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Safety and efficacy of warfarin in treating atrial fibrillation / Mohamad Amal Shamsul Jasmi

Background: Warfarin is an oral anticoagulant that inhibits the synthesis of vitamin K in the body. It mainly acts as the prophylaxis of stroke for atrial fibrillation patients. This study aimed to evaluate the safety and efficacy of warfarin in the first six months of treatment by evaluating Time i...

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Main Author: Shamsul Jasmi, Mohamad Amal
Format: Thesis
Language:English
Published: 2014
Subjects:
Pharmacopoeias
Online Access:https://ir.uitm.edu.my/id/eprint/111235/1/111235.PDF
https://ir.uitm.edu.my/id/eprint/111235/
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spelling my.uitm.ir.1112352025-03-04T23:10:20Z https://ir.uitm.edu.my/id/eprint/111235/ Safety and efficacy of warfarin in treating atrial fibrillation / Mohamad Amal Shamsul Jasmi Shamsul Jasmi, Mohamad Amal Pharmacopoeias Background: Warfarin is an oral anticoagulant that inhibits the synthesis of vitamin K in the body. It mainly acts as the prophylaxis of stroke for atrial fibrillation patients. This study aimed to evaluate the safety and efficacy of warfarin in the first six months of treatment by evaluating Time in Therapeutic Range of patients and evaluating CHADS2 V ASc and HASBLED score and their relationship to stroke and bleeding incidences. Results and Discussions: A total of 167 data of patients were collected retrospectively. In 157 patients, TTR were found to be outside its intended range (>75%) with 45 of them experienced bleeding in the first six months of warfarin treatment. While only two patients out of ten with TTR >75% experienced bleeding. None of these patients experienced stroke. Bleeding incidences were found to increase with increasing HASBLED score with bleeding occurring at score more than 3. There were a total of 47 patients experiencing bleeding incidences with 42 of them being minor bleeding. The highest identified occurring reason of INR readings out of range was found to be patient non-compliance which was seen in 46 patients. However, the cause was unidentified in 64 patients. Conclusion: There would be a problem maintaining TTR at >75% for the first 6 months. However for TTR less than <75%, bleeding incidence was found to be low which affects only 29% of them. No incidence of stroke was recorded. This shows that warfarin could be both effective and safe in the prevention of stroke in AF patients providing that proper management guidelines were followed. 2014 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/111235/1/111235.PDF Safety and efficacy of warfarin in treating atrial fibrillation / Mohamad Amal Shamsul Jasmi. (2014) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
spellingShingle Pharmacopoeias
Shamsul Jasmi, Mohamad Amal
Safety and efficacy of warfarin in treating atrial fibrillation / Mohamad Amal Shamsul Jasmi
description Background: Warfarin is an oral anticoagulant that inhibits the synthesis of vitamin K in the body. It mainly acts as the prophylaxis of stroke for atrial fibrillation patients. This study aimed to evaluate the safety and efficacy of warfarin in the first six months of treatment by evaluating Time in Therapeutic Range of patients and evaluating CHADS2 V ASc and HASBLED score and their relationship to stroke and bleeding incidences. Results and Discussions: A total of 167 data of patients were collected retrospectively. In 157 patients, TTR were found to be outside its intended range (>75%) with 45 of them experienced bleeding in the first six months of warfarin treatment. While only two patients out of ten with TTR >75% experienced bleeding. None of these patients experienced stroke. Bleeding incidences were found to increase with increasing HASBLED score with bleeding occurring at score more than 3. There were a total of 47 patients experiencing bleeding incidences with 42 of them being minor bleeding. The highest identified occurring reason of INR readings out of range was found to be patient non-compliance which was seen in 46 patients. However, the cause was unidentified in 64 patients. Conclusion: There would be a problem maintaining TTR at >75% for the first 6 months. However for TTR less than <75%, bleeding incidence was found to be low which affects only 29% of them. No incidence of stroke was recorded. This shows that warfarin could be both effective and safe in the prevention of stroke in AF patients providing that proper management guidelines were followed.
format Thesis
author Shamsul Jasmi, Mohamad Amal
author_facet Shamsul Jasmi, Mohamad Amal
author_sort Shamsul Jasmi, Mohamad Amal
title Safety and efficacy of warfarin in treating atrial fibrillation / Mohamad Amal Shamsul Jasmi
title_short Safety and efficacy of warfarin in treating atrial fibrillation / Mohamad Amal Shamsul Jasmi
title_full Safety and efficacy of warfarin in treating atrial fibrillation / Mohamad Amal Shamsul Jasmi
title_fullStr Safety and efficacy of warfarin in treating atrial fibrillation / Mohamad Amal Shamsul Jasmi
title_full_unstemmed Safety and efficacy of warfarin in treating atrial fibrillation / Mohamad Amal Shamsul Jasmi
title_sort safety and efficacy of warfarin in treating atrial fibrillation / mohamad amal shamsul jasmi
publishDate 2014
url https://ir.uitm.edu.my/id/eprint/111235/1/111235.PDF
https://ir.uitm.edu.my/id/eprint/111235/
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score 13.244413

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