017.pdf Shah, Kifayat Ullah (2017) Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah. In: The Doctoral Research Abstracts. IGS Biannual Publication, 11 (11). Institute of Graduate Studies, UiTM, Shah Alam.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Malaysia
spellingShingle Malaysia
Shah, Kifayat Ullah
Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
description The study investigated the aerosolization and inhalation profiles of rifampicin-oleic acid first generation liquid and solid nanoemulsions and their respective chitosan- and chitosan-folate conjugate-decorated second and third generation nanoemulsions. The liquid nanoemulsions were prepared by spontaneous emulsification method and had their size, zeta potential, polydispersity index, morphology, pH, viscosity, surface tension, density, refractive index, drug content, drug release, aerosolization and inhalation profiles characterized. The first, second and third generation nanoemulsions had average droplet sizes of 43.89 ± 0.36 nm, 52.12 ± 0.36 nm and 59.69 ± 0.26 nm, with narrow polydispersity indices at 0.16 ± 0.03, 0.25 ± 0.03 and 0.23 ± 0.01 respectively. They exhibited desirable pH, surface tension, viscosity, refractive index, density, and viscosity attributes for pulmonary rifampicin administration. The second generation nanoemulsion was characterized by relatively low levels of burst drug release due to intimate chitosan packing at the oil globules’ surfaces and viscosifying effect on continuous phase, which was unattainable by the branched folate conjugate of chitosan. All nanoemulsions demonstrated more than 95 % aerosol output and inhalation efficiency greater than 75 % when delivered by nebulization. The aerosol output, aerosolized and inhaled fine particle fractions were primarily governed by the size and surface tension of nanoemulsions in an inverse relationship. The first, second and third generation nanoemulsions were converted to their corresponding solid counterparts by spray drying method…
format Book Section
author Shah, Kifayat Ullah
author_facet Shah, Kifayat Ullah
author_sort Shah, Kifayat Ullah
title Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_short Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_full Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_fullStr Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_full_unstemmed Liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / Kifayat Ullah Shah
title_sort liquid and spray-dried nanoemulsion designs for pulmonary delivery of rifampicin / kifayat ullah shah
publisher Institute of Graduate Studies, UiTM
publishDate 2017
url http://ir.uitm.edu.my/id/eprint/19764/1/ABS_KIFAYAT%20ULLAH%20SHAH%20TDRA%20VOL%2011%20IGS%2017.pdf
http://ir.uitm.edu.my/id/eprint/19764/
_version_ 1685649255930265600
score 13.211869

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