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In vivo skin permeation study of medium-chain triacylglycerols (MCTSs) / Muhammad Syafiq Aiman Mohd Kamil

This study was carried out to investigate the in vivo skin permeation of u-tocopherol in medium chain triacylglycerols (MCTs) vehicles namely virgin coconut oil (VCO) and structured virgin coconut oil (SVCO) creams. MCTs act as permeation enhancers in pharmaceutical and cosmeceutical formulations. V...

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Main Author: Mohd Kamil, Muhammad Syafiq Aiman
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmacopoeias
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/110421/1/110421.PDF
https://ir.uitm.edu.my/id/eprint/110421/
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spelling my.uitm.ir.1104212025-02-21T23:55:22Z https://ir.uitm.edu.my/id/eprint/110421/ In vivo skin permeation study of medium-chain triacylglycerols (MCTSs) / Muhammad Syafiq Aiman Mohd Kamil Mohd Kamil, Muhammad Syafiq Aiman Pharmacopoeias Pharmaceutical chemistry This study was carried out to investigate the in vivo skin permeation of u-tocopherol in medium chain triacylglycerols (MCTs) vehicles namely virgin coconut oil (VCO) and structured virgin coconut oil (SVCO) creams. MCTs act as permeation enhancers in pharmaceutical and cosmeceutical formulations. VCO contains mainly of 12 carbon chain lengths and lauric acid whereas SVCO which was produced by acidolysis of caprylic acid and VCO contains 60% of caprylic acid with 8 carbon chain lengths. The skin tape- stripping technique was applied to evaluate the level of n-tocopherol retained in the stratum corneum (SC). The amount of u-tocopherol was quantified using high performance liquid chromatography (HPLC). The results showed that both permeation enhancers increased the permeation of u-tocopherol into the stratum corneum, viable skin and the skin surface. The amount of a­ tocopherol recovered from the skin surface by VCO was 55 ± 12% and SVCO was 60 ± 11 %. The amount of u-tocopherol recovery from viable skin by VCO was 6 ± 13% and SVCO was 7 ± 14% while the amount of n-tocopherol recovery from stratum corneum by VCO was 11 ± 12% and SVCO was 12 ± 13% respectively. In conclusion MCTs creams promote the permeation of u-tocopherol into the stratum corneum, viable skin and skin surface by modulating the barrier function of the skin. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/110421/1/110421.PDF In vivo skin permeation study of medium-chain triacylglycerols (MCTSs) / Muhammad Syafiq Aiman Mohd Kamil. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
Pharmaceutical chemistry
spellingShingle Pharmacopoeias
Pharmaceutical chemistry
Mohd Kamil, Muhammad Syafiq Aiman
In vivo skin permeation study of medium-chain triacylglycerols (MCTSs) / Muhammad Syafiq Aiman Mohd Kamil
description This study was carried out to investigate the in vivo skin permeation of u-tocopherol in medium chain triacylglycerols (MCTs) vehicles namely virgin coconut oil (VCO) and structured virgin coconut oil (SVCO) creams. MCTs act as permeation enhancers in pharmaceutical and cosmeceutical formulations. VCO contains mainly of 12 carbon chain lengths and lauric acid whereas SVCO which was produced by acidolysis of caprylic acid and VCO contains 60% of caprylic acid with 8 carbon chain lengths. The skin tape- stripping technique was applied to evaluate the level of n-tocopherol retained in the stratum corneum (SC). The amount of u-tocopherol was quantified using high performance liquid chromatography (HPLC). The results showed that both permeation enhancers increased the permeation of u-tocopherol into the stratum corneum, viable skin and the skin surface. The amount of a­ tocopherol recovered from the skin surface by VCO was 55 ± 12% and SVCO was 60 ± 11 %. The amount of u-tocopherol recovery from viable skin by VCO was 6 ± 13% and SVCO was 7 ± 14% while the amount of n-tocopherol recovery from stratum corneum by VCO was 11 ± 12% and SVCO was 12 ± 13% respectively. In conclusion MCTs creams promote the permeation of u-tocopherol into the stratum corneum, viable skin and skin surface by modulating the barrier function of the skin.
format Thesis
author Mohd Kamil, Muhammad Syafiq Aiman
author_facet Mohd Kamil, Muhammad Syafiq Aiman
author_sort Mohd Kamil, Muhammad Syafiq Aiman
title In vivo skin permeation study of medium-chain triacylglycerols (MCTSs) / Muhammad Syafiq Aiman Mohd Kamil
title_short In vivo skin permeation study of medium-chain triacylglycerols (MCTSs) / Muhammad Syafiq Aiman Mohd Kamil
title_full In vivo skin permeation study of medium-chain triacylglycerols (MCTSs) / Muhammad Syafiq Aiman Mohd Kamil
title_fullStr In vivo skin permeation study of medium-chain triacylglycerols (MCTSs) / Muhammad Syafiq Aiman Mohd Kamil
title_full_unstemmed In vivo skin permeation study of medium-chain triacylglycerols (MCTSs) / Muhammad Syafiq Aiman Mohd Kamil
title_sort in vivo skin permeation study of medium-chain triacylglycerols (mctss) / muhammad syafiq aiman mohd kamil
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/110421/1/110421.PDF
https://ir.uitm.edu.my/id/eprint/110421/
_version_ 1825165187457482752
score 13.239859

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