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Apoptotic activity of manuka honey towards MCF-7 breast cancer cell lines / Siti Aisyah Su Azmi

Breast cancer is a type of cancers that most commonly occurred in women. Despite all the therapies available nowadays, alternative therapeutic measure such as natural products can be developed to fight against this deadly disease. Anti-cancer therapy by using honey which has antioxidant properties c...

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Main Author: Su Azmi, Siti Aisyah
Format: Thesis
Language:English
Published: 2013
Subjects:
Cancer
Online Access:https://ir.uitm.edu.my/id/eprint/109526/1/109526.PDF
https://ir.uitm.edu.my/id/eprint/109526/
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spelling my.uitm.ir.1095262025-01-31T23:53:47Z https://ir.uitm.edu.my/id/eprint/109526/ Apoptotic activity of manuka honey towards MCF-7 breast cancer cell lines / Siti Aisyah Su Azmi Su Azmi, Siti Aisyah Cancer Breast cancer is a type of cancers that most commonly occurred in women. Despite all the therapies available nowadays, alternative therapeutic measure such as natural products can be developed to fight against this deadly disease. Anti-cancer therapy by using honey which has antioxidant properties can be used to induce the apoptotic activity and causing morphological changes to the cell. In this experiment, apoptotic activity of MCF-7 breast cancer cell lines challenged with Manuka honey was studied. The content of phenolic and flavonoid in the honey which have antioxidant activity was quantified using total phenolic content and total flavonoid content test. The results showed that Manuka honey has 64.67g of GAE/Land 33.13 g of CEIL. Apoptotic features of treated MCF- 7 cells were examined under the transmission electron microscope. The image showed that treated cell exhibited signs of apoptosis including chromatin condensation, nuclear shrinkage, membrane blebbing, cytoplasmic shrinkage and cytoplasmic vacuoles. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109526/1/109526.PDF Apoptotic activity of manuka honey towards MCF-7 breast cancer cell lines / Siti Aisyah Su Azmi. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Cancer
spellingShingle Cancer
Su Azmi, Siti Aisyah
Apoptotic activity of manuka honey towards MCF-7 breast cancer cell lines / Siti Aisyah Su Azmi
description Breast cancer is a type of cancers that most commonly occurred in women. Despite all the therapies available nowadays, alternative therapeutic measure such as natural products can be developed to fight against this deadly disease. Anti-cancer therapy by using honey which has antioxidant properties can be used to induce the apoptotic activity and causing morphological changes to the cell. In this experiment, apoptotic activity of MCF-7 breast cancer cell lines challenged with Manuka honey was studied. The content of phenolic and flavonoid in the honey which have antioxidant activity was quantified using total phenolic content and total flavonoid content test. The results showed that Manuka honey has 64.67g of GAE/Land 33.13 g of CEIL. Apoptotic features of treated MCF- 7 cells were examined under the transmission electron microscope. The image showed that treated cell exhibited signs of apoptosis including chromatin condensation, nuclear shrinkage, membrane blebbing, cytoplasmic shrinkage and cytoplasmic vacuoles.
format Thesis
author Su Azmi, Siti Aisyah
author_facet Su Azmi, Siti Aisyah
author_sort Su Azmi, Siti Aisyah
title Apoptotic activity of manuka honey towards MCF-7 breast cancer cell lines / Siti Aisyah Su Azmi
title_short Apoptotic activity of manuka honey towards MCF-7 breast cancer cell lines / Siti Aisyah Su Azmi
title_full Apoptotic activity of manuka honey towards MCF-7 breast cancer cell lines / Siti Aisyah Su Azmi
title_fullStr Apoptotic activity of manuka honey towards MCF-7 breast cancer cell lines / Siti Aisyah Su Azmi
title_full_unstemmed Apoptotic activity of manuka honey towards MCF-7 breast cancer cell lines / Siti Aisyah Su Azmi
title_sort apoptotic activity of manuka honey towards mcf-7 breast cancer cell lines / siti aisyah su azmi
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109526/1/109526.PDF
https://ir.uitm.edu.my/id/eprint/109526/
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score 13.235796

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