Cover Image

Safety and efficacy of warfarin in treating atrial fibrillation / Muhamad Nazrin Mazlan

Background: Warfarin is an anticoagulant that inhibits the production of Vitamin K. It is used as in prevention of stroke in atrial fibrillation patients. This study aimed to evaluate the safety and efficacy of warfarin in the second six months of treatment by evaluating Time in Therapeutic Range of...

Full description

Saved in:
Bibliographic Details
Main Author: Mazlan, Muhamad Nazrin
Format: Thesis
Language:English
Published: 2014
Subjects:
Pharmacopoeias
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/111116/1/111116.PDF
https://ir.uitm.edu.my/id/eprint/111116/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.uitm.ir.111116
record_format eprints
spelling my.uitm.ir.1111162025-03-04T23:14:36Z https://ir.uitm.edu.my/id/eprint/111116/ Safety and efficacy of warfarin in treating atrial fibrillation / Muhamad Nazrin Mazlan Mazlan, Muhamad Nazrin Pharmacopoeias Pharmaceutical chemistry Background: Warfarin is an anticoagulant that inhibits the production of Vitamin K. It is used as in prevention of stroke in atrial fibrillation patients. This study aimed to evaluate the safety and efficacy of warfarin in the second six months of treatment by evaluating Time in Therapeutic Range of patients and evaluating CHADS2 V ASc and HASBLED score and their relationship to stroke and bleeding incidences. Results and Discussions: A total of 167data of patients were collected retrospectively. Out of 139 patients who had TTR outside the intended range (<75%) 26 experienced bleeding and I had stroke in the second six months of treatment. From 28 patients who had TTR >75%, 4 experienced bleeding and none had stroke. Increase HASBLED score showed increase bleeding and increase risk of major bleeding event. The common reason for INR outside range was drug interaction and side effects with 39.5% (n=66) patient. Conclusion: The number of patients with TTR >75% (n=28) was lesser than TTR <75% (n=139). The incidence of bleeding was lower in 26 out of 139 who experienced bleeding with TTR <75%. This shows that warfarin could be safe in prevention of stroke with a management and follow up. 2014 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/111116/1/111116.PDF Safety and efficacy of warfarin in treating atrial fibrillation / Muhamad Nazrin Mazlan. (2014) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
Pharmaceutical chemistry
spellingShingle Pharmacopoeias
Pharmaceutical chemistry
Mazlan, Muhamad Nazrin
Safety and efficacy of warfarin in treating atrial fibrillation / Muhamad Nazrin Mazlan
description Background: Warfarin is an anticoagulant that inhibits the production of Vitamin K. It is used as in prevention of stroke in atrial fibrillation patients. This study aimed to evaluate the safety and efficacy of warfarin in the second six months of treatment by evaluating Time in Therapeutic Range of patients and evaluating CHADS2 V ASc and HASBLED score and their relationship to stroke and bleeding incidences. Results and Discussions: A total of 167data of patients were collected retrospectively. Out of 139 patients who had TTR outside the intended range (<75%) 26 experienced bleeding and I had stroke in the second six months of treatment. From 28 patients who had TTR >75%, 4 experienced bleeding and none had stroke. Increase HASBLED score showed increase bleeding and increase risk of major bleeding event. The common reason for INR outside range was drug interaction and side effects with 39.5% (n=66) patient. Conclusion: The number of patients with TTR >75% (n=28) was lesser than TTR <75% (n=139). The incidence of bleeding was lower in 26 out of 139 who experienced bleeding with TTR <75%. This shows that warfarin could be safe in prevention of stroke with a management and follow up.
format Thesis
author Mazlan, Muhamad Nazrin
author_facet Mazlan, Muhamad Nazrin
author_sort Mazlan, Muhamad Nazrin
title Safety and efficacy of warfarin in treating atrial fibrillation / Muhamad Nazrin Mazlan
title_short Safety and efficacy of warfarin in treating atrial fibrillation / Muhamad Nazrin Mazlan
title_full Safety and efficacy of warfarin in treating atrial fibrillation / Muhamad Nazrin Mazlan
title_fullStr Safety and efficacy of warfarin in treating atrial fibrillation / Muhamad Nazrin Mazlan
title_full_unstemmed Safety and efficacy of warfarin in treating atrial fibrillation / Muhamad Nazrin Mazlan
title_sort safety and efficacy of warfarin in treating atrial fibrillation / muhamad nazrin mazlan
publishDate 2014
url https://ir.uitm.edu.my/id/eprint/111116/1/111116.PDF
https://ir.uitm.edu.my/id/eprint/111116/
_version_ 1825814854063095808
score 13.244413

Similar Items