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The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf

Chronic stress has been identified as the major pathophysiological etiology for numerous of diseases. One of the underlying detrimental mechanism induced by stress is caused by oxidative stress. The redox imbalanced due to oxidative stress is found to be reversible by the action of antioxidant. The...

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Main Author: Abdul Manaf, Mohd Hadzrul Hisham
Format: Thesis
Language:English
Published: 2016
Subjects:
RB Pathology
TP Chemical technology
Online Access:https://ir.uitm.edu.my/id/eprint/17768/2/17768.pdf
https://ir.uitm.edu.my/id/eprint/17768/
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spelling my.uitm.ir.177682022-11-22T04:39:04Z https://ir.uitm.edu.my/id/eprint/17768/ The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf Abdul Manaf, Mohd Hadzrul Hisham RB Pathology TP Chemical technology Chronic stress has been identified as the major pathophysiological etiology for numerous of diseases. One of the underlying detrimental mechanism induced by stress is caused by oxidative stress. The redox imbalanced due to oxidative stress is found to be reversible by the action of antioxidant. The present study focused on the effect of Cosmos caudatus (C. caudatus) towards biological stress markers. Male Sprague-Dawley rats were randomly divided into 5 groups, treated with methanolic extract of C. caudatus leaves (100 & 200 mg/kg), quercetin (100 & 200 mg/kg) and saline (control) respectively for 21 days prior and throughout the 13 days of experiment. The rats were then subjected to forced swimming stress and bloods were withdrawn at 6 different days (Basal, Day 1 and every 2 days continuously). The blood analysis revealed that treatment with C. caudatus able to reduce plasma corticosterone level significantly (p<0.005) compared to the control group, reduced plasma malondialdehyde level (p<0.005) and increased plasma total antioxidant capacity level (p<0.005) in the rats following stress exposure. C. caudatus was also found to have a preservation effect on the plasma dehydroepiandrosterone-sulphate level by inhibiting the fluctuation (increment and reduction) in its level following stress exposure. Based on these observations, it is concluded that C. caudatus act as an anti-stress agent through the action of antioxidant activities in modulating stress response mechanisms and serve as a protective agent towards the pathological effect induced by stress. 2016 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/17768/2/17768.pdf The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf. (2016) Masters thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/17768.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic RB Pathology
TP Chemical technology
spellingShingle RB Pathology
TP Chemical technology
Abdul Manaf, Mohd Hadzrul Hisham
The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
description Chronic stress has been identified as the major pathophysiological etiology for numerous of diseases. One of the underlying detrimental mechanism induced by stress is caused by oxidative stress. The redox imbalanced due to oxidative stress is found to be reversible by the action of antioxidant. The present study focused on the effect of Cosmos caudatus (C. caudatus) towards biological stress markers. Male Sprague-Dawley rats were randomly divided into 5 groups, treated with methanolic extract of C. caudatus leaves (100 & 200 mg/kg), quercetin (100 & 200 mg/kg) and saline (control) respectively for 21 days prior and throughout the 13 days of experiment. The rats were then subjected to forced swimming stress and bloods were withdrawn at 6 different days (Basal, Day 1 and every 2 days continuously). The blood analysis revealed that treatment with C. caudatus able to reduce plasma corticosterone level significantly (p<0.005) compared to the control group, reduced plasma malondialdehyde level (p<0.005) and increased plasma total antioxidant capacity level (p<0.005) in the rats following stress exposure. C. caudatus was also found to have a preservation effect on the plasma dehydroepiandrosterone-sulphate level by inhibiting the fluctuation (increment and reduction) in its level following stress exposure. Based on these observations, it is concluded that C. caudatus act as an anti-stress agent through the action of antioxidant activities in modulating stress response mechanisms and serve as a protective agent towards the pathological effect induced by stress.
format Thesis
author Abdul Manaf, Mohd Hadzrul Hisham
author_facet Abdul Manaf, Mohd Hadzrul Hisham
author_sort Abdul Manaf, Mohd Hadzrul Hisham
title The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_short The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_full The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_fullStr The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_full_unstemmed The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_sort effect of cosmos caudatus on chronic repetitive forced swimming stress / mohd hadzrul hisham abdul manaf
publishDate 2016
url https://ir.uitm.edu.my/id/eprint/17768/2/17768.pdf
https://ir.uitm.edu.my/id/eprint/17768/
_version_ 1751539766002712576
score 13.211869

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