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In vitro skin permeation study of medium-chain triacylglycerols (MCTs) / Zulkefli Mohamad

Many approaches have been used to increase the low permeability of the drug through the skin. One of them is by including permeation enhancers such as medium chain triacylglycerols (MCTs). These agent, reversibly alter the barrier resistance of the stratum comeum and allow the drug to permeate into...

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Main Author: Mohamad, Zulkefli
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/110534/1/110534.PDF
https://ir.uitm.edu.my/id/eprint/110534/
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spelling my.uitm.ir.1105342025-02-18T18:05:04Z https://ir.uitm.edu.my/id/eprint/110534/ In vitro skin permeation study of medium-chain triacylglycerols (MCTs) / Zulkefli Mohamad Mohamad, Zulkefli Pharmaceutical chemistry Many approaches have been used to increase the low permeability of the drug through the skin. One of them is by including permeation enhancers such as medium chain triacylglycerols (MCTs). These agent, reversibly alter the barrier resistance of the stratum comeum and allow the drug to permeate into the viable epidermis and systemic circulation. This study was carried out to evaluate the in vitro skin permeation of n-tocopherol, the model antioxidant in different MCTs namely virgin coconut oil (VCO) and structured virgin coconut oil (SVCO) creams. VCO is rich in lauric acid (60%) while SVCO which was produced by lipase catalysed acidolysis of caprylic acid and VCO contains highly in caprylic acid (60%). The skin permeation of u-tocopherol in the formulation was measured for 24 hour test through the finite dose technique using Franz diffusion cells. The 24 hour skin permeation of a­ tocopherol using synthetic membrane shows greater release rate in SVCO cream than the VCO cream with the maximum flux rate of 0.57 mg/cmvh and 0.4 mg/cm/h, respectively. The in vitro skin permeation study using rat's skin showed no absorption profile, however results of the stratum corneum and viable epidermis extracts showed higher amount of n-tocopherol in the skin applied with the SVCO cream compared to the VCO cream. Amounts of n-tocopherol recovered from the stratum comeum and viable epidermis in VCO and SVCO creams were 93.43 µg/ml, 121.18µg/ml, 99 .3 7µg/ml and 151.01µg/ml respectively. These results revealed that triacylglycerols (TAGs) carbon chain lengths influence the permeation of the 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/110534/1/110534.PDF In vitro skin permeation study of medium-chain triacylglycerols (MCTs) / Zulkefli Mohamad. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical chemistry
spellingShingle Pharmaceutical chemistry
Mohamad, Zulkefli
In vitro skin permeation study of medium-chain triacylglycerols (MCTs) / Zulkefli Mohamad
description Many approaches have been used to increase the low permeability of the drug through the skin. One of them is by including permeation enhancers such as medium chain triacylglycerols (MCTs). These agent, reversibly alter the barrier resistance of the stratum comeum and allow the drug to permeate into the viable epidermis and systemic circulation. This study was carried out to evaluate the in vitro skin permeation of n-tocopherol, the model antioxidant in different MCTs namely virgin coconut oil (VCO) and structured virgin coconut oil (SVCO) creams. VCO is rich in lauric acid (60%) while SVCO which was produced by lipase catalysed acidolysis of caprylic acid and VCO contains highly in caprylic acid (60%). The skin permeation of u-tocopherol in the formulation was measured for 24 hour test through the finite dose technique using Franz diffusion cells. The 24 hour skin permeation of a­ tocopherol using synthetic membrane shows greater release rate in SVCO cream than the VCO cream with the maximum flux rate of 0.57 mg/cmvh and 0.4 mg/cm/h, respectively. The in vitro skin permeation study using rat's skin showed no absorption profile, however results of the stratum corneum and viable epidermis extracts showed higher amount of n-tocopherol in the skin applied with the SVCO cream compared to the VCO cream. Amounts of n-tocopherol recovered from the stratum comeum and viable epidermis in VCO and SVCO creams were 93.43 µg/ml, 121.18µg/ml, 99 .3 7µg/ml and 151.01µg/ml respectively. These results revealed that triacylglycerols (TAGs) carbon chain lengths influence the permeation of the
format Thesis
author Mohamad, Zulkefli
author_facet Mohamad, Zulkefli
author_sort Mohamad, Zulkefli
title In vitro skin permeation study of medium-chain triacylglycerols (MCTs) / Zulkefli Mohamad
title_short In vitro skin permeation study of medium-chain triacylglycerols (MCTs) / Zulkefli Mohamad
title_full In vitro skin permeation study of medium-chain triacylglycerols (MCTs) / Zulkefli Mohamad
title_fullStr In vitro skin permeation study of medium-chain triacylglycerols (MCTs) / Zulkefli Mohamad
title_full_unstemmed In vitro skin permeation study of medium-chain triacylglycerols (MCTs) / Zulkefli Mohamad
title_sort in vitro skin permeation study of medium-chain triacylglycerols (mcts) / zulkefli mohamad
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/110534/1/110534.PDF
https://ir.uitm.edu.my/id/eprint/110534/
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score 13.239859

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