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Clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / Faiza Naimat ... [et al.]

Introduction: Cancer-associated thrombosis (CAT) is a clinically significant complication that is linked to cancer patients. However, evidence regarding epidemiology of CAT and clinical characteristics in Malaysian cancer patients is very limited. The objective of this study is to investigate baseli...

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Main Authors: Naimat, Faiza, Loganathan Fahrni, Mathumalar, Md Isa, Khairil Anuar, Thiagarajan, Muthukkumaran, Kwok, Wen Ng
Format: Article
Language:English
Published: Faculty of Medicine 2025
Subjects:
Cancer
Online Access:https://ir.uitm.edu.my/id/eprint/111300/1/111300.pdf
https://ir.uitm.edu.my/id/eprint/111300/
http://jchs-medicine.uitm.edu.my/
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spelling my.uitm.ir.1113002025-03-13T08:15:08Z https://ir.uitm.edu.my/id/eprint/111300/ Clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / Faiza Naimat ... [et al.] jchs Naimat, Faiza Loganathan Fahrni, Mathumalar Md Isa, Khairil Anuar Thiagarajan, Muthukkumaran Kwok, Wen Ng Cancer Introduction: Cancer-associated thrombosis (CAT) is a clinically significant complication that is linked to cancer patients. However, evidence regarding epidemiology of CAT and clinical characteristics in Malaysian cancer patients is very limited. The objective of this study is to investigate baseline characteristics of cancer patient with VTE and clinical profile of the VTE event. Methods: There were 462 cancer patients who were in anticoagulant recipient list from Radiology and Oncology Pharmacy Department, Hospital Kuala Lumpur between 2018 and 2021. A total of 208 patients met the inclusion and exclusion criteria of our study. We analysed retrospectively with respect to underlying diseases or predisposing factors. Results: Mean age of CAT patient was 50.51 years old and body mass index was normal (24.01kg/m ). Patients were mostly having good performance status (0-1). The prevalence rates of CAT were higher in breast, gynaecology and lung. About 63% of the cases experienced DVT, 27.3% had pulmonary embolism and 9.6% of the cases experienced both DVT and PE. Lower extremities DVT was prevalence (28.4%) and followed by upper extremities DVT. Slightly more than 50% of the cases developed VTE within 3 months of cancer diagnosis. Conclusion: The clinical profiles of CAT in our study were different with patients in the West. Nevertheless, risk factors for cancer-related thrombosis found in our study were much consistent with current literature from Asia. The findings in this study may gave an insight on the direction of management of CAT and improve thromboprophylaxis strategies among newly diagnosed cancer patient. 2 Faculty of Medicine 2025-03 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/111300/1/111300.pdf Clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / Faiza Naimat ... [et al.]. (2025) Journal of Clinical and Health Sciences (JCHS) <https://ir.uitm.edu.my/view/publication/Journal_of_Clinical_and_Health_Sciences_=28JCHS=29/>, 10 (1). pp. 29-38. ISSN 0127-984X http://jchs-medicine.uitm.edu.my/
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Cancer
spellingShingle Cancer
Naimat, Faiza
Loganathan Fahrni, Mathumalar
Md Isa, Khairil Anuar
Thiagarajan, Muthukkumaran
Kwok, Wen Ng
Clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / Faiza Naimat ... [et al.]
description Introduction: Cancer-associated thrombosis (CAT) is a clinically significant complication that is linked to cancer patients. However, evidence regarding epidemiology of CAT and clinical characteristics in Malaysian cancer patients is very limited. The objective of this study is to investigate baseline characteristics of cancer patient with VTE and clinical profile of the VTE event. Methods: There were 462 cancer patients who were in anticoagulant recipient list from Radiology and Oncology Pharmacy Department, Hospital Kuala Lumpur between 2018 and 2021. A total of 208 patients met the inclusion and exclusion criteria of our study. We analysed retrospectively with respect to underlying diseases or predisposing factors. Results: Mean age of CAT patient was 50.51 years old and body mass index was normal (24.01kg/m ). Patients were mostly having good performance status (0-1). The prevalence rates of CAT were higher in breast, gynaecology and lung. About 63% of the cases experienced DVT, 27.3% had pulmonary embolism and 9.6% of the cases experienced both DVT and PE. Lower extremities DVT was prevalence (28.4%) and followed by upper extremities DVT. Slightly more than 50% of the cases developed VTE within 3 months of cancer diagnosis. Conclusion: The clinical profiles of CAT in our study were different with patients in the West. Nevertheless, risk factors for cancer-related thrombosis found in our study were much consistent with current literature from Asia. The findings in this study may gave an insight on the direction of management of CAT and improve thromboprophylaxis strategies among newly diagnosed cancer patient. 2
format Article
author Naimat, Faiza
Loganathan Fahrni, Mathumalar
Md Isa, Khairil Anuar
Thiagarajan, Muthukkumaran
Kwok, Wen Ng
author_facet Naimat, Faiza
Loganathan Fahrni, Mathumalar
Md Isa, Khairil Anuar
Thiagarajan, Muthukkumaran
Kwok, Wen Ng
author_sort Naimat, Faiza
title Clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / Faiza Naimat ... [et al.]
title_short Clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / Faiza Naimat ... [et al.]
title_full Clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / Faiza Naimat ... [et al.]
title_fullStr Clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / Faiza Naimat ... [et al.]
title_full_unstemmed Clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / Faiza Naimat ... [et al.]
title_sort clinical profiles of cancer-associated thrombosis among newly diagnosed patient with solid cancer / faiza naimat ... [et al.]
publisher Faculty of Medicine
publishDate 2025
url https://ir.uitm.edu.my/id/eprint/111300/1/111300.pdf
https://ir.uitm.edu.my/id/eprint/111300/
http://jchs-medicine.uitm.edu.my/
_version_ 1827446632261615616
score 13.250246

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