Cover Image

Single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / Lua Pel Lin, Getrude Cosmas and Nurul Hudani Md. Nawi

The importance of health-related quality of life (HRQoL) assessment in epilepsy is justified by potential adverse drug reactions and disease-related psychosocial impacts. This study aims 1) to compare HRQoL outcomes between single and multiple drug regimen and 2) to determine the correlation of HRQo...

Full description

Saved in:
Bibliographic Details
Main Authors: Lua, Pel Lin, Getrude, Cosmas, Md. Nawi, Nurul Hudani
Format: Article
Language:English
Published: Institute of Quality and Knowledge Advancement (InQKA) and University Publication Centre (UPENA) 2007
Subjects:
Quality of life
Online Access:http://ir.uitm.edu.my/id/eprint/16186/1/AJ_LUA%20PEI%20LIN%20MJQ%2007.pdf
http://ir.uitm.edu.my/id/eprint/16186/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.uitm.ir.16186
record_format eprints
spelling my.uitm.ir.161862017-03-08T07:39:43Z http://ir.uitm.edu.my/id/eprint/16186/ Single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / Lua Pel Lin, Getrude Cosmas and Nurul Hudani Md. Nawi Lua, Pel Lin Getrude, Cosmas Md. Nawi, Nurul Hudani Quality of life The importance of health-related quality of life (HRQoL) assessment in epilepsy is justified by potential adverse drug reactions and disease-related psychosocial impacts. This study aims 1) to compare HRQoL outcomes between single and multiple drug regimen and 2) to determine the correlation of HRQoL domain and Total QoL Score. Twenty-two out of 30 eligible out-patients were recruited from a Malaysian public hospital (response rate = 73.3.%). Following written consents, the Malay Quality of Life In Epilepsy -31 (QOLIE-31) instrument was administered (domains: Seizure Worry, Overall Qol, Emotional Well-Being, Energy/Fatigue, Cognitive Functioning, Medication Effects and Social Functioning). Respondents ranged from 18-49 years (mean age= 30; male=9; unmarried-16, jobless = 12). The most commonly-prescribed epilepsy medications were carbamazepine (n=14), sodium valproate (n=ll) and lamotrigine (n=7). Nine participants were on a single drug (Group A) while 11 patients were prescribed > 1 drug (Group B) (missing=2). Results showed that Group A patients produced better scores in all HRQoL domains (except Seizure Worry and Social Functioning) compared to Group B (significant for Emotional Well- Being; p=0.041). The Cognitive Functioning domain correlated ignificantly strongest with Total QoL Score (rs = 0.844). These outcomes indicate that prescribing multiple drugs for epilepsy do not necessarily improve HRQoL and patients strongly associated their cognitive functioning to total QoL. Such information would enhance healthcare professionals' awareness towards HRQoL and could guide prescribing pattern for epilepsy drugs. Nevertheless, other confounding variables required consideration and a larger sample size is needed to generate a more concrete conclusion in future. Institute of Quality and Knowledge Advancement (InQKA) and University Publication Centre (UPENA) 2007 Article PeerReviewed text en http://ir.uitm.edu.my/id/eprint/16186/1/AJ_LUA%20PEI%20LIN%20MJQ%2007.pdf Lua, Pel Lin and Getrude, Cosmas and Md. Nawi, Nurul Hudani (2007) Single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / Lua Pel Lin, Getrude Cosmas and Nurul Hudani Md. Nawi. Malaysian Journal of Quality, 2. pp. 93-105. ISSN 1823-7347
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Quality of life
spellingShingle Quality of life
Lua, Pel Lin
Getrude, Cosmas
Md. Nawi, Nurul Hudani
Single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / Lua Pel Lin, Getrude Cosmas and Nurul Hudani Md. Nawi
description The importance of health-related quality of life (HRQoL) assessment in epilepsy is justified by potential adverse drug reactions and disease-related psychosocial impacts. This study aims 1) to compare HRQoL outcomes between single and multiple drug regimen and 2) to determine the correlation of HRQoL domain and Total QoL Score. Twenty-two out of 30 eligible out-patients were recruited from a Malaysian public hospital (response rate = 73.3.%). Following written consents, the Malay Quality of Life In Epilepsy -31 (QOLIE-31) instrument was administered (domains: Seizure Worry, Overall Qol, Emotional Well-Being, Energy/Fatigue, Cognitive Functioning, Medication Effects and Social Functioning). Respondents ranged from 18-49 years (mean age= 30; male=9; unmarried-16, jobless = 12). The most commonly-prescribed epilepsy medications were carbamazepine (n=14), sodium valproate (n=ll) and lamotrigine (n=7). Nine participants were on a single drug (Group A) while 11 patients were prescribed > 1 drug (Group B) (missing=2). Results showed that Group A patients produced better scores in all HRQoL domains (except Seizure Worry and Social Functioning) compared to Group B (significant for Emotional Well- Being; p=0.041). The Cognitive Functioning domain correlated ignificantly strongest with Total QoL Score (rs = 0.844). These outcomes indicate that prescribing multiple drugs for epilepsy do not necessarily improve HRQoL and patients strongly associated their cognitive functioning to total QoL. Such information would enhance healthcare professionals' awareness towards HRQoL and could guide prescribing pattern for epilepsy drugs. Nevertheless, other confounding variables required consideration and a larger sample size is needed to generate a more concrete conclusion in future.
format Article
author Lua, Pel Lin
Getrude, Cosmas
Md. Nawi, Nurul Hudani
author_facet Lua, Pel Lin
Getrude, Cosmas
Md. Nawi, Nurul Hudani
author_sort Lua, Pel Lin
title Single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / Lua Pel Lin, Getrude Cosmas and Nurul Hudani Md. Nawi
title_short Single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / Lua Pel Lin, Getrude Cosmas and Nurul Hudani Md. Nawi
title_full Single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / Lua Pel Lin, Getrude Cosmas and Nurul Hudani Md. Nawi
title_fullStr Single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / Lua Pel Lin, Getrude Cosmas and Nurul Hudani Md. Nawi
title_full_unstemmed Single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / Lua Pel Lin, Getrude Cosmas and Nurul Hudani Md. Nawi
title_sort single versus multiple drug regimen in epilepsy management: assessment of health-related quality of life outcomes / lua pel lin, getrude cosmas and nurul hudani md. nawi
publisher Institute of Quality and Knowledge Advancement (InQKA) and University Publication Centre (UPENA)
publishDate 2007
url http://ir.uitm.edu.my/id/eprint/16186/1/AJ_LUA%20PEI%20LIN%20MJQ%2007.pdf
http://ir.uitm.edu.my/id/eprint/16186/
_version_ 1685648765646536704
score 13.211869

Similar Items