Colon-specific delivery of 5-fluorouracil from zinc pectinate spheroids through in situ intra-capsular ethylcellulose- pectin plug formation / Assad Ali Faraj Elyagoby
Conventional fluid-bed and immersion film coating of hydrophilic zinc pectinate spheroids using ethylcellulose-pectin mixture is met with fast drug release due to hydrophobic ethylcellulose coat detachment. This study explored in situ intra-capsular spheroid coating for colon-specific delivery of 5-...
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| Main Author: | |
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| Format: | Book Section |
| Language: | English |
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Institute of Graduate Studies, UiTM
2014
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| Online Access: | http://ir.uitm.edu.my/id/eprint/19620/1/ABS_ASSAD%20ALI%20FARAJ%20ELYAGOBY%20TDRA%20VOL%206%20IGS_14.pdf http://ir.uitm.edu.my/id/eprint/19620/ |
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| Summary: | Conventional fluid-bed and immersion film coating of hydrophilic zinc pectinate spheroids using ethylcellulose-pectin mixture is met with fast drug release due to hydrophobic ethylcellulose coat detachment. This study explored in situ intra-capsular spheroid coating for colon-specific delivery of 5-fluorouracil. The solid coating powder was constituted of ethylcellulose and pectin in weight ratios of 11:0 to 2:9. Its weight ratio to spheroids was varied between 2:3 and 3:2. Delayed 5-fluorouracil release was obtained when the weight ratio of ethylcellulose and pectin in coating powder was kept at 8:3, and weight ratio of solid coating powder to spheroids was kept at 3:2 with particle size of ethylcellulose reduced to 22 μm. |
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