Cover Image

The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa

In the present study, the cardiovascular effect of Tinospora crispa extracts on the isolated paced left atrium, spontaneously beating right atrium and the descending aorta of rats were studied. The stems of T.crispa were serially extracted with petroleum ether, followed by chloroform, methanol and l...

Full description

Saved in:
Bibliographic Details
Main Authors: Bakhari, Nor Aziyah, Isa, Norain
Format: Article
Language:English
Published: Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) 2010
Online Access:http://ir.uitm.edu.my/id/eprint/16497/1/AJ_NOR%20AZIYAH%20BAKHARI%20ESTEEM%2010.pdf
http://ir.uitm.edu.my/id/eprint/16497/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.uitm.ir.16497
record_format eprints
spelling my.uitm.ir.164972019-11-18T07:33:05Z http://ir.uitm.edu.my/id/eprint/16497/ The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa Bakhari, Nor Aziyah Isa, Norain In the present study, the cardiovascular effect of Tinospora crispa extracts on the isolated paced left atrium, spontaneously beating right atrium and the descending aorta of rats were studied. The stems of T.crispa were serially extracted with petroleum ether, followed by chloroform, methanol and lastly water. The chloroform extract caused the strongest inhibition on the inotropic effect of isoprenaline (ISP) to the left atrium. The inhibition was non-competetive since the maximum of the log dose-response curve of the atrium to ISP was reduced. However, none of the extracts (0.2-1.0 mg/mL) significantly influenced the inotropic activity of the right atrium to ISP All the extracts studied also non-competetively inhibited the noradrenaline (NA)-induced rat aortic strips contraction and the chloroform extract was again found to be the most potent extract. The chloroform extract was therefore fractionated and the effect of the fractions on the NA-induced rat aortic strips contraction was examined. CF3 fraction was found to be the most active fraction and was further fractionated. The fractions were tested again on the NA-induced rat aortic strips contraction. However, all fractions showed almost the same effect where 0.50 mg/mL fractions reduced the maximum response by about 60-80%. Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) 2010 Article PeerReviewed text en http://ir.uitm.edu.my/id/eprint/16497/1/AJ_NOR%20AZIYAH%20BAKHARI%20ESTEEM%2010.pdf Bakhari, Nor Aziyah and Isa, Norain (2010) The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa. Esteem Academic Journal, 6 (2). pp. 141-150. ISSN 1675-7939
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
description In the present study, the cardiovascular effect of Tinospora crispa extracts on the isolated paced left atrium, spontaneously beating right atrium and the descending aorta of rats were studied. The stems of T.crispa were serially extracted with petroleum ether, followed by chloroform, methanol and lastly water. The chloroform extract caused the strongest inhibition on the inotropic effect of isoprenaline (ISP) to the left atrium. The inhibition was non-competetive since the maximum of the log dose-response curve of the atrium to ISP was reduced. However, none of the extracts (0.2-1.0 mg/mL) significantly influenced the inotropic activity of the right atrium to ISP All the extracts studied also non-competetively inhibited the noradrenaline (NA)-induced rat aortic strips contraction and the chloroform extract was again found to be the most potent extract. The chloroform extract was therefore fractionated and the effect of the fractions on the NA-induced rat aortic strips contraction was examined. CF3 fraction was found to be the most active fraction and was further fractionated. The fractions were tested again on the NA-induced rat aortic strips contraction. However, all fractions showed almost the same effect where 0.50 mg/mL fractions reduced the maximum response by about 60-80%.
format Article
author Bakhari, Nor Aziyah
Isa, Norain
spellingShingle Bakhari, Nor Aziyah
Isa, Norain
The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa
author_facet Bakhari, Nor Aziyah
Isa, Norain
author_sort Bakhari, Nor Aziyah
title The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa
title_short The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa
title_full The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa
title_fullStr The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa
title_full_unstemmed The effect of Tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / Nor Aziyah Bakhari and Norain Isa
title_sort effect of tinospora crispa extracts on the contraction of isolated atrium and aorta of rats / nor aziyah bakhari and norain isa
publisher Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA)
publishDate 2010
url http://ir.uitm.edu.my/id/eprint/16497/1/AJ_NOR%20AZIYAH%20BAKHARI%20ESTEEM%2010.pdf
http://ir.uitm.edu.my/id/eprint/16497/
_version_ 1685648810574872576
score 13.211869

Similar Items