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Estimation of amikacin pharmacokinetics in hospitalized geriatric patients / Siti Raufa Soriana Abdul Raub

The study was done to approximate the population pharmacokinetics of amikacin in hospitalized geriatric patients. The data of patients were collected from 2 hospitals and comprised of 64 TDM forms which 41 patients are male and 23 of them are female. The patients' demographics and pharmacokinet...

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Main Author: Abdul Raub, Siti Raufa Soriana
Format: Thesis
Language:English
Published: 2013
Subjects:
Pharmacopoeias
Online Access:https://ir.uitm.edu.my/id/eprint/110259/1/110259.PDF
https://ir.uitm.edu.my/id/eprint/110259/
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spelling my.uitm.ir.1102592025-02-16T08:29:08Z https://ir.uitm.edu.my/id/eprint/110259/ Estimation of amikacin pharmacokinetics in hospitalized geriatric patients / Siti Raufa Soriana Abdul Raub Abdul Raub, Siti Raufa Soriana Pharmacopoeias The study was done to approximate the population pharmacokinetics of amikacin in hospitalized geriatric patients. The data of patients were collected from 2 hospitals and comprised of 64 TDM forms which 41 patients are male and 23 of them are female. The patients' demographics and pharmacokinetics were analyzed to observe the pattern correlating to amikacin. The data was best described by a one-compartment model, The analysis has shown that there is a perfect relationship between rate of elimination, Ke and half-life, t1/2 with R2 value is 1. Furthermore, there is also a strong correlation between half-life and volume of distribution per clearance (Vd/CL) as R2 is 0.777. The mean of Ke, t1/2, and V d in this study, (0.075 ± 0.04 hr-1 ), (11.53 ± 4.97 hr) and (0.51 ± 0.28 1./kg) respectively. The COV value (more than 10%) has shown a high inter­ patient variability in terms of pharmacokinetics. The pattern of pharmacokinetics among geriatrics also has been identified; however, the actual practice shouJd able to refer to an exact patient fur accuracy. In short, the population pharmacokinetics of hospitalized geriatrics has less inter-patient variability either from hospitals, or gender or weight. However, it is necessary to monitor the patients individually in order to avoid toxicities and achieve therapeutic goal 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/110259/1/110259.PDF Estimation of amikacin pharmacokinetics in hospitalized geriatric patients / Siti Raufa Soriana Abdul Raub. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmacopoeias
spellingShingle Pharmacopoeias
Abdul Raub, Siti Raufa Soriana
Estimation of amikacin pharmacokinetics in hospitalized geriatric patients / Siti Raufa Soriana Abdul Raub
description The study was done to approximate the population pharmacokinetics of amikacin in hospitalized geriatric patients. The data of patients were collected from 2 hospitals and comprised of 64 TDM forms which 41 patients are male and 23 of them are female. The patients' demographics and pharmacokinetics were analyzed to observe the pattern correlating to amikacin. The data was best described by a one-compartment model, The analysis has shown that there is a perfect relationship between rate of elimination, Ke and half-life, t1/2 with R2 value is 1. Furthermore, there is also a strong correlation between half-life and volume of distribution per clearance (Vd/CL) as R2 is 0.777. The mean of Ke, t1/2, and V d in this study, (0.075 ± 0.04 hr-1 ), (11.53 ± 4.97 hr) and (0.51 ± 0.28 1./kg) respectively. The COV value (more than 10%) has shown a high inter­ patient variability in terms of pharmacokinetics. The pattern of pharmacokinetics among geriatrics also has been identified; however, the actual practice shouJd able to refer to an exact patient fur accuracy. In short, the population pharmacokinetics of hospitalized geriatrics has less inter-patient variability either from hospitals, or gender or weight. However, it is necessary to monitor the patients individually in order to avoid toxicities and achieve therapeutic goal
format Thesis
author Abdul Raub, Siti Raufa Soriana
author_facet Abdul Raub, Siti Raufa Soriana
author_sort Abdul Raub, Siti Raufa Soriana
title Estimation of amikacin pharmacokinetics in hospitalized geriatric patients / Siti Raufa Soriana Abdul Raub
title_short Estimation of amikacin pharmacokinetics in hospitalized geriatric patients / Siti Raufa Soriana Abdul Raub
title_full Estimation of amikacin pharmacokinetics in hospitalized geriatric patients / Siti Raufa Soriana Abdul Raub
title_fullStr Estimation of amikacin pharmacokinetics in hospitalized geriatric patients / Siti Raufa Soriana Abdul Raub
title_full_unstemmed Estimation of amikacin pharmacokinetics in hospitalized geriatric patients / Siti Raufa Soriana Abdul Raub
title_sort estimation of amikacin pharmacokinetics in hospitalized geriatric patients / siti raufa soriana abdul raub
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/110259/1/110259.PDF
https://ir.uitm.edu.my/id/eprint/110259/
_version_ 1825165169389469696
score 13.239859

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