Cover Image

Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James

Alzheimer’s disease (AD) is the most common form of dementia. Until recently, AD is managed by relieving the cognitive symptoms without addressing one of the purportedly fundamental causes of the disease which is the formation of the amyloid plaques. The deposition and aggregation of β-amyloid are k...

Full description

Saved in:
Bibliographic Details
Main Author: James, Richard Muhammad Johari
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2014
Subjects:
Malaysia
RC Internal Medicine
Online Access:http://ir.uitm.edu.my/id/eprint/19246/1/ABS_RICHARD%20MUHAMMAD%20JOHARI%20JAMES%20TDRA%20VOL%205%20IGS_14.pdf
http://ir.uitm.edu.my/id/eprint/19246/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.uitm.ir.19246
record_format eprints
spelling my.uitm.ir.192462018-06-12T07:18:04Z http://ir.uitm.edu.my/id/eprint/19246/ Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James James, Richard Muhammad Johari Malaysia RC Internal Medicine Alzheimer’s disease (AD) is the most common form of dementia. Until recently, AD is managed by relieving the cognitive symptoms without addressing one of the purportedly fundamental causes of the disease which is the formation of the amyloid plaques. The deposition and aggregation of β-amyloid are key events in the onset, progression and pathogenesis of AD. Thus one of the emerging strategies in treating AD is to inhibit the enzyme responsible for the formation of amyloid plaques, which is β-site amyloid cleaving enzyme (BACE-1). Endophytes are currently viewed as an outstanding source of bioactive natural products and may provide BACE-1 inhibitors as potential drug candidates for the treatment of AD. A novel bioactive compound, F70HAB16 was successfully isolated from a local endophytic strain and was found to inhibit the BACE-1 enzyme in vitro (IC50=13 μM). Oral treatment with 5 mg/kg of F70HAB16 for 14 days in scopolamine-induced memory deficit mice model was found to restore memory impairment caused by scopolamine in the radial arm maze and Morris water maze (MWM) tasks. Institute of Graduate Studies, UiTM 2014 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19246/1/ABS_RICHARD%20MUHAMMAD%20JOHARI%20JAMES%20TDRA%20VOL%205%20IGS_14.pdf James, Richard Muhammad Johari (2014) Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 5 (5). Institute of Graduate Studies, UiTM, Shah Alam.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Malaysia
RC Internal Medicine
spellingShingle Malaysia
RC Internal Medicine
James, Richard Muhammad Johari
Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
description Alzheimer’s disease (AD) is the most common form of dementia. Until recently, AD is managed by relieving the cognitive symptoms without addressing one of the purportedly fundamental causes of the disease which is the formation of the amyloid plaques. The deposition and aggregation of β-amyloid are key events in the onset, progression and pathogenesis of AD. Thus one of the emerging strategies in treating AD is to inhibit the enzyme responsible for the formation of amyloid plaques, which is β-site amyloid cleaving enzyme (BACE-1). Endophytes are currently viewed as an outstanding source of bioactive natural products and may provide BACE-1 inhibitors as potential drug candidates for the treatment of AD. A novel bioactive compound, F70HAB16 was successfully isolated from a local endophytic strain and was found to inhibit the BACE-1 enzyme in vitro (IC50=13 μM). Oral treatment with 5 mg/kg of F70HAB16 for 14 days in scopolamine-induced memory deficit mice model was found to restore memory impairment caused by scopolamine in the radial arm maze and Morris water maze (MWM) tasks.
format Book Section
author James, Richard Muhammad Johari
author_facet James, Richard Muhammad Johari
author_sort James, Richard Muhammad Johari
title Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_short Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_full Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_fullStr Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_full_unstemmed Modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (F70hab16) from Malaysian Endophyte Cytospora Rhizophorae, in murine models for alzheimer’s disease / Richard Muhammad Johari James
title_sort modulation of the amyloidogenic pathway by a novel β-secretase inhibitor (f70hab16) from malaysian endophyte cytospora rhizophorae, in murine models for alzheimer’s disease / richard muhammad johari james
publisher Institute of Graduate Studies, UiTM
publishDate 2014
url http://ir.uitm.edu.my/id/eprint/19246/1/ABS_RICHARD%20MUHAMMAD%20JOHARI%20JAMES%20TDRA%20VOL%205%20IGS_14.pdf
http://ir.uitm.edu.my/id/eprint/19246/
_version_ 1685649187303063552
score 13.239859

Similar Items