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Development of a PCR method for the detection of genetic polymorphism of BRCA1 / Nur Farhah Busyra Ismail

Breast cancer is one of the most common malignancies in women. It continues to be a major burden and cause of death among women worldwide. Several epidemiologic studies have identified risk factors for breast cancer, including a family history of the disease. There are several genes that have been r...

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書誌詳細
第一著者: Ismail, Nur Farhah Busyra
フォーマット: 学位論文
言語:English
出版事項: 2014
主題:
Cancer
Pharmacopoeias
オンライン･アクセス:https://ir.uitm.edu.my/id/eprint/111234/1/111234.PDF
https://ir.uitm.edu.my/id/eprint/111234/
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id my.uitm.ir.111234
record_format eprints
spelling my.uitm.ir.1112342025-03-23T23:59:35Z https://ir.uitm.edu.my/id/eprint/111234/ Development of a PCR method for the detection of genetic polymorphism of BRCA1 / Nur Farhah Busyra Ismail Ismail, Nur Farhah Busyra Cancer Pharmacopoeias Breast cancer is one of the most common malignancies in women. It continues to be a major burden and cause of death among women worldwide. Several epidemiologic studies have identified risk factors for breast cancer, including a family history of the disease. There are several genes that have been reported associated with breast cancer and one of them is BRCAJ gene. BRCAJ gene is a key role that acts as suppressor gene which is inherited as an autosomal dominant. This study aims to develop a diagnostic test for genetic determination of breast cancer risk by detection of BRCAJ which may be associated with breast cancer. Thus, in this study, a set of primers was designed and polymerase chain reaction based detection method was developed to detect polymorphism of BRCA 1. It is important to study on the association of breast cancer with BRCAJ gene to help further development in clinical studies and improvement of quality of life in world population especially Asian country. 2014 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/111234/1/111234.PDF Development of a PCR method for the detection of genetic polymorphism of BRCA1 / Nur Farhah Busyra Ismail. (2014) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Cancer
Pharmacopoeias
spellingShingle Cancer
Pharmacopoeias
Ismail, Nur Farhah Busyra
Development of a PCR method for the detection of genetic polymorphism of BRCA1 / Nur Farhah Busyra Ismail
description Breast cancer is one of the most common malignancies in women. It continues to be a major burden and cause of death among women worldwide. Several epidemiologic studies have identified risk factors for breast cancer, including a family history of the disease. There are several genes that have been reported associated with breast cancer and one of them is BRCAJ gene. BRCAJ gene is a key role that acts as suppressor gene which is inherited as an autosomal dominant. This study aims to develop a diagnostic test for genetic determination of breast cancer risk by detection of BRCAJ which may be associated with breast cancer. Thus, in this study, a set of primers was designed and polymerase chain reaction based detection method was developed to detect polymorphism of BRCA 1. It is important to study on the association of breast cancer with BRCAJ gene to help further development in clinical studies and improvement of quality of life in world population especially Asian country.
format Thesis
author Ismail, Nur Farhah Busyra
author_facet Ismail, Nur Farhah Busyra
author_sort Ismail, Nur Farhah Busyra
title Development of a PCR method for the detection of genetic polymorphism of BRCA1 / Nur Farhah Busyra Ismail
title_short Development of a PCR method for the detection of genetic polymorphism of BRCA1 / Nur Farhah Busyra Ismail
title_full Development of a PCR method for the detection of genetic polymorphism of BRCA1 / Nur Farhah Busyra Ismail
title_fullStr Development of a PCR method for the detection of genetic polymorphism of BRCA1 / Nur Farhah Busyra Ismail
title_full_unstemmed Development of a PCR method for the detection of genetic polymorphism of BRCA1 / Nur Farhah Busyra Ismail
title_sort development of a pcr method for the detection of genetic polymorphism of brca1 / nur farhah busyra ismail
publishDate 2014
url https://ir.uitm.edu.my/id/eprint/111234/1/111234.PDF
https://ir.uitm.edu.my/id/eprint/111234/
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score 13.251813

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