Cover Image

Design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'Aisyah Ab Malek

The significant of this study is to design and synthesis a chemical probe of glutathione (GSH). Originally, Fe2+ catechol appendent Zn2+ - cyclen complexes was proposed having a potential chemical structure for GSH. However, due to uncommercialised available of catechol, this study was conducted by...

Full description

Saved in:
Bibliographic Details
Main Author: Ab Malek, 'Aisyah
Format: Thesis
Language:English
Published: 2014
Subjects:
Pharmacopoeias
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/111225/1/111225.PDF
https://ir.uitm.edu.my/id/eprint/111225/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.uitm.ir.111225
record_format eprints
spelling my.uitm.ir.1112252025-03-04T23:12:58Z https://ir.uitm.edu.my/id/eprint/111225/ Design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'Aisyah Ab Malek Ab Malek, 'Aisyah Pharmacopoeias Pharmaceutical chemistry The significant of this study is to design and synthesis a chemical probe of glutathione (GSH). Originally, Fe2+ catechol appendent Zn2+ - cyclen complexes was proposed having a potential chemical structure for GSH. However, due to uncommercialised available of catechol, this study was conducted by using 2 Zn2+ - cyclen complexes instead of Fe2+ catechol. The hypothesis of this study is one linker compound that appended of 2 Zn2+ - cyclen complexes at certain distance, can detect one GSSG molecule. The methods of this study consist of 2 parts which is synthesis and analysis part. The first step in synthesis part was conversion of free cyclen from cyclen tetrahydrochloride salt. Then, three amine groups on the cyclen were protected using Boe-protecting group. The third step was, coupling of tri-Boc protected cyclen with di­ bromomethyl phenyloxy propane and the forth step was Boe deprotecting of cyclen. The synthesis part of this study consists of five steps in total. However, due to time restriction, the last step in synthesis part cannot be done and analysis part cannot be proceed. Nevertheless, the designed probe can be synthesis and the data from analysis part may support the hypothesis made if this study continues. 2014 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/111225/1/111225.PDF Design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'Aisyah Ab Malek. (2014) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
Pharmaceutical chemistry
spellingShingle Pharmacopoeias
Pharmaceutical chemistry
Ab Malek, 'Aisyah
Design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'Aisyah Ab Malek
description The significant of this study is to design and synthesis a chemical probe of glutathione (GSH). Originally, Fe2+ catechol appendent Zn2+ - cyclen complexes was proposed having a potential chemical structure for GSH. However, due to uncommercialised available of catechol, this study was conducted by using 2 Zn2+ - cyclen complexes instead of Fe2+ catechol. The hypothesis of this study is one linker compound that appended of 2 Zn2+ - cyclen complexes at certain distance, can detect one GSSG molecule. The methods of this study consist of 2 parts which is synthesis and analysis part. The first step in synthesis part was conversion of free cyclen from cyclen tetrahydrochloride salt. Then, three amine groups on the cyclen were protected using Boe-protecting group. The third step was, coupling of tri-Boc protected cyclen with di­ bromomethyl phenyloxy propane and the forth step was Boe deprotecting of cyclen. The synthesis part of this study consists of five steps in total. However, due to time restriction, the last step in synthesis part cannot be done and analysis part cannot be proceed. Nevertheless, the designed probe can be synthesis and the data from analysis part may support the hypothesis made if this study continues.
format Thesis
author Ab Malek, 'Aisyah
author_facet Ab Malek, 'Aisyah
author_sort Ab Malek, 'Aisyah
title Design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'Aisyah Ab Malek
title_short Design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'Aisyah Ab Malek
title_full Design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'Aisyah Ab Malek
title_fullStr Design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'Aisyah Ab Malek
title_full_unstemmed Design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'Aisyah Ab Malek
title_sort design and synthesis of fe2+ catechol appendent zn2+cyclen complex / 'aisyah ab malek
publishDate 2014
url https://ir.uitm.edu.my/id/eprint/111225/1/111225.PDF
https://ir.uitm.edu.my/id/eprint/111225/
_version_ 1825814861471285248
score 13.244413

Similar Items