MARC表示: Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]

Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]

Introduction: Dexamethasone has been established as an ef f ective prophylactic antiemetic in various studies done in elective surgery. However, its ef f icacy in emergency surgery specif ically, laparoscopic appendicectomy is not well documented. This study was conducted to compare the ef f icacy o...

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主要な著者:	Ng, Shin Ann, Seevaunnamtum, S Praveena, Hassan, Mohamad Hasyizan, Mazlan, Mohd Zulfakar, Che Omar, Sanihah
フォーマット:	論文
言語:	English
出版事項:	Faculty of Medicine 2025
主題:	Surgery by region, system, or organ
オンライン･アクセス:	https://ir.uitm.edu.my/id/eprint/111302/1/111302.pdf https://ir.uitm.edu.my/id/eprint/111302/ http://jchs-medicine.uitm.edu.my/
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id	my.uitm.ir.111302
record_format	eprints
spelling	my.uitm.ir.1113022025-03-13T08:17:24Z https://ir.uitm.edu.my/id/eprint/111302/ Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.] jchs Ng, Shin Ann Seevaunnamtum, S Praveena Hassan, Mohamad Hasyizan Mazlan, Mohd Zulfakar Che Omar, Sanihah Surgery by region, system, or organ Introduction: Dexamethasone has been established as an ef f ective prophylactic antiemetic in various studies done in elective surgery. However, its ef f icacy in emergency surgery specif ically, laparoscopic appendicectomy is not well documented. This study was conducted to compare the ef f icacy of prophylactic intravenous (IV) dexamethasone 8mg in preventing postoperative nausea and vomiting (PONV) in this surgical population. Methods: A total of 84 participants were recruited f or the study in Hospital Universiti Sains Malaysia and were randomly assigned in equal numbers to treatment group with prophylactic IV dexamethasone 8mg or placebo. The outcomes of both groups were taken at three-time intervals; f irst hour, 12 th hour and 24 th hour postoperatively which were proportion of PONV, PONV scores, pain scores and the need f or rescue antiemetic. Results: The group receiving dexamethasone had significantly lower proportion of PONV compared to control group in the first hour postoperatively (dexamethasone vs Control; 16.7% vs 42.9%, P = 0.009) and at 24 hour postoperatively (0% vs 14.3%, P = 0.011). The dexamethasone group also required less rescue antiemetic at the f irst hour (14.3% vs 35.7%, P = 0.023) and 12 th hour postoperatively (0% vs 11.9%, P = 0.021). No signif icant dif ferences in pain scores or PONV scores were found in both groups. Conclusion: Prophylactic dexamethasone reduced postoperative nausea and vomiting (PONV) incidence in the f irst hour and 24 hours post-surgery, decreased the need f or rescue antiemetics in the f irst hour and 12th hour, but did not signif icantly affect analgesia or PONV severity between groups. th Faculty of Medicine 2025-03 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/111302/1/111302.pdf Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]. (2025) Journal of Clinical and Health Sciences (JCHS) <https://ir.uitm.edu.my/view/publication/Journal_of_Clinical_and_Health_Sciences_=28JCHS=29/>, 10 (1). pp. 49-57. ISSN 0127-984X http://jchs-medicine.uitm.edu.my/
institution	Universiti Teknologi Mara
building	Tun Abdul Razak Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Mara
content_source	UiTM Institutional Repository
url_provider	http://ir.uitm.edu.my/
language	English
topic	Surgery by region, system, or organ
spellingShingle	Surgery by region, system, or organ Ng, Shin Ann Seevaunnamtum, S Praveena Hassan, Mohamad Hasyizan Mazlan, Mohd Zulfakar Che Omar, Sanihah Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]
description	Introduction: Dexamethasone has been established as an ef f ective prophylactic antiemetic in various studies done in elective surgery. However, its ef f icacy in emergency surgery specif ically, laparoscopic appendicectomy is not well documented. This study was conducted to compare the ef f icacy of prophylactic intravenous (IV) dexamethasone 8mg in preventing postoperative nausea and vomiting (PONV) in this surgical population. Methods: A total of 84 participants were recruited f or the study in Hospital Universiti Sains Malaysia and were randomly assigned in equal numbers to treatment group with prophylactic IV dexamethasone 8mg or placebo. The outcomes of both groups were taken at three-time intervals; f irst hour, 12 th hour and 24 th hour postoperatively which were proportion of PONV, PONV scores, pain scores and the need f or rescue antiemetic. Results: The group receiving dexamethasone had significantly lower proportion of PONV compared to control group in the first hour postoperatively (dexamethasone vs Control; 16.7% vs 42.9%, P = 0.009) and at 24 hour postoperatively (0% vs 14.3%, P = 0.011). The dexamethasone group also required less rescue antiemetic at the f irst hour (14.3% vs 35.7%, P = 0.023) and 12 th hour postoperatively (0% vs 11.9%, P = 0.021). No signif icant dif ferences in pain scores or PONV scores were found in both groups. Conclusion: Prophylactic dexamethasone reduced postoperative nausea and vomiting (PONV) incidence in the f irst hour and 24 hours post-surgery, decreased the need f or rescue antiemetics in the f irst hour and 12th hour, but did not signif icantly affect analgesia or PONV severity between groups. th
format	Article
author	Ng, Shin Ann Seevaunnamtum, S Praveena Hassan, Mohamad Hasyizan Mazlan, Mohd Zulfakar Che Omar, Sanihah
author_facet	Ng, Shin Ann Seevaunnamtum, S Praveena Hassan, Mohamad Hasyizan Mazlan, Mohd Zulfakar Che Omar, Sanihah
author_sort	Ng, Shin Ann
title	Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]
title_short	Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]
title_full	Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]
title_fullStr	Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]
title_full_unstemmed	Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]
title_sort	efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / ng shin ann ... [et al.]
publisher	Faculty of Medicine
publishDate	2025
url	https://ir.uitm.edu.my/id/eprint/111302/1/111302.pdf https://ir.uitm.edu.my/id/eprint/111302/ http://jchs-medicine.uitm.edu.my/
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score	13.251813

Efficacy of prophylactic dexamethasone on postoperative nausea and vomiting in laparoscopic appendicectomy: a randomized controlled trial / Ng Shin Ann ... [et al.]

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