Cover Image

Development of stable gamma linolenic acid (GLA) nanoemulsions / Zarith Nadia Mohamad Zulkifli

Gamma linolenic acid (GLA) is an essential polyunsaturated omega-6 fatty acid that can be found in certain plant oils such as evening primrose oils, black currant seed oils and borage oils. It is a poorly-water soluble drug that is effective in prevention and treatment of various health problems inc...

Full description

Saved in:
Bibliographic Details
Main Author: Mohamad Zulkifli, Zarith Nadia
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmacopoeias
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/110428/1/110428.PDF
https://ir.uitm.edu.my/id/eprint/110428/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.uitm.ir.110428
record_format eprints
spelling my.uitm.ir.1104282025-02-21T23:57:38Z https://ir.uitm.edu.my/id/eprint/110428/ Development of stable gamma linolenic acid (GLA) nanoemulsions / Zarith Nadia Mohamad Zulkifli Mohamad Zulkifli, Zarith Nadia Pharmacopoeias Pharmaceutical chemistry Gamma linolenic acid (GLA) is an essential polyunsaturated omega-6 fatty acid that can be found in certain plant oils such as evening primrose oils, black currant seed oils and borage oils. It is a poorly-water soluble drug that is effective in prevention and treatment of various health problems including for topical application onto the skin. The purpose of this study was to develop a stable GLA nanoemulsion with an acceptable particle size range as well as a good particle size distribution. In this study, several formulations of GLA nanoemulsion were prepared and analysed. GLA was used as the main active ingredient and also as the oil phase, Cremophor® EL and Tween 80 as the surfactant, ethanol as the co-surfactant and distilled water as the aqueous phase. Composition of nanoemulsion systems was optimised by using different types and concentrations of GLA and distilled water, and with or without the addition of co-surfactant. Eight nanoemulsion formulations were prepared, of which composed of GLA oil, Cremophor® EL, with or without addition of Tween 80 or ethanol, and distilled water were made up to 100 %. Particle sizes of the nanoemulsion and stability analysis were done to characterize the nanoemulsions. The result showed that three out of eight formulations developed good characteristics of nanoemulsions. These results indicated that incorporation of appropriate combination of types, quantity and concentrations of surfactant as well as co­ surfactant can enhance the stability, particle size range and particle size distribution of GLA nanoemulsions. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/110428/1/110428.PDF Development of stable gamma linolenic acid (GLA) nanoemulsions / Zarith Nadia Mohamad Zulkifli. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
Pharmaceutical chemistry
spellingShingle Pharmacopoeias
Pharmaceutical chemistry
Mohamad Zulkifli, Zarith Nadia
Development of stable gamma linolenic acid (GLA) nanoemulsions / Zarith Nadia Mohamad Zulkifli
description Gamma linolenic acid (GLA) is an essential polyunsaturated omega-6 fatty acid that can be found in certain plant oils such as evening primrose oils, black currant seed oils and borage oils. It is a poorly-water soluble drug that is effective in prevention and treatment of various health problems including for topical application onto the skin. The purpose of this study was to develop a stable GLA nanoemulsion with an acceptable particle size range as well as a good particle size distribution. In this study, several formulations of GLA nanoemulsion were prepared and analysed. GLA was used as the main active ingredient and also as the oil phase, Cremophor® EL and Tween 80 as the surfactant, ethanol as the co-surfactant and distilled water as the aqueous phase. Composition of nanoemulsion systems was optimised by using different types and concentrations of GLA and distilled water, and with or without the addition of co-surfactant. Eight nanoemulsion formulations were prepared, of which composed of GLA oil, Cremophor® EL, with or without addition of Tween 80 or ethanol, and distilled water were made up to 100 %. Particle sizes of the nanoemulsion and stability analysis were done to characterize the nanoemulsions. The result showed that three out of eight formulations developed good characteristics of nanoemulsions. These results indicated that incorporation of appropriate combination of types, quantity and concentrations of surfactant as well as co­ surfactant can enhance the stability, particle size range and particle size distribution of GLA nanoemulsions.
format Thesis
author Mohamad Zulkifli, Zarith Nadia
author_facet Mohamad Zulkifli, Zarith Nadia
author_sort Mohamad Zulkifli, Zarith Nadia
title Development of stable gamma linolenic acid (GLA) nanoemulsions / Zarith Nadia Mohamad Zulkifli
title_short Development of stable gamma linolenic acid (GLA) nanoemulsions / Zarith Nadia Mohamad Zulkifli
title_full Development of stable gamma linolenic acid (GLA) nanoemulsions / Zarith Nadia Mohamad Zulkifli
title_fullStr Development of stable gamma linolenic acid (GLA) nanoemulsions / Zarith Nadia Mohamad Zulkifli
title_full_unstemmed Development of stable gamma linolenic acid (GLA) nanoemulsions / Zarith Nadia Mohamad Zulkifli
title_sort development of stable gamma linolenic acid (gla) nanoemulsions / zarith nadia mohamad zulkifli
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/110428/1/110428.PDF
https://ir.uitm.edu.my/id/eprint/110428/
_version_ 1825165188642373632
score 13.239859

Similar Items