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Paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / Mustaqim Abd Rashid

In this work, a nanoformulation of pacliatxel with biodegradable thermo-responsive N­ vinyl caprolactam (NYC) is developed for delivery to cancer cells. The thermo­ responsive graft co-polymeric nanoparticles (PNVC-MAAc) were prepared by dispersion polymerization method, which showed a lower critica...

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Bibliographic Details
Main Author: Abd Rashid, Mustaqim
Format: Thesis
Language:English
Published: 2013
Subjects:
Cancer
Drugs and their actions
Online Access:https://ir.uitm.edu.my/id/eprint/109554/1/109554.PDF
https://ir.uitm.edu.my/id/eprint/109554/
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id my.uitm.ir.109554
record_format eprints
spelling my.uitm.ir.1095542025-01-31T23:53:15Z https://ir.uitm.edu.my/id/eprint/109554/ Paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / Mustaqim Abd Rashid Abd Rashid, Mustaqim Cancer Drugs and their actions In this work, a nanoformulation of pacliatxel with biodegradable thermo-responsive N­ vinyl caprolactam (NYC) is developed for delivery to cancer cells. The thermo­ responsive graft co-polymeric nanoparticles (PNVC-MAAc) were prepared by dispersion polymerization method, which showed a lower critical solution temperature (LCST). The paclitaxel drug was incorporated into the carrier using cross-linking reaction. After several characterizations, it was found that the nanoformulation developed met the characteristics fit for cancer drug delivery such as appeared in nanometer in size, better morphology and improve the surface charge of the NPs. These results indicated that PTX-PNVC-MAAc NPs could be a promising candidate for cancer drug delivery. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109554/1/109554.PDF Paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / Mustaqim Abd Rashid. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Cancer
Drugs and their actions
spellingShingle Cancer
Drugs and their actions
Abd Rashid, Mustaqim
Paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / Mustaqim Abd Rashid
description In this work, a nanoformulation of pacliatxel with biodegradable thermo-responsive N­ vinyl caprolactam (NYC) is developed for delivery to cancer cells. The thermo­ responsive graft co-polymeric nanoparticles (PNVC-MAAc) were prepared by dispersion polymerization method, which showed a lower critical solution temperature (LCST). The paclitaxel drug was incorporated into the carrier using cross-linking reaction. After several characterizations, it was found that the nanoformulation developed met the characteristics fit for cancer drug delivery such as appeared in nanometer in size, better morphology and improve the surface charge of the NPs. These results indicated that PTX-PNVC-MAAc NPs could be a promising candidate for cancer drug delivery.
format Thesis
author Abd Rashid, Mustaqim
author_facet Abd Rashid, Mustaqim
author_sort Abd Rashid, Mustaqim
title Paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / Mustaqim Abd Rashid
title_short Paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / Mustaqim Abd Rashid
title_full Paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / Mustaqim Abd Rashid
title_fullStr Paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / Mustaqim Abd Rashid
title_full_unstemmed Paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / Mustaqim Abd Rashid
title_sort paclitaxel loaded and surface coated n-vinyl caprolactam nanoparticles for breast cancer drug delivery / mustaqim abd rashid
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109554/1/109554.PDF
https://ir.uitm.edu.my/id/eprint/109554/
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score 13.235796

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