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Biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / Fathi Farag Mughrabi

The present study was performed to evaluate the acute toxicity, anti-ulcer, wound healing, antioxidant and antibacterial activities of a Schiff base namely benzyl N’-(indol-3-ylmethylidene)-hydrazinecarbodithioate (BIHC) and its metal complexes, BIHCZn and BIHCNi. The three compounds namely BIH...

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Main Author: Mughrabi, Fathi Farag
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2012
Subjects:
Malaysia
Online Access:http://ir.uitm.edu.my/id/eprint/19062/1/ABS_FATHI%20FARAG%20MUGHRABI%20TDRA%20VOL%201%20IGS%2012.pdf
http://ir.uitm.edu.my/id/eprint/19062/
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spelling my.uitm.ir.190622018-06-08T01:17:14Z http://ir.uitm.edu.my/id/eprint/19062/ Biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / Fathi Farag Mughrabi Mughrabi, Fathi Farag Malaysia The present study was performed to evaluate the acute toxicity, anti-ulcer, wound healing, antioxidant and antibacterial activities of a Schiff base namely benzyl N’-(indol-3-ylmethylidene)-hydrazinecarbodithioate (BIHC) and its metal complexes, BIHCZn and BIHCNi. The three compounds namely BIHC, BIHCZn and BIHCNi are subsequently collectively referred to as BIHCD. Acute and subchronic toxicity investigation of BIHCD did not show any signs or symptoms of toxicity and all animals remained alive. Blood biochemistry, hematology, and histopathology analysis did not show any significant differences between control and treated groups. BIHCD appears to be safe and no drug-related toxicity was detected even at the highest dose investigated (400mg/kg). Antiulcer activity of BIHCD against ethanol-induced gastric ulcer was studied. Gastric juice was collected for the determination of pH and mucous weight. Grossly, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either derivative compounds or Omeprazole resulted in significant protection of gastric mucosal injury. Flattening of gastric mucosal folds was also observed in rats pretreated with BIHCD. Histological studies of the gastric wall of ulcer control group revealed severe damage of gastric mucosa, along with oedema and leucocytes infiltration of the submucosal layer compared to rats pre-treated with either BIHCD or Omeprazole where there were marked gastric protection along with the reduction or absence of oedema and leucocytes infiltration of the submucosal layer. BIHCD and its derivatives promote ulcer protection as ascertained by the comparative decreases in ulcer areas, reduction of oedema and leucocytes infiltration of the submucosal layer. Topical application of BIHC and its metal complexes on the wounds in normal and diabetic rats showed that wound dressed with BIHCD healed significantly earlier than those treated with 10% Tween 20. Institute of Graduate Studies, UiTM 2012 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19062/1/ABS_FATHI%20FARAG%20MUGHRABI%20TDRA%20VOL%201%20IGS%2012.pdf Mughrabi, Fathi Farag (2012) Biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / Fathi Farag Mughrabi. In: The Doctoral Research Abstracts. IPSis Biannual Publication, 1 (1). Institute of Graduate Studies, UiTM, Shah Alam.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Malaysia
spellingShingle Malaysia
Mughrabi, Fathi Farag
Biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / Fathi Farag Mughrabi
description The present study was performed to evaluate the acute toxicity, anti-ulcer, wound healing, antioxidant and antibacterial activities of a Schiff base namely benzyl N’-(indol-3-ylmethylidene)-hydrazinecarbodithioate (BIHC) and its metal complexes, BIHCZn and BIHCNi. The three compounds namely BIHC, BIHCZn and BIHCNi are subsequently collectively referred to as BIHCD. Acute and subchronic toxicity investigation of BIHCD did not show any signs or symptoms of toxicity and all animals remained alive. Blood biochemistry, hematology, and histopathology analysis did not show any significant differences between control and treated groups. BIHCD appears to be safe and no drug-related toxicity was detected even at the highest dose investigated (400mg/kg). Antiulcer activity of BIHCD against ethanol-induced gastric ulcer was studied. Gastric juice was collected for the determination of pH and mucous weight. Grossly, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either derivative compounds or Omeprazole resulted in significant protection of gastric mucosal injury. Flattening of gastric mucosal folds was also observed in rats pretreated with BIHCD. Histological studies of the gastric wall of ulcer control group revealed severe damage of gastric mucosa, along with oedema and leucocytes infiltration of the submucosal layer compared to rats pre-treated with either BIHCD or Omeprazole where there were marked gastric protection along with the reduction or absence of oedema and leucocytes infiltration of the submucosal layer. BIHCD and its derivatives promote ulcer protection as ascertained by the comparative decreases in ulcer areas, reduction of oedema and leucocytes infiltration of the submucosal layer. Topical application of BIHC and its metal complexes on the wounds in normal and diabetic rats showed that wound dressed with BIHCD healed significantly earlier than those treated with 10% Tween 20.
format Book Section
author Mughrabi, Fathi Farag
author_facet Mughrabi, Fathi Farag
author_sort Mughrabi, Fathi Farag
title Biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / Fathi Farag Mughrabi
title_short Biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / Fathi Farag Mughrabi
title_full Biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / Fathi Farag Mughrabi
title_fullStr Biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / Fathi Farag Mughrabi
title_full_unstemmed Biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / Fathi Farag Mughrabi
title_sort biological activities of dithiocarbazate schiff base derivatives on normal and diabetic rats / fathi farag mughrabi
publisher Institute of Graduate Studies, UiTM
publishDate 2012
url http://ir.uitm.edu.my/id/eprint/19062/1/ABS_FATHI%20FARAG%20MUGHRABI%20TDRA%20VOL%201%20IGS%2012.pdf
http://ir.uitm.edu.my/id/eprint/19062/
_version_ 1685649162259922944
score 13.211869

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