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Oral absorption study of levodopa­-loaded chitosan microparticles / Mohamad Zhafran Kamaruzaman

Levodopa is the most common drug that has been used to treat Parkinson Disease. This study was conducted to increase the bioavailability of levodopa after size reduction andto study the pharmacokinetic profiles of levodopa loaded chitosan microparticles after oral administration. Levodopa-loaded chi...

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Main Author: Kamaruzaman, Mohamad Zhafran
Format: Thesis
Language:English
Published: 2014
Subjects:
Drugs prescribing
Drugs and their actions
Online Access:https://ir.uitm.edu.my/id/eprint/111119/1/111119.PDF
https://ir.uitm.edu.my/id/eprint/111119/
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spelling my.uitm.ir.1111192025-03-04T23:16:42Z https://ir.uitm.edu.my/id/eprint/111119/ Oral absorption study of levodopa­-loaded chitosan microparticles / Mohamad Zhafran Kamaruzaman Kamaruzaman, Mohamad Zhafran Drugs prescribing Drugs and their actions Levodopa is the most common drug that has been used to treat Parkinson Disease. This study was conducted to increase the bioavailability of levodopa after size reduction andto study the pharmacokinetic profiles of levodopa loaded chitosan microparticles after oral administration. Levodopa-loaded chitosan microparticles has been formulated by using ionic gelation method. The characterization of microparticle was carried out by using Malvern Particle Size Analyzer to evaluate the mean particle size and uniformity of levodopa-loaded chitosan microparticle which was 39.9 µm. By using Scanning Electron Microscopy (SEM), the morphology of the levodopa loaded chitosan microparticle showed levodopa was encapsulated in the chitosan-sodium TPP polymer. The value of drug entrapment efficiency for the levodopa loaded chitosan was 75.06%. Fourier Transform Infrared (FTIR) showed that there was interaction and extension of hydrogen bonding between sodium TPP. The characterization by using X-Ray Diffraction showed the amorphous state of levodopa loaded chitosan after blended with chitosan. By pharmacokinetic study, it showed AUC value was 5664.19±132µglml.min as compared to the control (3436.17±385.52). The concentration of levodopa microparticles was significantly increased (p <0.05) as compared to unprocessed levodopa. 2014 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/111119/1/111119.PDF Oral absorption study of levodopa­-loaded chitosan microparticles / Mohamad Zhafran Kamaruzaman. (2014) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Drugs prescribing
Drugs and their actions
spellingShingle Drugs prescribing
Drugs and their actions
Kamaruzaman, Mohamad Zhafran
Oral absorption study of levodopa­-loaded chitosan microparticles / Mohamad Zhafran Kamaruzaman
description Levodopa is the most common drug that has been used to treat Parkinson Disease. This study was conducted to increase the bioavailability of levodopa after size reduction andto study the pharmacokinetic profiles of levodopa loaded chitosan microparticles after oral administration. Levodopa-loaded chitosan microparticles has been formulated by using ionic gelation method. The characterization of microparticle was carried out by using Malvern Particle Size Analyzer to evaluate the mean particle size and uniformity of levodopa-loaded chitosan microparticle which was 39.9 µm. By using Scanning Electron Microscopy (SEM), the morphology of the levodopa loaded chitosan microparticle showed levodopa was encapsulated in the chitosan-sodium TPP polymer. The value of drug entrapment efficiency for the levodopa loaded chitosan was 75.06%. Fourier Transform Infrared (FTIR) showed that there was interaction and extension of hydrogen bonding between sodium TPP. The characterization by using X-Ray Diffraction showed the amorphous state of levodopa loaded chitosan after blended with chitosan. By pharmacokinetic study, it showed AUC value was 5664.19±132µglml.min as compared to the control (3436.17±385.52). The concentration of levodopa microparticles was significantly increased (p <0.05) as compared to unprocessed levodopa.
format Thesis
author Kamaruzaman, Mohamad Zhafran
author_facet Kamaruzaman, Mohamad Zhafran
author_sort Kamaruzaman, Mohamad Zhafran
title Oral absorption study of levodopa­-loaded chitosan microparticles / Mohamad Zhafran Kamaruzaman
title_short Oral absorption study of levodopa­-loaded chitosan microparticles / Mohamad Zhafran Kamaruzaman
title_full Oral absorption study of levodopa­-loaded chitosan microparticles / Mohamad Zhafran Kamaruzaman
title_fullStr Oral absorption study of levodopa­-loaded chitosan microparticles / Mohamad Zhafran Kamaruzaman
title_full_unstemmed Oral absorption study of levodopa­-loaded chitosan microparticles / Mohamad Zhafran Kamaruzaman
title_sort oral absorption study of levodopa­-loaded chitosan microparticles / mohamad zhafran kamaruzaman
publishDate 2014
url https://ir.uitm.edu.my/id/eprint/111119/1/111119.PDF
https://ir.uitm.edu.my/id/eprint/111119/
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score 13.244413

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