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Effects of endophytic aspergillus sp. strain HAB10R12's fractions (R1 and R2) on TNF-α induced insulin resistance in differentiated 3T3-L1 adipocytes / Nurul Rahimah Mohd Khair

Insulin is responsible for regulation of glucose uptake and circulating free fatty acids (FF A). When there is insulin resistance, there will be an increased in circulating FF A concentrations and fat accumulation that impede insulin mediated glucose in skeletal muscle and elevated glucose productio...

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Main Author: Mohd Khair, Nurul Rahimah
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmacopoeias
Pharmaceutical chemistry
Online Access:https://ir.uitm.edu.my/id/eprint/110373/1/110373.PDF
https://ir.uitm.edu.my/id/eprint/110373/
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spelling my.uitm.ir.1103732025-02-14T11:59:56Z https://ir.uitm.edu.my/id/eprint/110373/ Effects of endophytic aspergillus sp. strain HAB10R12's fractions (R1 and R2) on TNF-α induced insulin resistance in differentiated 3T3-L1 adipocytes / Nurul Rahimah Mohd Khair Mohd Khair, Nurul Rahimah Pharmacopoeias Pharmaceutical chemistry Insulin is responsible for regulation of glucose uptake and circulating free fatty acids (FF A). When there is insulin resistance, there will be an increased in circulating FF A concentrations and fat accumulation that impede insulin mediated glucose in skeletal muscle and elevated glucose production in liver. This will lead to the development of metabolism problem including Type 2 diabetes which can cause other serious problem such as cancer. Therefore, it is important to find a compound that able to reverse insulin resistance. There is growing evidence that bioactive substance produced by microbial endophytes have applicability in medicine, agriculture and industry . So, the aim of this research is to study the effect from fraction of endophytic Aspergillus sp. strain HAB10R12 (RI and R2) on normal 3T3-L1 adipocytes and insulin resistance 3T3-L1 cell induced by TNF-a. Results in MTT Assay test shown that RI and R2 treatments caused no cytotoxic effects to the normal 3T3-L1 cells and no IC50 value observed in the data. Besides, in glucose uptake test, when compared with the untreated insulin resistance cell, there was in increased in percentage of glucose uptake by insulin in the insulin resistance cell treated both RI and R2 treatments from the lowest concentration up to 0.01 µg/ml. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/110373/1/110373.PDF Effects of endophytic aspergillus sp. strain HAB10R12's fractions (R1 and R2) on TNF-α induced insulin resistance in differentiated 3T3-L1 adipocytes / Nurul Rahimah Mohd Khair. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
Pharmaceutical chemistry
spellingShingle Pharmacopoeias
Pharmaceutical chemistry
Mohd Khair, Nurul Rahimah
Effects of endophytic aspergillus sp. strain HAB10R12's fractions (R1 and R2) on TNF-α induced insulin resistance in differentiated 3T3-L1 adipocytes / Nurul Rahimah Mohd Khair
description Insulin is responsible for regulation of glucose uptake and circulating free fatty acids (FF A). When there is insulin resistance, there will be an increased in circulating FF A concentrations and fat accumulation that impede insulin mediated glucose in skeletal muscle and elevated glucose production in liver. This will lead to the development of metabolism problem including Type 2 diabetes which can cause other serious problem such as cancer. Therefore, it is important to find a compound that able to reverse insulin resistance. There is growing evidence that bioactive substance produced by microbial endophytes have applicability in medicine, agriculture and industry . So, the aim of this research is to study the effect from fraction of endophytic Aspergillus sp. strain HAB10R12 (RI and R2) on normal 3T3-L1 adipocytes and insulin resistance 3T3-L1 cell induced by TNF-a. Results in MTT Assay test shown that RI and R2 treatments caused no cytotoxic effects to the normal 3T3-L1 cells and no IC50 value observed in the data. Besides, in glucose uptake test, when compared with the untreated insulin resistance cell, there was in increased in percentage of glucose uptake by insulin in the insulin resistance cell treated both RI and R2 treatments from the lowest concentration up to 0.01 µg/ml.
format Thesis
author Mohd Khair, Nurul Rahimah
author_facet Mohd Khair, Nurul Rahimah
author_sort Mohd Khair, Nurul Rahimah
title Effects of endophytic aspergillus sp. strain HAB10R12's fractions (R1 and R2) on TNF-α induced insulin resistance in differentiated 3T3-L1 adipocytes / Nurul Rahimah Mohd Khair
title_short Effects of endophytic aspergillus sp. strain HAB10R12's fractions (R1 and R2) on TNF-α induced insulin resistance in differentiated 3T3-L1 adipocytes / Nurul Rahimah Mohd Khair
title_full Effects of endophytic aspergillus sp. strain HAB10R12's fractions (R1 and R2) on TNF-α induced insulin resistance in differentiated 3T3-L1 adipocytes / Nurul Rahimah Mohd Khair
title_fullStr Effects of endophytic aspergillus sp. strain HAB10R12's fractions (R1 and R2) on TNF-α induced insulin resistance in differentiated 3T3-L1 adipocytes / Nurul Rahimah Mohd Khair
title_full_unstemmed Effects of endophytic aspergillus sp. strain HAB10R12's fractions (R1 and R2) on TNF-α induced insulin resistance in differentiated 3T3-L1 adipocytes / Nurul Rahimah Mohd Khair
title_sort effects of endophytic aspergillus sp. strain hab10r12's fractions (r1 and r2) on tnf-α induced insulin resistance in differentiated 3t3-l1 adipocytes / nurul rahimah mohd khair
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/110373/1/110373.PDF
https://ir.uitm.edu.my/id/eprint/110373/
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score 13.239859

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