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Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri

Shorea macroptera from family Dipterocarpaceae was studied for its phytochemical and biological activities. Eight compounds have been isolated including two compounds in mixture which consists of nine resveratrol oligomers and an isoferrulic derivative. The compounds were identified as (^-pentacosyl...

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Main Author: Mohd Nazri, Nur Ainaa Atikah
Format: Thesis
Language:English
Published: 2014
Online Access:https://ir.uitm.edu.my/id/eprint/16397/1/TM_NUR%20AINAA%20ATIKAH%20MOHD%20NAZRI%20AS%2014_5.pdf
https://ir.uitm.edu.my/id/eprint/16397/
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spelling my.uitm.ir.163972022-03-23T02:45:17Z https://ir.uitm.edu.my/id/eprint/16397/ Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri Mohd Nazri, Nur Ainaa Atikah Shorea macroptera from family Dipterocarpaceae was studied for its phytochemical and biological activities. Eight compounds have been isolated including two compounds in mixture which consists of nine resveratrol oligomers and an isoferrulic derivative. The compounds were identified as (^-pentacosyl 3-(3-hydroxy-4-methoxyphenyl) acrylate, E-viniferin, davidiol A, hemsleyanol D, hopeaphenol A, hopeaphenol, isohopeaphenol, stenophyllol B, gnetol and laevifonol. Gnetol is a monomer resveratrol, £- viniferin and laevifonol are dimer resveratrols, davidiol A and stenophyllol B are trimer resveratrols while hemsleyanol D, hopeaphenol A, hopeaphenol and isohopeaphenol are tetramer resveratrols. Structural elucidation was performed with the aid of spectroscopic methods such as ultraviolet (UV), infrared (IR), mass spectrometry (MS), ID and 2D nuclear magnetic resonance (NMR). Shorea macroptera extract and some of the isolated compounds have been tested for antioxidant, antibacterial and also cytotoxic activities. Shorea macroptera extract showed good antioxidant and antibacterial activities compared to individual isolated compounds, e-viniferin demonstrated marked cytotoxic activity which strongly inhibited HL-60 cell lines but moderately on HeLa cell lines. Davidiol A showed significant cytotoxic activities. It strongly inhibited HL-60 cell lines but moderately inhibited HeLa cell line. Hemsleyanol D moderately inhibited the growth of HeLa cell line. Hopeaphenol displayed significant free radical scavenging activity. Stenophyllol B was found active in free radical scavenging and cytotoxic activities. Stenophyllol B exhibited moderate free radical activity and moderately inhibited HL-60 cell lines and HeLa cell lines. However, laevifonol was inactive towards all three assay tested. 2014 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/16397/1/TM_NUR%20AINAA%20ATIKAH%20MOHD%20NAZRI%20AS%2014_5.pdf (2014) Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri. Masters thesis, thesis, Universiti Teknologi MARA.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
description Shorea macroptera from family Dipterocarpaceae was studied for its phytochemical and biological activities. Eight compounds have been isolated including two compounds in mixture which consists of nine resveratrol oligomers and an isoferrulic derivative. The compounds were identified as (^-pentacosyl 3-(3-hydroxy-4-methoxyphenyl) acrylate, E-viniferin, davidiol A, hemsleyanol D, hopeaphenol A, hopeaphenol, isohopeaphenol, stenophyllol B, gnetol and laevifonol. Gnetol is a monomer resveratrol, £- viniferin and laevifonol are dimer resveratrols, davidiol A and stenophyllol B are trimer resveratrols while hemsleyanol D, hopeaphenol A, hopeaphenol and isohopeaphenol are tetramer resveratrols. Structural elucidation was performed with the aid of spectroscopic methods such as ultraviolet (UV), infrared (IR), mass spectrometry (MS), ID and 2D nuclear magnetic resonance (NMR). Shorea macroptera extract and some of the isolated compounds have been tested for antioxidant, antibacterial and also cytotoxic activities. Shorea macroptera extract showed good antioxidant and antibacterial activities compared to individual isolated compounds, e-viniferin demonstrated marked cytotoxic activity which strongly inhibited HL-60 cell lines but moderately on HeLa cell lines. Davidiol A showed significant cytotoxic activities. It strongly inhibited HL-60 cell lines but moderately inhibited HeLa cell line. Hemsleyanol D moderately inhibited the growth of HeLa cell line. Hopeaphenol displayed significant free radical scavenging activity. Stenophyllol B was found active in free radical scavenging and cytotoxic activities. Stenophyllol B exhibited moderate free radical activity and moderately inhibited HL-60 cell lines and HeLa cell lines. However, laevifonol was inactive towards all three assay tested.
format Thesis
author Mohd Nazri, Nur Ainaa Atikah
spellingShingle Mohd Nazri, Nur Ainaa Atikah
Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
author_facet Mohd Nazri, Nur Ainaa Atikah
author_sort Mohd Nazri, Nur Ainaa Atikah
title Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_short Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_full Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_fullStr Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_full_unstemmed Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_sort phytochemical study and bio activity from the stem bark of shore a macroptera dyer / nur ainaa atikah mohd nazri
publishDate 2014
url https://ir.uitm.edu.my/id/eprint/16397/1/TM_NUR%20AINAA%20ATIKAH%20MOHD%20NAZRI%20AS%2014_5.pdf
https://ir.uitm.edu.my/id/eprint/16397/
_version_ 1729707437671317504
score 13.223943

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