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Treatment of dermatophytoses by film-forming topical antifungal spray / Mohd Faiz Mustaffa

Dermatophytosis is a major public health problem especially in tropical countries like Malaysia. Several studies report incidence of resistance to common treatment for dermatophytosis with drugs such as terbinafine, fluconazole, and griseofulvin. Resistance arise as consequence of non-adherence with...

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Main Author: Mustaffa, Mohd Faiz
Format: Thesis
Language:English
Published: 2016
Online Access:https://ir.uitm.edu.my/id/eprint/17783/2/TM_MOHD%20FAIZ%20MUSTAFFA%20PH%2016_5.pdf
https://ir.uitm.edu.my/id/eprint/17783/
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spelling my.uitm.ir.177832022-04-14T02:19:25Z https://ir.uitm.edu.my/id/eprint/17783/ Treatment of dermatophytoses by film-forming topical antifungal spray / Mohd Faiz Mustaffa Mustaffa, Mohd Faiz Dermatophytosis is a major public health problem especially in tropical countries like Malaysia. Several studies report incidence of resistance to common treatment for dermatophytosis with drugs such as terbinafine, fluconazole, and griseofulvin. Resistance arise as consequence of non-adherence with prescribed treatment regimens, repetitive use of antifungal drugs more than once in a patient's life, incidence of reabsorption or washout of drug from the skin and failure of drug to reach the stratum corneum. Currently available antifungal preparations (ointments or creams) are easily removed after application and may contribute to none cure and/or to development of resistance. This project was initiated with the intention of producing an antifungal topical drug delivery system using film-forming polymeric solutions. The research was divided into 4 main areas which are (1) preliminary studies to test antimicrobial activities and determine the cytotoxicity of selected antimicrobial drugs and natural product extracts in vitro, (2) formulation and characterization of film-forming solutions, (3) elucidate skin permeation of selected drug, (4) determine antifungal activity and safety profile of topical film forming polymeric spray. Seventy-three (73) formulations were prepared but only 6 formulations were chosen from the preformulation studies were further testing. Formulation A was superior to the other tested formulations due dries in less than 1 minute, is non-sticky and forms a transparent film on the skin. 2016-03 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/17783/2/TM_MOHD%20FAIZ%20MUSTAFFA%20PH%2016_5.pdf (2016) Treatment of dermatophytoses by film-forming topical antifungal spray / Mohd Faiz Mustaffa. Masters thesis, thesis, Universiti Teknologi MARA.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
description Dermatophytosis is a major public health problem especially in tropical countries like Malaysia. Several studies report incidence of resistance to common treatment for dermatophytosis with drugs such as terbinafine, fluconazole, and griseofulvin. Resistance arise as consequence of non-adherence with prescribed treatment regimens, repetitive use of antifungal drugs more than once in a patient's life, incidence of reabsorption or washout of drug from the skin and failure of drug to reach the stratum corneum. Currently available antifungal preparations (ointments or creams) are easily removed after application and may contribute to none cure and/or to development of resistance. This project was initiated with the intention of producing an antifungal topical drug delivery system using film-forming polymeric solutions. The research was divided into 4 main areas which are (1) preliminary studies to test antimicrobial activities and determine the cytotoxicity of selected antimicrobial drugs and natural product extracts in vitro, (2) formulation and characterization of film-forming solutions, (3) elucidate skin permeation of selected drug, (4) determine antifungal activity and safety profile of topical film forming polymeric spray. Seventy-three (73) formulations were prepared but only 6 formulations were chosen from the preformulation studies were further testing. Formulation A was superior to the other tested formulations due dries in less than 1 minute, is non-sticky and forms a transparent film on the skin.
format Thesis
author Mustaffa, Mohd Faiz
spellingShingle Mustaffa, Mohd Faiz
Treatment of dermatophytoses by film-forming topical antifungal spray / Mohd Faiz Mustaffa
author_facet Mustaffa, Mohd Faiz
author_sort Mustaffa, Mohd Faiz
title Treatment of dermatophytoses by film-forming topical antifungal spray / Mohd Faiz Mustaffa
title_short Treatment of dermatophytoses by film-forming topical antifungal spray / Mohd Faiz Mustaffa
title_full Treatment of dermatophytoses by film-forming topical antifungal spray / Mohd Faiz Mustaffa
title_fullStr Treatment of dermatophytoses by film-forming topical antifungal spray / Mohd Faiz Mustaffa
title_full_unstemmed Treatment of dermatophytoses by film-forming topical antifungal spray / Mohd Faiz Mustaffa
title_sort treatment of dermatophytoses by film-forming topical antifungal spray / mohd faiz mustaffa
publishDate 2016
url https://ir.uitm.edu.my/id/eprint/17783/2/TM_MOHD%20FAIZ%20MUSTAFFA%20PH%2016_5.pdf
https://ir.uitm.edu.my/id/eprint/17783/
_version_ 1731229056646512640
score 13.211869

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