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Cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-PEG-cidtosan based nanoparticles on ER-­ breast cancer cells (MDA 231) / Najihah Mohd Termizi

In recent year, breast cancer has been formed as major cause of mortality rate among Malaysian women. There were few studies that reviewed the most effective drug chemotherapy for breast cancer. Paclitaxel is an anticancer drug that has been used effectively in chemotherapy for various cancers. Howe...

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Main Author: Mohd Termizi, Najihah
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmacopoeias
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/110489/1/110489.PDF
https://ir.uitm.edu.my/id/eprint/110489/
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spelling my.uitm.ir.1104892025-02-21T23:51:53Z https://ir.uitm.edu.my/id/eprint/110489/ Cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-PEG-cidtosan based nanoparticles on ER-­ breast cancer cells (MDA 231) / Najihah Mohd Termizi Mohd Termizi, Najihah Pharmacopoeias Pharmaceutical chemistry In recent year, breast cancer has been formed as major cause of mortality rate among Malaysian women. There were few studies that reviewed the most effective drug chemotherapy for breast cancer. Paclitaxel is an anticancer drug that has been used effectively in chemotherapy for various cancers. However, with its hydrophobic characteristics, it is administered with other compounds which are bringing up various side effects. In present study, effect of Paclitaxel loaded and surface coated Poly-Methacrylic Acid-PEG-Chitosan Based nanoparticle was assessed for their cytotoxic potential against MDA 231 cell lines using SRB assays. The novel formulation showed IC50 value of 4µg/rnl against MDA 23lcell lines.This mean, the Poly-Methacrylic Acid-PEG-Chitosan Based nanoparticles has cytotoxic activity of paclitaxel on MDA 231 cell lines. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/110489/1/110489.PDF Cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-PEG-cidtosan based nanoparticles on ER-­ breast cancer cells (MDA 231) / Najihah Mohd Termizi. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
Pharmaceutical chemistry
spellingShingle Pharmacopoeias
Pharmaceutical chemistry
Mohd Termizi, Najihah
Cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-PEG-cidtosan based nanoparticles on ER-­ breast cancer cells (MDA 231) / Najihah Mohd Termizi
description In recent year, breast cancer has been formed as major cause of mortality rate among Malaysian women. There were few studies that reviewed the most effective drug chemotherapy for breast cancer. Paclitaxel is an anticancer drug that has been used effectively in chemotherapy for various cancers. However, with its hydrophobic characteristics, it is administered with other compounds which are bringing up various side effects. In present study, effect of Paclitaxel loaded and surface coated Poly-Methacrylic Acid-PEG-Chitosan Based nanoparticle was assessed for their cytotoxic potential against MDA 231 cell lines using SRB assays. The novel formulation showed IC50 value of 4µg/rnl against MDA 23lcell lines.This mean, the Poly-Methacrylic Acid-PEG-Chitosan Based nanoparticles has cytotoxic activity of paclitaxel on MDA 231 cell lines.
format Thesis
author Mohd Termizi, Najihah
author_facet Mohd Termizi, Najihah
author_sort Mohd Termizi, Najihah
title Cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-PEG-cidtosan based nanoparticles on ER-­ breast cancer cells (MDA 231) / Najihah Mohd Termizi
title_short Cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-PEG-cidtosan based nanoparticles on ER-­ breast cancer cells (MDA 231) / Najihah Mohd Termizi
title_full Cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-PEG-cidtosan based nanoparticles on ER-­ breast cancer cells (MDA 231) / Najihah Mohd Termizi
title_fullStr Cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-PEG-cidtosan based nanoparticles on ER-­ breast cancer cells (MDA 231) / Najihah Mohd Termizi
title_full_unstemmed Cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-PEG-cidtosan based nanoparticles on ER-­ breast cancer cells (MDA 231) / Najihah Mohd Termizi
title_sort cytotoxicity of paclitaxel loaded and surface coated poly-methacrylic acid­-peg-cidtosan based nanoparticles on er-­ breast cancer cells (mda 231) / najihah mohd termizi
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/110489/1/110489.PDF
https://ir.uitm.edu.my/id/eprint/110489/
_version_ 1825165193738452992
score 13.239859

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