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The effects of surfactants on the permeation of caffeine cream using franz diffusion cell / Mastura Omar

Caffeine is commonly used as a model of hydrophilic drug because of its ability to permeate through the skin. It is also used as an active compound in many commercial preparations such as anti-cellulite cream, gels, moisturizers, serums and shampoos. However, the stratum corneum which is the hydroph...

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Main Author: Omar, Mastura
Format: Thesis
Language:English
Published: 2014
Subjects:
Drugs prescribing
Drugs and their actions
Pharmacopoeias
Online Access:https://ir.uitm.edu.my/id/eprint/111127/1/111127.PDF
https://ir.uitm.edu.my/id/eprint/111127/
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spelling my.uitm.ir.1111272025-03-04T23:14:21Z https://ir.uitm.edu.my/id/eprint/111127/ The effects of surfactants on the permeation of caffeine cream using franz diffusion cell / Mastura Omar Omar, Mastura Drugs prescribing Drugs and their actions Pharmacopoeias Caffeine is commonly used as a model of hydrophilic drug because of its ability to permeate through the skin. It is also used as an active compound in many commercial preparations such as anti-cellulite cream, gels, moisturizers, serums and shampoos. However, the stratum corneum which is the hydrophobic layer of the epidermis of skin is the main protective barrier for to the caffeine to pass through the skin. The aim of this study was to investigate the caffeine cream permeation profile with or without co-administration of surfactants including Cremophor EL, Labrasol, Labrafil through the synthetic membrane and rat skin by using Franz diffusion cell. The cumulative permeation amount of caffeine cream with presence of surfactants (Cremophor EL, Labrasol, Labrafil) showed higher permeation rate compared to caffeine cream (control). Among surfactants used, the presence of Labrasol in caffeine cream significantly (p<0.05) increased the caffeine permeation through synthetic membrane and rat skin. The use of Labrasol in the caffeine cream formulation has the potential to increase the permeation rate through transdermal delivery, thus, increase its therapeutic effects. 2014 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/111127/1/111127.PDF The effects of surfactants on the permeation of caffeine cream using franz diffusion cell / Mastura Omar. (2014) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Drugs prescribing
Drugs and their actions
Pharmacopoeias
spellingShingle Drugs prescribing
Drugs and their actions
Pharmacopoeias
Omar, Mastura
The effects of surfactants on the permeation of caffeine cream using franz diffusion cell / Mastura Omar
description Caffeine is commonly used as a model of hydrophilic drug because of its ability to permeate through the skin. It is also used as an active compound in many commercial preparations such as anti-cellulite cream, gels, moisturizers, serums and shampoos. However, the stratum corneum which is the hydrophobic layer of the epidermis of skin is the main protective barrier for to the caffeine to pass through the skin. The aim of this study was to investigate the caffeine cream permeation profile with or without co-administration of surfactants including Cremophor EL, Labrasol, Labrafil through the synthetic membrane and rat skin by using Franz diffusion cell. The cumulative permeation amount of caffeine cream with presence of surfactants (Cremophor EL, Labrasol, Labrafil) showed higher permeation rate compared to caffeine cream (control). Among surfactants used, the presence of Labrasol in caffeine cream significantly (p<0.05) increased the caffeine permeation through synthetic membrane and rat skin. The use of Labrasol in the caffeine cream formulation has the potential to increase the permeation rate through transdermal delivery, thus, increase its therapeutic effects.
format Thesis
author Omar, Mastura
author_facet Omar, Mastura
author_sort Omar, Mastura
title The effects of surfactants on the permeation of caffeine cream using franz diffusion cell / Mastura Omar
title_short The effects of surfactants on the permeation of caffeine cream using franz diffusion cell / Mastura Omar
title_full The effects of surfactants on the permeation of caffeine cream using franz diffusion cell / Mastura Omar
title_fullStr The effects of surfactants on the permeation of caffeine cream using franz diffusion cell / Mastura Omar
title_full_unstemmed The effects of surfactants on the permeation of caffeine cream using franz diffusion cell / Mastura Omar
title_sort effects of surfactants on the permeation of caffeine cream using franz diffusion cell / mastura omar
publishDate 2014
url https://ir.uitm.edu.my/id/eprint/111127/1/111127.PDF
https://ir.uitm.edu.my/id/eprint/111127/
_version_ 1825814855547879424
score 13.244413

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