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Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh

Since the last decade, various formulation and processing approaches have been introduced in drug delivery system design to negate the propensity of drug release from dosage form in the acidic gastric region. Polysaccharides have been employed in the formulation of pharmaceutical drug delivery syste...

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Main Author: Mohd Salleh, Nurul Hidayah
Format: Thesis
Language:English
Published: 2015
Subjects:
Drugs prescribing
Drugs and their actions
Online Access:https://ir.uitm.edu.my/id/eprint/15671/1/TM_NURUL%20HIDAYAH%20MOHD%20SALLEH%20PH%2015_5.pdf
https://ir.uitm.edu.my/id/eprint/15671/
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spelling my.uitm.ir.156712022-03-03T08:54:35Z https://ir.uitm.edu.my/id/eprint/15671/ Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh Mohd Salleh, Nurul Hidayah Drugs prescribing Drugs and their actions Since the last decade, various formulation and processing approaches have been introduced in drug delivery system design to negate the propensity of drug release from dosage form in the acidic gastric region. Polysaccharides have been employed in the formulation of pharmaceutical drug delivery system for small molecule drug. Nevertheless, the formed matrix frequently is found to have a porous structure. Consequently, an uncontrollably fast release rate of small molecule drug is resulted. Such rate of drug release is undesirable in the case of the need to target the drugs to the lower part of gastrointestinal tract, particularly, the colon. Alginate is a type of polysaccharide that has been employed in the formulation of pharmaceutical drug delivery system for small molecule drug. It is produced from brown seaweeds, and is biocompatible, non-toxic, non-immunogenic and biodegradable. The present study investigates small molecule drug release from spheroids prepared from guluronic acidrich alginate. The drug release property of these spheroids was examined with reference to additive and microwave effects as formulation and processing variables respectively. The spheroids were prepared by extrusion-spheronization technique using microcrystalline cellulose as spheronization aid, zinc chloride as crosslinking agent, chlorpheniramine maleate as model water-soluble drug, stearic acid and 1 2 - hydroxystearic acid as additives. The formed spheroids were subjected to size, shape, drug content, drug release, zinc release, fourier transform infrared spectroscopy, differential scanning calorimetry and surface morphology analysis. They were treated by microwave at 80 W for 5 to 40 min when required. Alginate spheroids demonstrated a fast drug release characteristics and such fast release attribute can be reduced through zinc alginate crosslinkage formation. The zinc alginate spheroids exhibited a lower level of drug release despite the matrix was disintegrated into fines particles which had a larger specific surface area for drug dissolution. Loading of stearic acid or 1 2 -hydroxystearic acid into alginate or zinc alginate spheroids did not substantially retard drug release though these fatty acids were relatively hydrophobic. Overall, the treatment of alginate-based spheroids by microwave tended to bring minor changes in drug release property except that of zinc alginate-1 2 -hydroxystearic acid spheroids where O-H moiety of fatty acid and alginate responded to the influence of microwave. 2015 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/15671/1/TM_NURUL%20HIDAYAH%20MOHD%20SALLEH%20PH%2015_5.pdf ID15671 Mohd Salleh, Nurul Hidayah (2015) Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh. Masters thesis, thesis, Universiti Teknologi MARA.
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Drugs prescribing
Drugs and their actions
spellingShingle Drugs prescribing
Drugs and their actions
Mohd Salleh, Nurul Hidayah
Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh
description Since the last decade, various formulation and processing approaches have been introduced in drug delivery system design to negate the propensity of drug release from dosage form in the acidic gastric region. Polysaccharides have been employed in the formulation of pharmaceutical drug delivery system for small molecule drug. Nevertheless, the formed matrix frequently is found to have a porous structure. Consequently, an uncontrollably fast release rate of small molecule drug is resulted. Such rate of drug release is undesirable in the case of the need to target the drugs to the lower part of gastrointestinal tract, particularly, the colon. Alginate is a type of polysaccharide that has been employed in the formulation of pharmaceutical drug delivery system for small molecule drug. It is produced from brown seaweeds, and is biocompatible, non-toxic, non-immunogenic and biodegradable. The present study investigates small molecule drug release from spheroids prepared from guluronic acidrich alginate. The drug release property of these spheroids was examined with reference to additive and microwave effects as formulation and processing variables respectively. The spheroids were prepared by extrusion-spheronization technique using microcrystalline cellulose as spheronization aid, zinc chloride as crosslinking agent, chlorpheniramine maleate as model water-soluble drug, stearic acid and 1 2 - hydroxystearic acid as additives. The formed spheroids were subjected to size, shape, drug content, drug release, zinc release, fourier transform infrared spectroscopy, differential scanning calorimetry and surface morphology analysis. They were treated by microwave at 80 W for 5 to 40 min when required. Alginate spheroids demonstrated a fast drug release characteristics and such fast release attribute can be reduced through zinc alginate crosslinkage formation. The zinc alginate spheroids exhibited a lower level of drug release despite the matrix was disintegrated into fines particles which had a larger specific surface area for drug dissolution. Loading of stearic acid or 1 2 -hydroxystearic acid into alginate or zinc alginate spheroids did not substantially retard drug release though these fatty acids were relatively hydrophobic. Overall, the treatment of alginate-based spheroids by microwave tended to bring minor changes in drug release property except that of zinc alginate-1 2 -hydroxystearic acid spheroids where O-H moiety of fatty acid and alginate responded to the influence of microwave.
format Thesis
author Mohd Salleh, Nurul Hidayah
author_facet Mohd Salleh, Nurul Hidayah
author_sort Mohd Salleh, Nurul Hidayah
title Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh
title_short Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh
title_full Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh
title_fullStr Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh
title_full_unstemmed Effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / Nurul Hidayah Mohd Salleh
title_sort effects of microwave on drug release profiles of guluronic acid-rich alginate spheroids / nurul hidayah mohd salleh
publishDate 2015
url https://ir.uitm.edu.my/id/eprint/15671/1/TM_NURUL%20HIDAYAH%20MOHD%20SALLEH%20PH%2015_5.pdf
https://ir.uitm.edu.my/id/eprint/15671/
_version_ 1726795629358743552
score 13.211869

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