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Pectin for transdermal drug delivery system : a histological assessment / Fazrul Haiqal Ab Rahman

The effect of pectin as transdennal drug delivery system matrix on rat skin histology was investigated. Oleic acid (OA) was employed as a penetration enhancer. Four types of films and gels were prepared by dissolving the pectin powder with or without oleic acid in deionised water under continuous st...

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Main Author: Ab Rahman, Fazrul Haiqal
Format: Thesis
Language:English
Published: 2013
Subjects:
Drugs and their actions
Online Access:https://ir.uitm.edu.my/id/eprint/109601/1/109601.PDF
https://ir.uitm.edu.my/id/eprint/109601/
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spelling my.uitm.ir.1096012025-01-31T23:51:46Z https://ir.uitm.edu.my/id/eprint/109601/ Pectin for transdermal drug delivery system : a histological assessment / Fazrul Haiqal Ab Rahman Ab Rahman, Fazrul Haiqal Drugs and their actions The effect of pectin as transdennal drug delivery system matrix on rat skin histology was investigated. Oleic acid (OA) was employed as a penetration enhancer. Four types of films and gels were prepared by dissolving the pectin powder with or without oleic acid in deionised water under continuous stirring at 25 ± 1°C for 15 h. Rat skin applied with the films and gels were subsequently subjected to the staining method by Harris Haematoxylin-Eosin (H&E) and Oil Red O (ORO) Stain Kit for histological examination. The application of pectin on rat skin did not induce skin damage as shown by the cross-sectional histology of skin stained by H&E and ORO. No significant amount of oleic acid permeated through the skin from pectin film or gel when compared to the skin applied with OA-free film or gel. The pectin molecules could act as a binding agent for epidermis and dermis, hence creating and impermeable skin barrier for permeation of oleic acid. Further study is needed in order to explore the use of pectin as a matrix polymer for transdermal drug delivery system. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109601/1/109601.PDF Pectin for transdermal drug delivery system : a histological assessment / Fazrul Haiqal Ab Rahman. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Drugs and their actions
spellingShingle Drugs and their actions
Ab Rahman, Fazrul Haiqal
Pectin for transdermal drug delivery system : a histological assessment / Fazrul Haiqal Ab Rahman
description The effect of pectin as transdennal drug delivery system matrix on rat skin histology was investigated. Oleic acid (OA) was employed as a penetration enhancer. Four types of films and gels were prepared by dissolving the pectin powder with or without oleic acid in deionised water under continuous stirring at 25 ± 1°C for 15 h. Rat skin applied with the films and gels were subsequently subjected to the staining method by Harris Haematoxylin-Eosin (H&E) and Oil Red O (ORO) Stain Kit for histological examination. The application of pectin on rat skin did not induce skin damage as shown by the cross-sectional histology of skin stained by H&E and ORO. No significant amount of oleic acid permeated through the skin from pectin film or gel when compared to the skin applied with OA-free film or gel. The pectin molecules could act as a binding agent for epidermis and dermis, hence creating and impermeable skin barrier for permeation of oleic acid. Further study is needed in order to explore the use of pectin as a matrix polymer for transdermal drug delivery system.
format Thesis
author Ab Rahman, Fazrul Haiqal
author_facet Ab Rahman, Fazrul Haiqal
author_sort Ab Rahman, Fazrul Haiqal
title Pectin for transdermal drug delivery system : a histological assessment / Fazrul Haiqal Ab Rahman
title_short Pectin for transdermal drug delivery system : a histological assessment / Fazrul Haiqal Ab Rahman
title_full Pectin for transdermal drug delivery system : a histological assessment / Fazrul Haiqal Ab Rahman
title_fullStr Pectin for transdermal drug delivery system : a histological assessment / Fazrul Haiqal Ab Rahman
title_full_unstemmed Pectin for transdermal drug delivery system : a histological assessment / Fazrul Haiqal Ab Rahman
title_sort pectin for transdermal drug delivery system : a histological assessment / fazrul haiqal ab rahman
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109601/1/109601.PDF
https://ir.uitm.edu.my/id/eprint/109601/
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score 13.235796

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